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CR2 encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Additionally we are shipping Complement Component (3d/Epstein Barr Virus) Receptor 2 Antibodies (452) and Complement Component (3d/Epstein Barr Virus) Receptor 2 Kits (13) and many more products for this protein.
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Human CR2 Protein expressed in Human Cells - ABIN2003429
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Show all 5 references for ABIN2003429
In mature B cells, CD21 transcription proceeds from a focused transcriptional start site regulated by a non-consensus TATA box, an initiator element and a downstream promoter element.
Reduced expression of CD21 on CLL B-cells appears functionally relevant and was associated with poor clinical outcomes.
These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to systemic lupus erythematosus.
repression of the CR2/CD21 promoter can occur through one of the E-box motifs via recruitment of RP58 (show ZNF238 Proteins).
found that the protective CR2 genotype is correlated with lower levels CR2 mRNA as well as differences in the ratio of the long and short CR2 isoforms
The paradoxical enhancement of immune responses by C3d (show C3 Proteins) in the absence of CD21 is due to internalization and processing of C3d (show C3 Proteins) into peptides that activate autoreactive CD4 (show CD4 Proteins)(+) T-helper cells.
THE COMBINATION OF EXPRESSION OF MARKERS CR1 AND CR2 (CD35/CD21) IN DIAGNOSTIC OF B-CELL LYMPHOPROLIFERATIVE DISEASES
Higher C3d (show C3 Proteins)/C3 ratios were found for current smoker, higher age, age-related macular degeneration phenotype, and the two SNPs in the C3 gene, rs6795735 and rs2230199.
Authors show that expression of the Epstein-Barr virus B-cell attachment receptor, CD21, in B cells that lack this receptor results in significant changes in gene expression, both before and rapidly following EBV-CD21 interaction.
Our findings implicate CR2 as a susceptibility gene for nasopharyngeal carcinoma and suggest that enhanced CR2 expression may be involved in the oncogenesis and development of nasopharyngeal carcinoma.
Cattle express two major variants of the Cr2 gene representing homologues of murine CR1 and CR2, each of which is expressed in both a long and a short form.
These results demonstrate that local expression of Cr2 in the central nervous system is part of the axotomy reaction and is suggested to modulate subsequent complement mediated effects.
This study demonistrated that receptors for complement C3 (show C3 Proteins) fragments (CR2/CR1) may represent a promising future approach for therapeutic immunomodulation after traumatic brain injury.
Data suggest that the Cr2KO mouse thus provides a new model system for the analysis of Cr1 and Cr2 functions in the immune response of the mouse.
Murine B cells predominantly express the Cr2 product from the Cr2 gene, whereas follicular dendritic cells (FDCs) almost exclusively express the Cr1 isoform generated from the Cr2 gene.
immune system uses three different CR1 (show TDGF1 Proteins)/2-mediated effector functions to generate optimal antibody responses
Absence of CD21/35 protects mice from chronic wasting disease.
We conclude that Cr2 regulates hippocampal neurogenesis
There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry (show CR1L Proteins) or CR2-factor H (show CFH Proteins).
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.
functionally significant phenotype for the NZM2410 Cr2 allele and strongly support its role as a lupus susceptibility gene
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, complement C3d receptor
, complement receptor type 2
, epstein-Barr virus receptor
, complement component receptor 2
, complement receptor 1 long isoform
, complement receptor 2
, complement receptor type 1
, expressed in B lymphocytes