Complement Component 5a Receptor 1 Proteins (C5AR1)

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Additionally we are shipping C5AR1 Antibodies (274) and C5AR1 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C5AR1 12273  
C5AR1 728 P21730
Rat C5AR1 C5AR1 113959 P97520
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Top C5AR1 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$491.43
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$205.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

C5AR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

Top referenced C5AR1 Proteins

  1. Human C5AR1 Protein expressed in Wheat germ - ABIN1347567 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

More Proteins for Complement Component 5a Receptor 1 (C5AR1) Interaction Partners

Mouse (Murine) Complement Component 5a Receptor 1 (C5AR1) interaction partners

  1. C5aR1 facilities the pathogenesis of chronic kidney infection by enhancement of bacterial colonization of tubular epithelium, promotion of local inflammatory responses, and impairment of phagocytic function of monocytes/macrophages.

  2. Data indicate that complement component 5a receptor 1 protein (C5aR1) signaling in osteoblasts plays a detrimental role in bone regeneration after fracture.

  3. The role of C5aR1 and C5aR2 in response to renal ischemia-reperfusion injury is reported. The results also demonstrated that C5aR2 is a functional receptor, rather than a decoy receptor, and may provide a new target for intervention.

  4. these data reveal a differential role for C5aR during ethanol-induced liver inflammation and injury

  5. These findings demonstrate a complex regulation pattern of C5aR1 in the airways, lung tissue and mediastinal lymph nodes of mice, suggesting that the C5a/C5aR1 axis controls airway constriction and inflammation through activation of myeloid cells in all three compartments in an experimental model of allergic asthma.

  6. C5aR1-KO mice exhibited less renal injury, as evidenced by reduced albuminuria. In contrast, cardiac injury was accelerated with increased cardiac fibrosis and heart weight in C5aR1-deficient mice after ANG II (show AGT Proteins) infusion. No effect was found on blood pressure. the C5a:C5aR1 axis drives end-organ damage in the kidney but protects from the development of cardiac fibrosis and hypertrophy in experimental hypertension.

  7. This study demonstrated that C5aR1 contributes to the acute inflammatory response elicited by infiltrating immune cells following pilocarpine status epilepticus.

  8. Regulation of complement 5a receptor (C5aR)-induced neutrophil chemotaxis via IgG1 immune complexes (ICs (show DNAI1 Proteins)) depends on galectin-3 (show LGALS3 Proteins).

  9. The C5a/C5aR pathway is essential for up-regulating SphK1 (show SPHK1 Proteins) expression through p38 MAPK (show MAPK14 Proteins) activation in acute liver failure.in mice.

  10. C5a bidirectionally amplifies TLR4 (show TLR4 Proteins)-mediated NLRP3 (show NLRP3 Proteins) inflammasome activation in monocytes while suppressing this pathway in macrophages. However, as C5aR1 deficiency attenuates the IL-1beta (show IL1B Proteins) response to LPS (show TLR4 Proteins) challenge in vivo, results suggest overall that C5a augments physiologic inflammasome responses.

Human Complement Component 5a Receptor 1 (C5AR1) interaction partners

  1. TLR4 (show TLR4 Proteins) and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Proteins), PI3Kbeta, SGK1 (show SGK1 Proteins), and FOXO (show FOXO3 Proteins) transcription factors.

  2. Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (show IL8 Proteins) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (show IL8 Proteins) expression via PI3K (show PIK3CA Proteins) and MEK (show MAP2K1 Proteins). Study demonstrated expression of IL-8 (show IL8 Proteins) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.

  3. Reducing RPS19 (show RPS19 Proteins) in tumor cells or blocking the C5a receptor 1-RPS19 (show RPS19 Proteins) interaction decreases RPS19 (show RPS19 Proteins)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer

  4. C5aR expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.

  5. this study shows that downregulation of CD88 after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults

  6. Relation of C5aR expression to tumor development and poor prognosis of the breast cancer patients

  7. The objective of the present study was to validate a receptor occupancy (RO) assay for a human anti-C5aR monoclonal antibody drug candidate, NNC0215-0384 (NN0384)

  8. These data thus suggest that C5aR1 acts as an enhancer of CCR5-mediated HIV entry into macrophages, the targeting of which may prove useful to reduce HIV infection by R5 strains.

  9. C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.

  10. that C5aR stimulates cell invasion and migration via ERK1/2-mediated epithelial-mesenchymal transition in hepatocellular carcinoma cells

Cow (Bovine) Complement Component 5a Receptor 1 (C5AR1) interaction partners

  1. Studies provide information regarding distinct structural and functional features that may contribute to the unique pharmacological properties of bovine C5aR.

C5AR1 Protein Profile

Protein Summary

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Gene names and symbols associated with C5AR1

  • complement component 5a receptor 1 (C5AR1)
  • complement component 5a receptor 1 (c5ar1)
  • C5a anaphylatoxin chemotactic receptor-like (LOC100352978)
  • complement component 5a receptor 1 (C5ar1)
  • C5A protein
  • C5AR protein
  • C5AR1 protein
  • C5r1 protein
  • CD88 protein
  • D7Msu1 protein
  • GPR77 protein

Protein level used designations for C5AR1

complement component 5a receptor 1 , C5a anaphylatoxin receptor , G protein-coupled receptor 77 , C5a anaphylatoxin chemotactic receptor 1 , C5a ligand , C5a-R , complement component 5, receptor 1 , complement component 5 receptor 1 , C5aR , complement C5a receptor , anaphylatoxin C5a receptor , complement component 5 receptor 1 (C5a ligand) , C5a anaphylatoxin chemotactic receptor

GENE ID SPECIES
397287 Sus scrofa
430484 Gallus gallus
100379958 Xenopus (Silurana) tropicalis
100589337 Nomascus leucogenys
100352978 Oryctolagus cuniculus
12273 Mus musculus
728 Homo sapiens
113959 Rattus norvegicus
100135489 Cavia porcellus
442974 Canis lupus familiaris
718056 Macaca mulatta
468931 Pan troglodytes
100048955 Sus scrofa
493645 Bos taurus
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