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anti-Complement Factor H-Related 4 (CFHR4) Antibodies

CFHR4 is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. Additionally we are shipping Complement Factor H-Related 4 Kits (9) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CFHR4 10877 Q92496
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Top anti-Complement Factor H-Related 4 Antibodies at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Sheep Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$947.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details

CFHR4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human
,

More Antibodies against Complement Factor H-Related 4 Interaction Partners

Human Complement Factor H-Related 4 (CFHR4) interaction partners

  1. Next-generation sequencing of the CFH (show CFH Antibodies) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (show CFH Antibodies)-related genes in the retina or RPE (show RPE Antibodies)/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR4]

  2. Studies indicate that complement factor H (show CFH Antibodies)-related proteins (FHR1 (show CFHR1 Antibodies)-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  3. Factor H (show CFH Antibodies)-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein

  4. Systemic lupus erythematosus were detected in European Americans and African Americans, which could be attributed to an intronic complement regulator factor H (CFH (show CFH Antibodies)) single nucleotide polymorphism (SNP) and an intergenic SNP between CFHR1 (show CFHR1 Antibodies) and CFHR4.

  5. These data reveal the molecular basis of the specific interaction of CFHR4 with native CRP (show CRP Antibodies) and suggest a role for CFHR4 in enhancing opsonization via CRP (show CRP Antibodies) binding.

  6. Association of factor H (show CFH Antibodies) autoantibodies with deletions of CFHR1 (show CFHR1 Antibodies), CFHR3 (show CFHR3 Antibodies), CFHR4, and with mutations in CFH (show CFH Antibodies), CFI (show CFI Antibodies), CD46 (show CD46 Antibodies), and C3 in patients with atypical hemolytic uremic syndrome.

  7. FHR-4A is a new Factor H (show CFH Antibodies)-related protein with a unique domain composition, that is an internal duplication of four CCP (show CRYGD Antibodies) domains FHR-4A provides the first evidence for alternative splicing among Factor H (show CFH Antibodies)-related genes.

  8. These data identify CFHR4 as a novel ligand for native CRP (show CRP Antibodies), and suggest a role for CFHR4 in opsonization of necrotic cells.

Complement Factor H-Related 4 (CFHR4) Antigen Profile

Protein Summary

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene.

Gene names and symbols associated with CFHR4

  • complement factor H-related 4 (CFHR4) antibody
  • CFHL4 antibody
  • FHR-4 antibody
  • FHR4 antibody

Protein level used designations for CFHR4

complement factor H-related protein 4

GENE ID SPECIES
10877 Homo sapiens
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