You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Complexin 1 (CPLX1) Antibodies

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. Additionally we are shipping Complexin 1 Proteins (15) and Complexin 1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CPLX1 10815 O14810
CPLX1 12889 P63040
CPLX1 64832 P63041
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Complexin 1 Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of CPLX1 Antibody (Center) (ABIN653361) in mouse brain tissue lysates (35 µg/lane). CPLX1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with CPLX1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed,  paraffin-embedded human brain tissue reacted with Complexin-1 Antibody (Center) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of Complexin-1 Antibody (Center) in Mouse brain tissue lysates (35ug/lane). CPLX1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit FITC IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

CPLX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, ,

, , , , , , , , , , , , , ,
Mouse (Murine) , ,
, ,

, , , , , , , , , , ,
Rat (Rattus) , ,
,

, , , , , , , , , , ,

Top referenced anti-Complexin 1 Antibodies

  1. Human Polyclonal Complexin 1 Primary Antibody for EIA, IHC (p) - ABIN951657 : Salimi, Glantz, Hamer, German, Gilmore, Jarskog: Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex. in Synapse (New York, N.Y.) 2008 (PubMed)
    Show all 4 references for ABIN951657

  2. Human Polyclonal Complexin 1 Primary Antibody for IHC (p), WB - ABIN653361 : Giraudo, Eng, Melia, Rothman: A clamping mechanism involved in SNARE-dependent exocytosis. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 2 references for ABIN653361

More Antibodies against Complexin 1 Interaction Partners

Human Complexin 1 (CPLX1) interaction partners

  1. Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1.

  2. Studies indicate the role of the small regulatory factor complexin in Ca(2 (show CA2 Antibodies)+)-dependent vesicle fusion and exocytosis.

  3. Together with synaptotagmin 1 (show SYT1 Antibodies), complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2 (show CA2 Antibodies)+) concentrations.

  4. The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and inhibiting its assembly, to clamp fusion.

  5. The 'central helix' of complexin is anchored to one SNARE (show NAPA Antibodies) complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE (show VTI1B Antibodies) binding site to inhibit fusion.

  6. description of what may represent a basic principle of the coupling mechanism in SNARE (show NAPA Antibodies) dependent exocytosis: a reversible clamping protein, complexin, that can freeze the SNAREpin, an assembled fusion-competent intermediate en route to fusion

Mouse (Murine) Complexin 1 (CPLX1) interaction partners

  1. The response of CPLX1 and Foxp1 (show FOXP1 Antibodies) levels to SNCA (show SNCA Antibodies) deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein (show SNCA Antibodies).

  2. In the absence of Cplx1, synaptic vesicles remain unstable and prone to premature fusion.

  3. Cplx 1 and 2 play a role in facilitating vesicle priming, and also lead to the new hypothesis that Cplxs may synchronize vesicle release by promoting coupling between secretory vesicles and calcium channels.

  4. Complexin-1 carboxyl-terminal domain binds lipids through a novel protein motif by targeting complexin-1 to synaptic vesicles.

  5. the ataxia (show USP14 Antibodies) in Cplx1(-/-) mice is likely to be due to pathological changes in both cerebellum and thalamus

  6. This study demonistrated that relatively large C-terminal complexin-1 sequence acts in priming and clamping synaptic exocytosis and demonstrate that the clamping function

  7. The study uncovers an interaction between the complexin-1 N terminus and the SNARE (show VTI1B Antibodies) complex C terminus, and shows that disrupting this interaction abolishes the facilitatory function of complexins in mouse neurons.

  8. CPX I plays a critical role in beta-cells in the control of the stimulated-exocytosis of insulin (show INS Antibodies).

  9. Here we propose that complexin binding activates SNARE (show VTI1B Antibodies) complexes into a metastable state and that Ca(2 (show CA2 Antibodies)+) binding to synaptotagmin 1 (show SYT1 Antibodies) triggers fast exocytosis by displacing complexin from metastable SNARE (show VTI1B Antibodies) complexes.

  10. Its co-localization and interaction with complexin I suggest that dynamin 2 (show DNM2 Antibodies) may play a role during acrosome formation and/or acrosomal exocytosis.

Complexin 1 (CPLX1) Antigen Profile

Protein Summary

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.

Gene names and symbols associated with anti-Complexin 1 (CPLX1) Antibodies

  • complexin 1 (cplx1) antibody
  • complexin 1 (CPLX1) antibody
  • complexin 1 (Cplx1) antibody
  • complexin 2 (CPLX2) antibody
  • 921-S antibody
  • CPLX1 antibody
  • CPX-I antibody
  • CPX1 antibody
  • MGC84299 antibody

Protein level used designations for anti-Complexin 1 (CPLX1) Antibodies

complexin 1 , complexin-1 , CPX I , complexin I , synaphin 2 , synaphin-2

GENE ID SPECIES
447770 Xenopus laevis
479134 Canis lupus familiaris
703519 Macaca mulatta
100124828 Xenopus (Silurana) tropicalis
10815 Homo sapiens
768228 Bos taurus
12889 Mus musculus
64832 Rattus norvegicus
427286 Gallus gallus
Selected quality suppliers for anti-Complexin 1 (CPLX1) Antibodies
Did you look for something else?