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The protein encoded by CRX is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. Additionally we are shipping Cone-Rod Homeobox Antibodies (45) and many more products for this protein.
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Human CRX Protein expressed in Wheat germ - ABIN1350411
Santagata, Maire, Idbaih, Geffers, Correll, Holton, Quackenbush, Ligon: CRX is a diagnostic marker of retinal and pineal lineage tumors. in PLoS ONE 2009
CRX can influence the development and opsin (show RHO Proteins) expression of photoreceptor outer segments in zebrafish.
The CRX protein can recognize the BAT 1 (show DDX39B Proteins) regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences.
No mutation in crx were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to crx.
data demonstrate the successful application of ZFN technology to generate CRX-GFP labeled hESC lines, which can be used to study and isolate photoreceptor precursors during hESC differentiation.
Loss of OTX2 (show OTX2 Proteins) expression resulted in decreased expression of C-MYC (show MYC Proteins) and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 (show OTX2 Proteins) expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation
Mutations involving the CRX gene may demonstrate an autosomal dominant inheritance pattern for leber congenital amaurosis.
Con (show DISP1 Proteins) rod homeobox protein mRNA is a novel marker for retinoblastoma at extraocular sites.
Two de novo mutations in CRX were found in Chinese patients with Leber congenital amaurosis. The CRX mutation might create a dominantly inherited trait.
Mutations in CRX demonstrate significant phenotypic heterogeneity both between and within pedigrees. A novel, adult-onset, macular dystrophy phenotype is characterized, further extending our knowledge of the etiology of dominant macular dystrophies.
CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors
Data have identified a novel retinal SAM (show TTN Proteins) domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.
the potential utility of CRX as a marker of pineal lineage in routine diagnostic neuropathology.
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
OTR1 (show OXTR Proteins), OTX2 (show OTX2 Proteins) and CRX act as positive modulators of the BEST1 (show BEST1 Proteins) promoter in the retinal pigment epithelium.
proteins involved in phototransduction were not detected in the Crx(-/-) mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes.
The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction.
CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.
Rax (show RAX Proteins) and Crx cooperatively transactivate Rhodopsin (show RHO Proteins) and cone opsin (show RHO Proteins) promoters and an optimum Rax (show RAX Proteins) expression level to transactivate photoreceptor gene expression exists.
E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.
The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat (show AANAT Proteins) expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis
We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2 (show KCNV2 Proteins).
In Crx-knockout mice vasopressin (show AVP Proteins) mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.
Our results show that NRL (show NRL Proteins) and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis (show CISH Proteins)-regulatory module
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
, homeobox protein otx5
, orthodenticle homolog 5
, cone-rod homeobox protein
, orthodenticle homeobox 3
, crx gene for cone-rod homeobox protein
, photoreceptor-specific cone-rod homeobox protein
, cone-rod homeobox containing