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Connector Enhancer of Kinase Suppressor of Ras 1 Proteins (CNKSR1)

CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. Additionally we are shipping Connector Enhancer of Kinase Suppressor of Ras 1 Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNKSR1 10256 Q969H4
Mouse CNKSR1 CNKSR1 194231  
Rat CNKSR1 CNKSR1 298545  
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Top Connector Enhancer of Kinase Suppressor of Ras 1 Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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CNKSR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Interaction Partners

Human Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) interaction partners

  1. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.

  2. CNK1 mediates ephrinB1 (show EFNB1 Proteins) signaling that promotes cell migration through RhoA (show RHOA Proteins) and JNK (show MAPK8 Proteins) activity.

  3. Studies indicate that CNK1-driven proliferation relies on Akt (show AKT1 Proteins)-dependent phosphorylation and inactivation of FoxO (show FOXO3 Proteins) proteins.

  4. These findings identify CNK1 as a new positive regulator of insulin (show INS Proteins) signaling.

  5. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.

  6. CNK1 promotes oncogenic signalling through Akt (show AKT1 Proteins) in breast cancer cell lines and tumours.

  7. hCNK1 associates with Rhophilin (show RHPN1 Proteins) and RalGDS (show RALGDS Proteins), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (show HOMER1 Proteins) to mediate cross talk between the two pathways

  8. Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras.

  9. CNK1 couples a subset of Rho exchange factors to activation of the JNK (show MAPK8 Proteins) MAP kinase (show MAPK1 Proteins) pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho.

  10. CNK1 allows cross-talk between Src (show SRC Proteins) and Raf-1 (show RAF1 Proteins) and is essential for the full activation of Raf-1 (show RAF1 Proteins)

Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Protein Profile

Protein Summary

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.

Gene names and symbols associated with CNKSR1

  • connector enhancer of kinase suppressor of Ras 1 (cnksr1)
  • connector enhancer of kinase suppressor of Ras 1 (CNKSR1)
  • connector enhancer of kinase suppressor of Ras 1 (Cnksr1)
  • connector enhancer of kinase suppressor of ras 1-like (LOC617552)
  • BC037758 protein
  • CNK protein
  • CNK1 protein
  • CNKSR1 protein
  • KSR protein
  • zgc:77200 protein

Protein level used designations for CNKSR1

connector enhancer of kinase suppressor of ras 1 , connector enhancer of kinase suppressor of Ras 1 , connector enhancer of kinase suppressor of ras 1-like , CNK homolog protein 1 , connector enhancer of KSR 1 , hCNK1

GENE ID SPECIES
402957 Danio rerio
469241 Pan troglodytes
100015613 Monodelphis domestica
100144653 Xenopus (Silurana) tropicalis
100158310 Xenopus laevis
100462050 Pongo abelii
100476443 Ailuropoda melanoleuca
10256 Homo sapiens
487359 Canis lupus familiaris
100624309 Sus scrofa
194231 Mus musculus
298545 Rattus norvegicus
617552 Bos taurus
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