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CNTNAP2 encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. Additionally we are shipping CNTNAP2 Proteins (6) and CNTNAP2 Kits (4) and many more products for this protein.
Showing 10 out of 57 products:
Human Polyclonal CNTNAP2 Primary Antibody for EIA, WB - ABIN453579
Denisenko-Nehrbass, Oguievetskaia, Goutebroze, Galvez, Yamakawa, Ohara, Carnaud, Girault: Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres. in The European journal of neuroscience 2003
Show all 2 references for ABIN453579
Mouse (Murine) Polyclonal CNTNAP2 Primary Antibody for ELISA - ABIN2001277
Verkerk, Mathews, Joosse, Eussen, Heutink, Oostra: CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. in Genomics 2003
Human Polyclonal CNTNAP2 Primary Antibody for ICC, IF - ABIN4288206
Krumbiegel, Pasutto, Schlötzer-Schrehardt, Uebe, Zenkel, Mardin, Weisschuh, Paoli, Gramer, Becker, Ekici, Weber, Nürnberg, Kruse, Reis: Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome. in European journal of human genetics : EJHG 2011
Human Monoclonal CNTNAP2 Primary Antibody for IHC, IHC (fro) - ABIN4288205
Horresh, Bar, Kissil, Peles: Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Human Polyclonal CNTNAP2 Primary Antibody for - ABIN2017587
Chen, Koopmans, Gordon, Paliukhovich, Klaassen, van der Schors, Peles, Verhage, Smit, Li: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. in Biochimica et biophysica acta 2015
rs7794745 in the CNTNAP2 gene was associated with autistic spectrum disorder in Brazilian patients.
we could not detect any significant association with the CNTNAP2 gene and high functioning autism
CNTNAP2 is transcriptionally regulated by FOXP2 (show FOXP2 Antibodies).
Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 (show CNTN1 Antibodies) but, under the same conditions, it does not interact with any of the other members of the contactin family.
Results indicate that the CNTNAP2 gene may confer vulnerability to speech sound disorder
The study of zebrafish mutants of the ASD (show ARSD Antibodies) risk gene, CNTNAP2, and its differential responses to psychoactive agents reveals the strength of this approach to identify molecular mechanisms
Deletions within CNTNAP2 were found in two children with CAS (show CSE1L Antibodies) but not in any of the children with SLI (show SHC2 Antibodies). These findings suggest that genetic variation within CNTNAP2 may be related to speech production deficits.
A genetic and functional characterization study of the CNTNAP2 promoter in autism spectrum disorders
A new male-specific association with aging is reported for a CNV in the CNTNAP2 gene. esv11910 ins (show INS Antibodies) allele was inversely associated with healthy aging in men.
We find no evidence for statistically significant association of rare heterozygous mutations in any of the CNTN (show CNTN1 Antibodies) or CNTNAP (show CNTNAP1 Antibodies) genes, including CNTNAP2, placing marked limits on the scale of their plausible contribution to risk.
After middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs. In addition, there is suppression of the language-associated transcription factor,contactin-associated protein 2 (Cntnap2).
Olfaction-based behavioral tests revealed that mice lacking Caspr2 exhibit abnormal response to sensory stimuli and lack preference for novel odors.
Mice with the Cntnap2 genetic mutation showed a dissociation of auditory-processing abilities
Study reports behavioral characterization of mouse models of autism with null mutation in Cntnap2 gene. It shows hyperactivity, mild gait phenotype and reduced vocalizations among others.
new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry
Cntnap2 deletion selectively impairs perisomatic hippocampal inhibition while sparing excitation provide additional support for synaptic dysfunction as a common mechanism underlying autism spectrum disorders
The CASPR2/MUPP1 (show MPDZ Antibodies) receptor complex co-localized with GPR37 (show GPR37 Antibodies) in hippocampal neurons.
Interaction proteomics revealed the interactors of Caspr2, including CNTN2 (show CNTN2 Antibodies), KCNAs, members of the ADAM family (ADAM22 (show ADAM22 Antibodies), ADAM23 (show Adam23 Antibodies) and ADAM11 (show ADAM11 Antibodies)), members of LGI family and MAGUKs (DLGs and MPPs (show MPHOSPH6 Antibodies)).
CNTNAP2 has a role in the correct trafficking of GluA1 (show GRIA1 Antibodies) AMPA (show GRIA3 Antibodies)-type glutamate (show GRIN1 Antibodies) receptors
Caspr2 is required for paranodal clustering of Kv1 (show KCNA5 Antibodies) channels in the absence of Caspr (show CNTNAP1 Antibodies). Absence of both Caspr (show CNTNAP1 Antibodies) and Caspr2 results in the widening of the nodes of Ranvier.
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
cell recognition molecule Caspr2
, contactin associated protein-like 2
, novel protein similar to H.sapiens contactin associated protein
, contactin associated protein 2
, contactin-associated protein-like 2
, contactin-associated protein-like 2-like
, homolog of Drosophila neurexin IV