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COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009].. Additionally we are shipping COMMD1 Antibodies (69) and COMMD1 Kits (12) and many more products for this protein.
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Human COMMD1 Protein expressed in Escherichia coli (E. coli) - ABIN667798
Müller, van de Sluis, Zhernakova, van Binsbergen, Janecke, Bavdekar, Pandit, Weirich-Schwaiger, Witt, Ellemunter, Deutsch, Denk, Müller, Sternlieb, Tanner, Wijmenga: The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. in Journal of hepatology 2003
Show all 2 references for ABIN667798
Liver specific Commd1 knockout results in elevated plasma LDL cholesterol.
Alteration of COMMD1 concentration influences copper and zinc homeostasis as well as ProSAP/Shank (show SHANK2 Proteins) protein levels.
Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.
results provide the first genetic evidence for COMMD1 to play an essential role in hepatic copper homeostasis and present a valuable mouse model for further understanding of the molecular mechanisms underlying hepatic copper homeostasis
Clusterin (show CLU Proteins) and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A (show ATP7A Proteins) and ATP7B (show ATP7B Proteins).
COMMD1 as a novel protein regulating SOD1 activation and associate COMMD1 function with the production of free radicals.
COMMD1 is required to shuttle the liver copper transporter (Atp7b (show ATP7B Proteins)) when the intracellular copper level falls below the threshold.
RNA polymerase II phosphorylated at serine 2 of the carboxyl-terminal domain repeats, a marker of transcription elongation, is enriched on the paternal allele than on the maternal allele in the Commd1 promoter
Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells
A novel transcript (U2mu) in mouse is transcribed from the portions of two independent genes, U2af1-rs1 and Murr1.
The COMMD1 downregulation by miR (show MLXIP Proteins)-205 promotes tumor development by modulating a positive feedback loop that amplifies inflammatory- and stemness-associated properties of cancer cells.
COMMD1 plays a critical role in the termination of NF-kappaB (show NFKB1 Proteins) activity and the control of pro-inflammatory and pro-labor mediators.
COMMD1 expression is associated with poor prognosis in diffuse large B-cell lymphoma
COMMD1 is identified as a novel regulator of misfolded protein aggregation.
COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62.
COMMD1 is acetylated by p300 (show EP300 Proteins) and that acetylation protects COMMD1 from XIAP (show XIAP Proteins)-mediated proteosomal degradation
IkappaB-alpha (show NFKBIA Proteins) protein was stabilized by COMMD1, which attenuated NF-kappaB (show NFKB1 Proteins) signaling during Toll (show TLR4 Proteins)-like receptor ligand and tumor necrosis factor alpha (show TNF Proteins) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
These data demonstrate the anti-inflammatory properties of COMMD1 in bronchial epithelial cells and open new therapeutic avenues in cystic fibrosis (show S100A8 Proteins).
Placental COMMD1 expression is increased in women with severe preeclampsia compared to that found in women with normal pregnancies.
The role of COMMD1 in copper metabolism and it structure and function are discussed.
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005
copper metabolism (Murr1) domain containing 1
, COMM domain-containing protein 1
, U2af1-rs1 region 1
, copper metabolism domain containing 1
, protein Murr1
, copper metabolism gene MURR1