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Copper Metabolism (Murr1) Domain Containing 1 Proteins (COMMD1)

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009].. Additionally we are shipping COMMD1 Antibodies (68) and COMMD1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COMMD1 17846 Q8K4M5
COMMD1 150684 Q8N668
Rat COMMD1 COMMD1 289831  
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Top COMMD1 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

COMMD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced COMMD1 Proteins

  1. Human COMMD1 Protein expressed in Escherichia coli (E. coli) - ABIN667798 : Müller, van de Sluis, Zhernakova, van Binsbergen, Janecke, Bavdekar, Pandit, Weirich-Schwaiger, Witt, Ellemunter, Deutsch, Denk, Müller, Sternlieb, Tanner, Wijmenga: The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. in Journal of hepatology 2003 (PubMed)
    Show all 2 references for ABIN667798

More Proteins for Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) Interaction Partners

Mouse (Murine) Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) interaction partners

  1. Liver specific Commd1 knockout results in elevated plasma LDL cholesterol.

  2. Alteration of COMMD1 concentration influences copper and zinc homeostasis as well as ProSAP/Shank (show SHANK2 Proteins) protein levels.

  3. Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.

  4. results provide the first genetic evidence for COMMD1 to play an essential role in hepatic copper homeostasis and present a valuable mouse model for further understanding of the molecular mechanisms underlying hepatic copper homeostasis

  5. Clusterin (show CLU Proteins) and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A (show ATP7A Proteins) and ATP7B (show ATP7B Proteins).

  6. COMMD1 as a novel protein regulating SOD1 activation and associate COMMD1 function with the production of free radicals.

  7. COMMD1 is required to shuttle the liver copper transporter (Atp7b (show ATP7B Proteins)) when the intracellular copper level falls below the threshold.

  8. RNA polymerase II phosphorylated at serine 2 of the carboxyl-terminal domain repeats, a marker of transcription elongation, is enriched on the paternal allele than on the maternal allele in the Commd1 promoter

  9. Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells

  10. A novel transcript (U2mu) in mouse is transcribed from the portions of two independent genes, U2af1-rs1 and Murr1.

Human Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) interaction partners

  1. COMMD1 expression is associated with poor prognosis in diffuse large B-cell lymphoma

  2. COMMD1 is identified as a novel regulator of misfolded protein aggregation.

  3. COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62.

  4. COMMD1 is acetylated by p300 (show EP300 Proteins) and that acetylation protects COMMD1 from XIAP (show XIAP Proteins)-mediated proteosomal degradation

  5. IkappaB-alpha (show NFKBIA Proteins) protein was stabilized by COMMD1, which attenuated NF-kappaB (show NFKB1 Proteins) signaling during Toll (show TLR4 Proteins)-like receptor ligand and tumor necrosis factor alpha (show TNF Proteins) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.

  6. These data demonstrate the anti-inflammatory properties of COMMD1 in bronchial epithelial cells and open new therapeutic avenues in cystic fibrosis (show S100A8 Proteins).

  7. Placental COMMD1 expression is increased in women with severe preeclampsia compared to that found in women with normal pregnancies.

  8. The role of COMMD1 in copper metabolism and it structure and function are discussed.

  9. The results indicate a role for COMMD1 in the regulation of NKCC1 (show SLC12A2 Proteins) membrane expression and ubiquitination.

  10. No major role can be attributed to Atox1 (show ATOX1 Proteins) and COMMD in the pathophysiology or clinical variation of Wilson disease.

COMMD1 Protein Profile

Protein Summary

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005

Gene names and symbols associated with COMMD1

  • copper metabolism (Murr1) domain containing 1 (COMMD1)
  • copper metabolism (Murr1) domain containing 1 (commd1)
  • COMM domain containing 1 (Commd1)
  • copper metabolism (Murr1) domain containing 1 (Commd1)
  • AI256843 protein
  • C2orf5 protein
  • COMMD1 protein
  • MGC114682 protein
  • MURR1 protein
  • U2/Mu protein

Protein level used designations for COMMD1

copper metabolism (Murr1) domain containing 1 , MURR1 , COMM domain-containing protein 1 , U2af1-rs1 region 1 , copper metabolism domain containing 1 , protein Murr1 , copper metabolism gene MURR1

GENE ID SPECIES
459266 Pan troglodytes
734503 Xenopus laevis
748450 Pan troglodytes
769006 Gallus gallus
779529 Xenopus (Silurana) tropicalis
17846 Mus musculus
150684 Homo sapiens
534683 Bos taurus
403590 Canis lupus familiaris
289831 Rattus norvegicus
100731728 Cavia porcellus
101117656 Ovis aries
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