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The protein encoded by CPOX is the sixth enzyme of the heme biosynthetic pathway. Additionally we are shipping Coproporphyrinogen Oxidase Antibodies (28) and many more products for this protein.
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The monomer form of mutated CPOX did not show any activity and homodimeric enzymes derived from Hereditary coproporphyria (HCP (show AMBP Proteins)) mutant showed low activity (<20% of the control).
Polymorphism of coproporphyrinogen oxidase is associated with genetic susceptibility to the adverse neurobehavioral effects of Hg exposure in children.
Deletion of the fifth exon in the CPOX gene is associated with hereditary coproporphyria.
CPOX polymorphisms are associated with biological media contamination and apoptosis disorders.
competitive action of both uroporphyrinogen decarboxylase (show UROD Proteins) and CPO on the same diacetate porphyrinogen substrate provides additional perspectives on the potential existence of abnormal pathways for heme biosynthesis
disease-producing mutations in the CPO gene in nine Swedish families with hereditary coproporphyria
coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase (show UOX Proteins)
Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using CPO.
All other type of mutations or missense mutations mapped elsewhere throughout the CPO gene, lead to coproporphyrin accumulation and subsequently typical HCP (show AMBP Proteins).
CPO mutations form the structural basis of hereditary coproporphyria.
The mechanisms by which impairment of CPOX leads to lens opacity in the NCT (show NCSTN Proteins) are elusive. However, our data illuminate a hitherto unanticipated involvement of the heme biosynthesis pathway in lens physiology.
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).
coproporphyrinogen-III oxidase, mitochondrial
, coproporphyrinogen oxidase
, coproporphyrinogen-III oxidase, mitochondrial-like
, Coproporphyrinogen oxidase
, coprogen oxidase
, Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX)
, clone 560