You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antibodies

In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBFA2T2 296293  
CBFA2T2 12396 O70374
CBFA2T2 9139 O43439
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate WB Suggested Anti-CBFA2T2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate  CBFA2T2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB CBFA2T2 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35µg/lane).This demonstrates the CBFA2T2 antibody detected the CBFA2T2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Mouse Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2, antibody at 1:200 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IF, WB Fluorescent image of Hela cell stained with CBFA2T2 Antibody (N-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CBFA2T2 immunoreactivity is localized to Nucleus significantly.Fluorescent image of Hela cell stained with CBFA2T2 Antibody (N-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CBFA2T2 immunoreactivity is localized to Nucleus significantly.Fluorescent image of Hela cell stained with CBFA2T2 Antibody (N-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CBFA2T2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CBFA2T2 immunoreactivity is localized to Nucleus significantly. CBFA2T2 Antibody (N-term)  western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CBFA2T2 antibody detected the CBFA2T2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated DB, ICC, FACS, WB HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-CBFA2T2 antibody (shaded) or isotype control (unshaded) followed by Alexa Fluor 488 conjugated goat anti-mouse IgG. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were stained with anti-CBFA2T2 antibody. 50 μg Log in to see 7 to 9 Days
$285.71
Details
Human Sheep Un-conjugated WB   0.25 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

CBFA2T2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) ,
,
,
, , , , , , , , , , ,
Mouse (Murine) , ,
,
,
, , , , , , , , , , ,
Human , , , ,
, ,
,
, , , , , , , , , , , , , ,

Top referenced anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies

  1. Human Polyclonal CBFA2T2 Primary Antibody for EIA, WB - ABIN951073 : Guastadisegni, Lonoce, Impera, Di Terlizzi, Fugazza, Aliano, Grasso, Cluzeau, Raynaud, Rocchi, Storlazzi: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. in Leukemia 2010 (PubMed)
    Show all 2 references for ABIN951073

  2. Human Polyclonal CBFA2T2 Primary Antibody for WB - ABIN2780644 : Kumar, Manning, Spendlove, Kremmidiotis, McKirdy, Lee, Millband, Cheney, Stampfer, Dwivedi, Morris, Callen: ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. in Molecular cancer research : MCR 2006 (PubMed)

  3. Human Polyclonal CBFA2T2 Primary Antibody for WB - ABIN2780645 : Lyberopoulou, Venieris, Mylonis, Chachami, Pappas, Simos, Bonanou, Georgatsou: MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007 (PubMed)

More Antibodies against Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Interaction Partners

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) interaction partners

  1. This repressive function is mediated through an ETO (show RUNX1T1 Antibodies)-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 (show PRDM14 Antibodies) and co-occupies its genomic targets in mouse embryonic stem cells.

  2. Cbfa2t2(-/-) mice display severe defects in pri (show PRDM14 Antibodies)mordial germ cell maturation and epigenetic reprogramming

  3. MTGR1 is required for tumorigenesis in the murine AOM (show COL2A1 Antibodies)/DSS (show PMP22 Antibodies) colitis-associated carcinoma model.

  4. Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

  5. Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.

  6. c-Myc (show MYC Antibodies), a transcriptional target of the Wnt (show WNT2 Antibodies) pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene (show RAB1A Antibodies)

  7. Eto2 (show CBFA2T3 Antibodies) and Mtgr1 as authentic interaction partners of Tal1 (show TAL1 Antibodies) and suggest they act as heteromeric corepressors of this bHLH transcription factor (show MSGN1 Antibodies) during erythroid differentiation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) interaction partners

  1. CBFA2T2 forms a biochemical complex with PRDM14 (show PRDM14 Antibodies), a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 (show PRDM14 Antibodies) and OCT4 (show POU5F1 Antibodies) are stabilized on chromatin

  2. The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression.

  3. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112

  4. ETO (show RUNX1T1 Antibodies) family member-mediated oligomerization and repression can be distinct events and that interaction between ETO (show RUNX1T1 Antibodies) family members and hSIN3B or N-CoR (show NCOR1 Antibodies) may not necessarily strengthen transcriptional repression.

  5. These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antigen Profile

Protein Summary

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Gene names and symbols associated with CBFA2T2

  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (Cbfa2t2) antibody
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2) antibody
  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2) antibody
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (cbfa2t2) antibody
  • A430091M07 antibody
  • C330013D05Rik antibody
  • cbfa2t2-a antibody
  • Cbfa2t2h antibody
  • EHT antibody
  • MTGR1 antibody
  • p85 antibody
  • XETOR antibody
  • ZMYND3 antibody

Protein level used designations for CBFA2T2

translocated to, 2 , myeloid translocation gene-related protein 1 , protein CBFA2T2 , CBFA2T2 identified gene homolog , MTG8-like protein , MTG8-related protein 1 , core-binding factor runt domain alpha subunit 2 translocated to 2 homolog , core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog , ETO homolog on chromosome 20 , ETO homologous on chromosome 20 , myeloid translocation-related protein 1 , a subunit 2; translocated to, 2 , expressed during neurogenesis

GENE ID SPECIES
296293 Rattus norvegicus
419155 Gallus gallus
12396 Mus musculus
9139 Homo sapiens
379213 Xenopus laevis
Selected quality suppliers for anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antibodies
Did you look for something else?