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CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteins (5) and many more products for this protein.
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MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury.
Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2.
MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury.
Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification.
Data suggest that MTG16 interfaces with critical components of the Notch (show NOTCH1 Antibodies) transcription complex to affect Notch (show NOTCH1 Antibodies)-dependent lineage allocation in hematopoiesis.
association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation
The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.
MTG8/ETO (show RUNX1T1 Antibodies) and Mtg16 (also known as ETO2) associated with TCF4 (show TCF4 Antibodies)
These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 (show GATA1 Antibodies) and SCL (show TAL1 Antibodies).
the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia (show BCL11A Antibodies), is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation.
Analysis of chromatin immunoprecipitation sequencing data sets for MTGR1 (show CBFA2T2 Antibodies) and MTG16 targets indicated that MTGR1 (show CBFA2T2 Antibodies) can regulate Wnt (show WNT2 Antibodies) and Notch (show NOTCH1 Antibodies) signaling.
CBFA2T3 expression is regulated by Med19 (show MED19 Antibodies) in breast cancer cells.
specific interference with ETO2-GLIS2 (show GLIS2 Antibodies) oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.
Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary.
ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.
MTG16 co-repressor promotes degradation of HIF1alpha (show HIF1A Antibodies) in lymphoblasts.
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (show CREBBP Antibodies), CBFA2T3, AMOTL1 (show AMOTL1 Antibodies), FAT4 (show FAT4 Antibodies), FBXO11 (show FBXO11 Antibodies), PLA2G4D, TRRAP (show TRRAP Antibodies) and USH2A (show USH2A Antibodies).
Findings are unprecedented and indicate that the DHH (show DHH Antibodies)-RHEBL1 (show RHEBL1 Antibodies) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2 (show GLIS2 Antibodies)-positive childhood AML (show RUNX1 Antibodies).
Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.
presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso (show ZBTB33 Antibodies) binding to its binding site on DNA, establishing MTG16-Kaiso (show ZBTB33 Antibodies) binding as functionally relevant in Kaiso (show ZBTB33 Antibodies)-dependent transcriptional repression
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\;21)(q24\;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
ETO/MTG8-related protein ETO-2
, MTG8-related protein 2
, core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog; CBFA2T3 identified gene homolog
, eight twenty one protein 2
, myeloid translocation gene-related protein 2
, protein CBFA2T3
, protein ETO-2
, MTG8-related gene 2
, myeloid translocation gene 8 and 16b
, myeloid translocation gene on chromosome 16 protein
, zinc finger MYND domain-containing protein 4
, translocated to, 3