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Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. Additionally we are shipping Cornulin Antibodies (16) and Cornulin Kits (4) and many more products for this protein.
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Human CRNN Protein expressed in Escherichia coli (E. coli) - ABIN666956
Darragh, Hunter, Pohler, Nelson, Dillon, Nenutil, Vojtesek, Ross, Kernohan, Hupp: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury. in The FEBS journal 2006
Show all 2 references for ABIN666956
Results describe the cloning of porcine SEP53, its homology to the human protein, and its expression in the esophagus and in gastric squamous epithelium.
Loss of CRNN expression correlated with advanced tumor length, greater tumor invasion depth, lymph node metastasis, and poor survival in patients with esophageal squamous cell carcinoma.
Findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC.
cornulin is an important molecule in normal esophageal pathology and is likely lost during the conversion of normal to neoplastic epithelium
Negative regulation of SIRT1 (show SIRT1 Proteins) by DBC1 (show DBC1 Proteins) may retard tumorigenesis in breast tissue, so the correlation between SIRT1 (show SIRT1 Proteins) and DBC1 (show DBC1 Proteins) is a potential prognostic indicator in breast cancer.
SEP53 may be a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen
CRNN mRNA expression is decreased in eczematous skin
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
, squamous epithelial induced stress protein 53
, 53 kDa putative calcium-binding protein
, 53 kDa squamous epithelial-induced stress protein
, 58 kDa heat shock protein
, squamous epithelial heat shock protein 53
, tumor-related protein