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CORT encodes a neuropeptide that is structurally similar to somatostatin. Additionally we are shipping CST Antibodies (35) and CST Kits (22) and many more products for this protein.
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GHRL (show GHRL Proteins), LEP (show LEP Proteins), ADIP (show SSX2IP Proteins), INS (show INS Proteins) and CORT concentrations were measured using radioimmunoassay
Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation.
The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed.
Endocrine activities of cortistatin-14 and its interaction with GHRH (show GHRH Proteins) and ghrelin (show GHRL Proteins) in humans.
first extensive study demonstrating that lymphoid tissues and immune cells express different levels of CST (show GAL3ST1 Proteins) mRNA and that its expression can be regulated; hypothesize a role as an endogenous ligand of at least the sst2 (show SSTR2 Proteins) receptor in the immune system
study demonstrates for the first time a selective and inducible expression of the recently discovered cortistatin, as well as somatostatin receptor 2 (show SSTR2 Proteins), in human monocyte-derived cells
cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 (show MRGPRX2 Proteins) which is expressed in dorsal root ganglion
Cortistatin plays a role in the auto/paracrine regulation of the endocrine pancreas
Intravitreous somatostatin (show SST Proteins)-like immunoreactivity deficit occurs in ptients with proliferative diabetic retinopathy.
Human immune cells produce CST (show GAL3ST1 Proteins), whereas macrophage lineage and activated endothelium express sst2 (show SSTR2 Proteins), and human lymphocytes express sst3. The human thymus expresses sst1 (show SSTR1 Proteins), 2, 3, MrgX2 (show MRGPRX2 Proteins) and almost all immune cells express GHS-R (show GHSR Proteins). [review]
A lower expression of CST (show GAL3ST1 Proteins) exists in diabetic retinas and it is associated with retinal neurodegeneration.
Endogenous SST (show SST Proteins) and CORT distinctly impact on DMBA-induced mammary gland tumorigenesis , in a manner that is strongly dependent on the metabolic/endocrine milieu (lean vs. obese status).
This study demonistrated that Cortistatin attenuates inflammatory pain via spinal and peripheral actions.
endogenous CORT is essential for the obesity-induced changes in insulin (show INS Proteins) expression/secretion observed in mice
the role of endogenous CST is different from SST (show SST Proteins); CST exerted an unexpected stimulatory role on prolactin (show PRL Proteins) secretion
Regulation of cortistatin-expressing interneurons by activity-dependent BDNF (show BDNF Proteins) expression may contribute to regulation of sleep behavior.
Cortistatin mRNA concentration in the hippocampus and dentate gyrus is significantly increased in aged non-transgenic (Tg) mice compared with young non-Tg mice.
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739.
, cortistatin preproprotein-like