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Cryptochrome 2 (Photolyase-Like) Proteins (CRY2)

member of a family of blue-light photoreceptors\; may regulate circadian rhythm [RGD, Feb 2006].. Additionally we are shipping CRY2 Antibodies (56) and CRY2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRY2 1408 Q49AN0
CRY2 12953 Q9R194
CRY2 170917 Q923I8
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Top CRY2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Arabidopsis thaliana Arabidopsis Un-conjugated   100 μL Log in to see 2 to 3 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CRY2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Cryptochrome 2 (Photolyase-Like) (CRY2) Interaction Partners

Arabidopsis thaliana Cryptochrome 2 (Photolyase-Like) (CRY2) interaction partners

  1. For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.

  2. Arabidopsis thaliana cry2 proteins containing Trp (show TBPL1 Proteins) triad mutations indeed undergo robust photoreduction in living cultured insect cells.

  3. data showed that mutations in the serine residues within and outside the serine cluster diminished blue light-dependent CRY2 phosphorylation, degradation, and physiological activities.

  4. Our study demonstrates that CIBs function redundantly in regulating CRY2-dependent flowering, and that different CIBs form heterodimers to interact with the non-canonical E-box DNA in vivo.

  5. Studies show that CK1.3 (At4g28880) and CK1.4 (At4g28860) directly phosphorylate CRY2 at Ser (show SIGLEC1 Proteins)-587 and Thr (show TRH Proteins)-603 in vitro and negatively regulate CRY2 stability, which are stimulated by blue light.

  6. Based on the loss of degradation of cry2 after prolonged darkness and loss of reversibility of photoactivated cry1 (show CRY1 Proteins) by a pulse of green light, we estimate the in vivo half-lives of the signaling states of cry1 (show CRY1 Proteins) and cry2 to be in the range of 5 and 16 min.

  7. Data indicate that although cryptochrome 2 physically interacts with CIB1 (show CIB1 Proteins) in response to blue light, ZEITLUPE and LOV KELCH PROTEIN 2 are required for the function and blue-light suppression of degradation of CIB1 (show CIB1 Proteins).

  8. fusing AtCRY2 to the TopBP1 (show TOPBP1 Proteins) DNA damage checkpoint protein, light-induced AtCRY2 PBs (show TSPO Proteins) can be used to activate DNA damage signaling pathway in the absence of DNA damage

  9. Data indicate that the green light (GL) opposition of red light (RL) responses persists in phyA, phyB, cry1cry2 and phot2 mutants, and the response requires phot1 and NPH3.

  10. Degradation of Arabidopsis CRY2 is regulated by SPA1, Spa2, Spa4 proteins and phytochrome A.

Human Cryptochrome 2 (Photolyase-Like) (CRY2) interaction partners

  1. Given the distinct characteristics of the C-terminal tails of the CRY1 (show CRY1 Proteins) and CRY2 proteins, our study addresses a long-standing hypothesis that the ratio of these two CRY molecules affects the clock period.

  2. data may point to CRY2 as a novel switch in hepatic fuel metabolism promoting triglyceride storage and, concomitantly, limiting glucose production

  3. Data indicate that cryptochrome 2 (CRY2) knockdown leads to chemosensitivity of colorectal cancer cell lines.

  4. CRY2 and REV-ERB ALPHA (show NR1D1 Proteins) as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA (show NR1D1 Proteins) is an important gene associated with MS.

  5. these observations suggest a biologically plausible season-dependent association between SNPs at CRY1, CRY2 and MTNR1B and glucose homeostasis.

  6. CRY1 (show CRY1 Proteins) and CRY2 variants showed nominal association with the metabolic syndrome components, hypertension and triglyceride levels.

  7. These findings suggest that the core circadian gene CRY2 is associated with breast cancer progression and prognosis, and that knockdown of CRY2 causes the epigenetic dysregulation of genes involved in cancer-relevant pathways

  8. CRY2 genetic variants associate with the depressive episodes in a range of mood disorder; CRY2 is hypothesized to a key to the resetting of clocks throughout and play a leading role in the antidepressant effect of total sleep deprivation

  9. Four CRY2 genetic variants (rs10838524, rs7121611, rs7945565, rs1401419) associated significantly with dysthymia (false discovery rate q<0.05).

  10. Our data indicate that variants in the circadian-related genes CRY2 and MTNR1B may affect long-term changes in energy expenditure, and dietary fat intake may modify the genetic effects.

Mouse (Murine) Cryptochrome 2 (Photolyase-Like) (CRY2) interaction partners

  1. Data show that cryptochrome Cry1 (show CRY1 Proteins) and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP (show AVP Proteins)) receptor signaling is required to impose circuit-level circadian function.

  2. Data suggest that cryptochromes (Cry1 (show CRY1 Proteins) and Cry2) mediate periodic binding of Ck2b (show CSNK2B Proteins) (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Proteins) protein) and thus inhibit Bmal1 (show ARNTL Proteins)-Ser90 phosphorylation by Ck2a (show CSNK2A1 Proteins) (casein kinase 2alpha).

  3. Cry2 exerts a critical role in the control of depression-related emotional states and modulates the chronobiological gene expression profile in the mouse amygdala.

  4. Cry1/Cry2-deficient mice had significantly lower N6- methyladenosine methylation of RNA and lost the circadian rhythm of N6-methyladenosine levels in RNA.

  5. Data show that the intermolecular zinc finger is important for period circadian protein (PER2 (show PER2 Proteins))-cryptochrome 2 (CRY2) complex formation.

  6. Report compression of daily activity time in Cry2 mutant mice.

  7. Data show that Ser557 phosphorylation of CRY2 promotes CRY2 degradation and inhibits the overaccumulation of the CRY2-PER2 (show PER2 Proteins) complex in the nucleus.

  8. the daily dissonance between peripheral clocks and the environment did not affect the lifespan of Cry1 (show CRY1 Proteins)(-/-) or Cry2(-/-) mice.

  9. Demonstrate opposing actions for Cry2 and Per1 on Per1 target genes, supporting the potential Cry2-Clock/Bmal1-dependent mechanism underlying Per1 action in the liver and kidney.

  10. Cry2 knockout mice are susceptible to diet-induced obesity.

CRY2 Protein Profile

Protein Summary

member of a family of blue-light photoreceptors\; may regulate circadian rhythm

Gene names and symbols associated with CRY2

  • cryptochrome 2 (photolyase-like) (CRY2)
  • cryptochrome 2 (Cry2)
  • cryptochrome Cry2 (cry2)
  • cryptochrome 2 (cry2)
  • cryptochrome 2 (LOC100502533)
  • cryptochrome 2 (photolyase-like) (LOC100224803)
  • cryptochrome 2 (CRY2)
  • cryptochrome 2 (photolyase-like) (Cry2)
  • cryptochrome-2-like (LOC509058)
  • AT-PHH1 protein
  • ATCRY2 protein
  • AV006279 protein
  • Cry protein
  • CRY2 protein
  • cryptochrome 2 protein
  • D130054K12Rik protein
  • F19P19.14 protein
  • F19P19_14 protein
  • FHA protein
  • GB10211 protein
  • gCry2 protein
  • HCRY2 protein
  • PHH1 protein
  • PHLL2 protein

Protein level used designations for CRY2

cryptochrome-2 , cryptochrome 2 , cryptochrome Cry2 , cryptochrome 2 (photolyase-like) , cryptochrome-2-like , growth-inhibiting protein 37

100169934 Ovis aries
410197 Apis mellifera
5136164 Vibrio cholerae O395
100422810 Xenopus (Silurana) tropicalis
100500922 Bombyx mori
100502533 Zea mays
742186 Pan troglodytes
100008575 Meleagris gallopavo
100075977 Ornithorhynchus anatinus
100224803 Taeniopygia guttata
100404450 Callithrix jacchus
100459065 Pongo abelii
100474141 Ailuropoda melanoleuca
839529 Arabidopsis thaliana
1408 Homo sapiens
12953 Mus musculus
170917 Rattus norvegicus
374092 Gallus gallus
483641 Canis lupus familiaris
100517750 Sus scrofa
509058 Bos taurus
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