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anti-Cullin 2 (CUL2) Antibodies

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Additionally we are shipping Cullin 2 Kits (12) and Cullin 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CUL2 8453 Q13617
CUL2 71745 Q9D4H8
CUL2 361258  
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Top anti-Cullin 2 Antibodies at

Showing 10 out of 123 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CUL2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:3... 100 μL Log in to see 2 to 3 Days
Cow Goat Un-conjugated EIA, WB AP20122PU-N CUL2 antibody staining of NIH3T3 lysate at 1 µg/ml (RIPA b... 0.1 mg Log in to see 6 to 8 Days
Dog Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of CUL-2 on a Jurkat cell lysate (Human T-cell l... Immunofluorescence staining of human endothelial cells. 50 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated EIA, IP, WB Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs)... 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IP, WB Anti-CUL2 antibody was diluted 1:500 to detect CUL2 in human prostate ... 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from LOVO cells, using Cullin 2 Anti... Immunohistochemistry analysis of paraffin-embedded human lung carcinom... 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Anti-CUL2 / Cullin 2 antibody IHC staining of human testis. Immunohist... 50 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB Anti-Cullin 2 antibody, Western blotting Lane 1: A431 Cell Lysate Lane... Lane 3: Recombinant Human Cul2 Protein 2.5ng 100 μg Log in to see 4 to 6 Days

CUL2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cullin 2 Antibodies

  1. Human Polyclonal Cullin 2 Primary Antibody for EIA, IP - ABIN117948 : Feng, Zhong, Punkosdy, Gu, Zhou, Seabolt, Kipreos: CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. in Nature cell biology 2000 (PubMed)
    Show all 11 references for ABIN117948

  2. Dog (Canine) Monoclonal Cullin 2 Primary Antibody for IF, IP - ABIN968173 : Pause, Lee, Worrell, Chen, Burgess, Linehan, Klausner: The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 2 references for ABIN968173

  3. Human Polyclonal Cullin 2 Primary Antibody for IP, WB - ABIN233771 : Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN233771

  4. Cow (Bovine) Polyclonal Cullin 2 Primary Antibody for EIA, WB - ABIN498035 : Argyropoulos, Stütz, Ilnytska, Rice, Teran-Garcia, Rao, Bouchard, Rankinen: KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. in Physiological genomics 2009 (PubMed)

  5. Cow (Bovine) Polyclonal Cullin 2 Primary Antibody for WB - ABIN2792165 : Huh, Zhou, Hayakawa, Cho, Libermann, Jin, Harper, Munger: Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. in Journal of virology 2007 (PubMed)

More Antibodies against Cullin 2 Interaction Partners

Human Cullin 2 (CUL2) interaction partners

  1. Cullins are a family of NEDD8 (show NEDD8 Antibodies) targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A (show HIF1A Antibodies)), via Cullin-2.

  2. Nevertheless, the identification of the Cul2 box may allow prediction of Cullin specificity for all E4orf6-containing Adenoviridae.

  3. a novel link between the oncoprotein PRAME (show PRAME Antibodies) and the conserved EKC (show TAC4 Antibodies) complex

  4. Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha (show HIF1A Antibodies).

  5. The authors applied protein-complex purification strategies and identified PRAME (show PRAME Antibodies) as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase (show MUL1 Antibodies).

  6. The data suggest that neither HIF1alpha (show HIF1A Antibodies) nor CUL2 mutation may play a central role in HIF1alpha (show HIF1A Antibodies) activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias.

  7. Cullin selection is determined by specific Elongin C (show TCEB1 Antibodies) and Skp1 (show SKP1 Antibodies) sequences

  8. the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB (show RB1 Antibodies) tumor suppressor in HPV16 E7-expressing cells.

  9. CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription.

Cow (Bovine) Cullin 2 (CUL2) interaction partners

  1. Authors show that bovine immunodeficiency virus Vif (show BTG1 Antibodies) interacts with Cullin 2 (CUL2), ELOB (show TCEB2 Antibodies)/C, and RBX1 (show RBX1 Antibodies), but not with CBF-beta (show CBFB Antibodies) or CUL5 (show CUL5 Antibodies), to form a CRL2 (show DAND5 Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) and degrade the restrictive bovine APOBEC3 (show APOBEC3F Antibodies) proteins (A3Z2Z3 and A3Z3 (show APOBEC3F Antibodies)).

Caenorhabditis elegans (C. elegans) Cullin 2 (CUL2) interaction partners

  1. CUL-2 RING E3 ubiquitin-ligase (show MUL1 Antibodies) acts at multiple levels to control germline development; CUL-2 may similarly regulate germline development in other organisms as well.

  2. Results indicate that LRR-1 (show LRR1 Antibodies) acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (CRL2 (show DAND5 Antibodies)(LRR-1 (show LRR1 Antibodies))), which ensures DNA replication integrity.

  3. The C. elegans p97/CDC-48 (show vcp Antibodies)-UFD-1 (show UFD1L Antibodies)-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation.

  4. segregation of the germ plasm involves both stabilization of germline proteins in the germ line and cullin-dependent degradation in the soma

  5. Results establish that zyg-11 and the cullin cul-2 promote the metaphase-to-anaphase transition and M phase exit at meiosis II in Caenorhabditis elegans.

  6. Data show that inactivation of ZYG-11 produces meiotic and polarity reversal defects similar to those observed in CUL-2 mutants, suggesting that the two proteins function in the same pathways.

  7. oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Antibodies) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Antibodies)- and RBX-1 (show RBX1 Antibodies)-CUL-2-based complexes.

  8. TRA-1 is regulated by degradation mediated by a CUL-2-based ubiquitin ligase complex

  9. Fem-1 protein is a substrate-specific adaptor for a CUL-2-based ubiquitin ligase.

  10. MEL-26 levels are kept low by the action of another type of ubiquitin ligase, which contains CUL-2

Cullin 2 (CUL2) Antigen Profile

Protein Summary

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Gene names and symbols associated with anti-Cullin 2 (CUL2) Antibodies

  • Cullin-2 (cul2) antibody
  • cullin 2 (CUL2) antibody
  • cullin-2 (PTRG_05231) antibody
  • cullin-2 (cul-2) (Smp_079740) antibody
  • cullin 2 (cul2) antibody
  • cullin 2 (LOC100221330) antibody
  • cullin 2 (Cul2) antibody
  • Protein CUL-2 (cul-2) antibody
  • 1300003D18Rik antibody
  • 4932411N15Rik antibody
  • AI327301 antibody
  • ATCUL2 antibody
  • cul2 antibody
  • cullin-2 antibody
  • cullin 2 antibody
  • F22D16.2 antibody
  • F22D16_2 antibody
  • fj48a06 antibody
  • LOC100221330 antibody
  • mKIAA4106 antibody
  • wu:fj48a06 antibody

Protein level used designations for anti-Cullin 2 (CUL2) Antibodies

Cullin-2 , CUL-2 , cullin-2 , cullin-2 (cul-2) , cullin 2 , cullin-2-like

100195615 Salmo salar
100174361 Pongo abelii
6343481 Pyrenophora tritici-repentis Pt-1C-BFP
8345692 Schistosoma mansoni
336088 Danio rerio
420467 Gallus gallus
450399 Pan troglodytes
698384 Macaca mulatta
100221330 Taeniopygia guttata
100395340 Callithrix jacchus
100550749 Meleagris gallopavo
8453 Homo sapiens
71745 Mus musculus
361258 Rattus norvegicus
477952 Canis lupus familiaris
535219 Bos taurus
379729 Xenopus laevis
839415 Arabidopsis thaliana
176806 Caenorhabditis elegans
Selected quality suppliers for anti-Cullin 2 (CUL2) Antibodies
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