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Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Additionally we are shipping Cullin 2 Kits (12) and Cullin 2 Proteins (5) and many more products for this protein.
Showing 10 out of 128 products:
Human Polyclonal Cullin 2 Primary Antibody for EIA, IP - ABIN117948
Feng, Zhong, Punkosdy, Gu, Zhou, Seabolt, Kipreos: CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. in Nature cell biology 2000
Show all 11 references for ABIN117948
Dog (Canine) Monoclonal Cullin 2 Primary Antibody for IF, IP - ABIN968173
Pause, Lee, Worrell, Chen, Burgess, Linehan, Klausner: The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 2 references for ABIN968173
Human Polyclonal Cullin 2 Primary Antibody for IP, WB - ABIN233771
Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. in The Journal of biological chemistry 2007
Show all 2 references for ABIN233771
Cow (Bovine) Polyclonal Cullin 2 Primary Antibody for EIA, WB - ABIN498035
Argyropoulos, Stütz, Ilnytska, Rice, Teran-Garcia, Rao, Bouchard, Rankinen: KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. in Physiological genomics 2009
Cow (Bovine) Polyclonal Cullin 2 Primary Antibody for WB - ABIN2792165
Huh, Zhou, Hayakawa, Cho, Libermann, Jin, Harper, Munger: Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. in Journal of virology 2007
Cullins are a family of NEDD8 (show NEDD8 Antibodies) targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A (show HIF1A Antibodies)), via Cullin-2.
Nevertheless, the identification of the Cul2 box may allow prediction of Cullin specificity for all E4orf6-containing Adenoviridae.
a novel link between the oncoprotein PRAME (show PRAME Antibodies) and the conserved EKC (show TAC4 Antibodies) complex
Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha (show HIF1A Antibodies).
The authors applied protein-complex purification strategies and identified PRAME (show PRAME Antibodies) as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase (show MUL1 Antibodies).
The data suggest that neither HIF1alpha (show HIF1A Antibodies) nor CUL2 mutation may play a central role in HIF1alpha (show HIF1A Antibodies) activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias.
Cullin selection is determined by specific Elongin C (show TCEB1 Antibodies) and Skp1 (show SKP1 Antibodies) sequences
the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB (show RB1 Antibodies) tumor suppressor in HPV16 E7-expressing cells.
CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription.
Authors show that bovine immunodeficiency virus Vif (show BTG1 Antibodies) interacts with Cullin 2 (CUL2), ELOB (show TCEB2 Antibodies)/C, and RBX1 (show RBX1 Antibodies), but not with CBF-beta (show CBFB Antibodies) or CUL5 (show CUL5 Antibodies), to form a CRL2 (show DAND5 Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) and degrade the restrictive bovine APOBEC3 (show APOBEC3F Antibodies) proteins (A3Z2Z3 and A3Z3 (show APOBEC3F Antibodies)).
CUL-2 RING E3 ubiquitin-ligase (show MUL1 Antibodies) acts at multiple levels to control germline development; CUL-2 may similarly regulate germline development in other organisms as well.
Results indicate that LRR-1 (show LRR1 Antibodies) acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (CRL2 (show DAND5 Antibodies)(LRR-1 (show LRR1 Antibodies))), which ensures DNA replication integrity.
The C. elegans p97/CDC-48 (show vcp Antibodies)-UFD-1 (show UFD1L Antibodies)-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation.
segregation of the germ plasm involves both stabilization of germline proteins in the germ line and cullin-dependent degradation in the soma
Results establish that zyg-11 and the cullin cul-2 promote the metaphase-to-anaphase transition and M phase exit at meiosis II in Caenorhabditis elegans.
Data show that inactivation of ZYG-11 produces meiotic and polarity reversal defects similar to those observed in CUL-2 mutants, suggesting that the two proteins function in the same pathways.
oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Antibodies) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Antibodies)- and RBX-1 (show RBX1 Antibodies)-CUL-2-based complexes.
TRA-1 is regulated by degradation mediated by a CUL-2-based ubiquitin ligase complex
Fem-1 protein is a substrate-specific adaptor for a CUL-2-based ubiquitin ligase.
MEL-26 levels are kept low by the action of another type of ubiquitin ligase, which contains CUL-2
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
, cullin-2 (cul-2)
, cullin 2