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anti-Cullin 4A (CUL4A) Antibodies

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Cullin 4A Kits (9) and Cullin 4A Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CUL4A 8451 Q13619
CUL4A 99375 Q3TCH7
CUL4A 361181  
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Top anti-Cullin 4A Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of CUL4a (arrow) using rabbit polyclonal CUL4a Antibody (Human N-term) (ABIN391852).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CUL4a gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of CUL4A (arrow) using rabbit polyclonal CUL4A Antibody (N-term) (ABIN657794). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CUL4A gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CUL4a (arrow) using rabbit polyclonal CUL4a Antibody 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), IP, WB Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references below. 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IP, WB Immunohistochemistry. anti-CUL4 antibody was diluted 1:500 to detect CUL4 in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. 100 μL Log in to see 2 to 3 Days
$369.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CUL4A AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC (p), IP, ELISA, WB Human Testis (formalin-fixed, paraffin-embedded) stained with CUL4A antibody ABIN218509 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB 0.05 mL Log in to see 2 to 3 Days
$481.25
Details

CUL4A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cullin 4A Antibodies

  1. Human Polyclonal Cullin 4A Primary Antibody for EIA, IHC (p) - ABIN117950 : Chen, Manjeshwar, Lu, Moore, Ljung, Kuo, Dairkee, Wernick, Collins, Smith: The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. in Cancer research 1998 (PubMed)
    Show all 11 references for ABIN117950

  2. Human Polyclonal Cullin 4A Primary Antibody for IP, WB - ABIN233773 : Leung-Pineda, Huh, Piwnica-Worms: DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. in Cancer research 2009 (PubMed)
    Show all 4 references for ABIN233773

  3. Human Polyclonal Cullin 4A Primary Antibody for EIA, WB - ABIN359763 : Huang, Chen: VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. in Oncogene 2008 (PubMed)
    Show all 3 references for ABIN359763

  4. Human Polyclonal Cullin 4A Primary Antibody for WB - ABIN391852 : Hu, Zacharek, He, Lee, Shumway, Duronio, Xiong: WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. in Genes & development 2008 (PubMed)
    Show all 3 references for ABIN391852

  5. Human Polyclonal Cullin 4A Primary Antibody for WB - ABIN657794 : Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. in Cancer cell 2010 (PubMed)
    Show all 3 references for ABIN657794

More Antibodies against Cullin 4A Interaction Partners

Zebrafish Cullin 4A (CUL4A) interaction partners

  1. Results show that cul4a but not cul4b (show CUL4B Antibodies) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Human Cullin 4A (CUL4A) interaction partners

  1. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  2. this study proposes that inflammation-induced Jak (show JAK3 Antibodies)-STAT3 (show STAT3 Antibodies) signaling leads to colon cancer development through proteasomal degradation of DICER1 (show DICER1 Antibodies) by ubiquitin ligase complex of CUL4A(DCAF1 (show VPRBP Antibodies)), which suggests a novel therapeutic opportunity for colon cancer

  3. We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI (show TGFBI Antibodies) in lung cancer cells.

  4. Amplification of CUL4A, IRS2 (show IRS2 Antibodies), and TFDP1 (show TFDP1 Antibodies) genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.

  5. These results suggest a linkage between Cul4A and Gli1 (show GLI1 Antibodies) expression in human mesothelioma.

  6. Our results indicate that CUL4A overexpression play an oncogenic role in the pathogenesis of prostate cancer (PC), and CUL4A may be a potential therapeutic target for PCa (show FLVCR1 Antibodies).

  7. Our data are consistent with the idea that the CUL4A/B-DDB1 (show DDB1 Antibodies)-CRBN (show CRBN Antibodies) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Antibodies) channels.

  8. PR-Set7 (show SETD8 Antibodies) is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.

  9. Results show that CUL4A- and CUL4B (show CUL4B Antibodies)-mediated polyubiquitination of gamma-tubulin (show TUBG1 Antibodies) for its degradation.

  10. CUL4A regulated EGFR (show EGFR Antibodies) transcriptional expression.

Mouse (Murine) Cullin 4A (CUL4A) interaction partners

  1. These studies identify CUL4-DDB1 (show DDB1 Antibodies) complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  2. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  3. Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.

  4. this study revealed an indispensable role for Cul4a during male germ cell meiosis.

  5. The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (show CUL4B Antibodies) gene is silenced due to meiotic sex chromosome inactivation.

  6. CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.

  7. Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.

  8. a Cul4A ubiquitin ligase (show RNF123 Antibodies) positively regulates proliferation by targeting p27 (show CDKN1B Antibodies) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (show CDKN1B Antibodies) to accumulate and signal cell cycle exit

  9. Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity

  10. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure

Cullin 4A (CUL4A) Antigen Profile

Protein Summary

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009

Gene names and symbols associated with anti-Cullin 4A (CUL4A) Antibodies

  • cullin 4A (CUL4A) antibody
  • cullin 4A (cul4a) antibody
  • cullin 4A (Cul4a) antibody
  • 2810470J21Rik antibody
  • AW495282 antibody
  • CUL4A antibody
  • RGD1563853 antibody
  • zgc:64071 antibody

Protein level used designations for anti-Cullin 4A (CUL4A) Antibodies

cullin 4A , cullin-4A-like , CUL-4A , cullin-4A

GENE ID SPECIES
100033930 Equus caballus
394002 Danio rerio
452694 Pan troglodytes
548647 Xenopus (Silurana) tropicalis
607683 Canis lupus familiaris
100411111 Callithrix jacchus
100453992 Pongo abelii
100470988 Ailuropoda melanoleuca
100549149 Meleagris gallopavo
100579811 Nomascus leucogenys
8451 Homo sapiens
99375 Mus musculus
361181 Rattus norvegicus
418744 Gallus gallus
100517912 Sus scrofa
617935 Bos taurus
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