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CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Cullin 4A Kits (9) and Cullin 4A Proteins (5) and many more products for this protein.
Showing 10 out of 75 products:
Human Polyclonal Cullin 4A Primary Antibody for EIA, IHC (p) - ABIN117950
Chen, Manjeshwar, Lu, Moore, Ljung, Kuo, Dairkee, Wernick, Collins, Smith: The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. in Cancer research 1998
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Human Polyclonal Cullin 4A Primary Antibody for IP, WB - ABIN233773
Leung-Pineda, Huh, Piwnica-Worms: DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. in Cancer research 2009
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Human Polyclonal Cullin 4A Primary Antibody for EIA, WB - ABIN359763
Huang, Chen: VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. in Oncogene 2008
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Human Polyclonal Cullin 4A Primary Antibody for WB - ABIN391852
Hu, Zacharek, He, Lee, Shumway, Duronio, Xiong: WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. in Genes & development 2008
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Human Polyclonal Cullin 4A Primary Antibody for WB - ABIN657794
Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. in Cancer cell 2010
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Results show that cul4a but not cul4b (show CUL4B Antibodies) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.
this study proposes that inflammation-induced Jak (show JAK3 Antibodies)-STAT3 (show STAT3 Antibodies) signaling leads to colon cancer development through proteasomal degradation of DICER1 (show DICER1 Antibodies) by ubiquitin ligase complex of CUL4A(DCAF1 (show VPRBP Antibodies)), which suggests a novel therapeutic opportunity for colon cancer
We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI (show TGFBI Antibodies) in lung cancer cells.
Amplification of CUL4A, IRS2 (show IRS2 Antibodies), and TFDP1 (show TFDP1 Antibodies) genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.
These results suggest a linkage between Cul4A and Gli1 (show GLI1 Antibodies) expression in human mesothelioma.
Our results indicate that CUL4A overexpression play an oncogenic role in the pathogenesis of prostate cancer (PC), and CUL4A may be a potential therapeutic target for PCa (show FLVCR1 Antibodies).
Our data are consistent with the idea that the CUL4A/B-DDB1 (show DDB1 Antibodies)-CRBN (show CRBN Antibodies) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Antibodies) channels.
PR-Set7 (show SETD8 Antibodies) is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.
Results show that CUL4A- and CUL4B (show CUL4B Antibodies)-mediated polyubiquitination of gamma-tubulin (show TUBG1 Antibodies) for its degradation.
CUL4A regulated EGFR (show EGFR Antibodies) transcriptional expression.
These studies identify CUL4-DDB1 (show DDB1 Antibodies) complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.
Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.
this study revealed an indispensable role for Cul4a during male germ cell meiosis.
The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (show CUL4B Antibodies) gene is silenced due to meiotic sex chromosome inactivation.
CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.
Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.
a Cul4A ubiquitin ligase (show RNF123 Antibodies) positively regulates proliferation by targeting p27 (show CDKN1B Antibodies) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (show CDKN1B Antibodies) to accumulate and signal cell cycle exit
Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity
Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009