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Cullin 4A Proteins (CUL4A)

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Cullin 4A Antibodies (75) and Cullin 4A Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CUL4A 8451 Q13619
CUL4A 99375 Q3TCH7
Rat CUL4A CUL4A 361181  
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Top Cullin 4A Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

CUL4A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Cullin 4A (CUL4A) Interaction Partners

Zebrafish Cullin 4A (CUL4A) interaction partners

  1. Results show that cul4a but not cul4b (show CUL4B Proteins) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Human Cullin 4A (CUL4A) interaction partners

  1. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  2. this study proposes that inflammation-induced Jak-STAT3 signaling leads to colon cancer development through proteasomal degradation of DICER1 by ubiquitin ligase complex of CUL4A(DCAF1), which suggests a novel therapeutic opportunity for colon cancer

  3. We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI (show TGFBI Proteins) in lung cancer cells.

  4. Amplification of CUL4A, IRS2 (show IRS2 Proteins), and TFDP1 (show TFDP1 Proteins) genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.

  5. These results suggest a linkage between Cul4A and Gli1 (show GLI1 Proteins) expression in human mesothelioma.

  6. Our results indicate that CUL4A overexpression play an oncogenic role in the pathogenesis of prostate cancer (PC), and CUL4A may be a potential therapeutic target for PCa (show FLVCR1 Proteins).

  7. Our data are consistent with the idea that the CUL4A/B-DDB1 (show DDB1 Proteins)-CRBN (show CRBN Proteins) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Proteins) channels.

  8. PR-Set7 (show SETD8 Proteins) is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.

  9. Results show that CUL4A- and CUL4B (show CUL4B Proteins)-mediated polyubiquitination of gamma-tubulin (show TUBG1 Proteins) for its degradation.

  10. CUL4A regulated EGFR (show EGFR Proteins) transcriptional expression.

Mouse (Murine) Cullin 4A (CUL4A) interaction partners

  1. These studies identify CUL4-DDB1 (show DDB1 Proteins) complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  2. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  3. Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.

  4. this study revealed an indispensable role for Cul4a during male germ cell meiosis.

  5. The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (show CUL4B Proteins) gene is silenced due to meiotic sex chromosome inactivation.

  6. CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.

  7. Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.

  8. a Cul4A ubiquitin ligase (show RNF123 Proteins) positively regulates proliferation by targeting p27 (show CDKN1B Proteins) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (show CDKN1B Proteins) to accumulate and signal cell cycle exit

  9. Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity

  10. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure

Cullin 4A (CUL4A) Protein Profile

Protein Summary

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009

Gene names and symbols associated with Cullin 4A Proteins (CUL4A)

  • cullin 4A (CUL4A)
  • cullin 4A (cul4a)
  • cullin 4A (Cul4a)
  • 2810470J21Rik protein
  • AW495282 protein
  • CUL4A protein
  • RGD1563853 protein
  • zgc:64071 protein

Protein level used designations for Cullin 4A Proteins (CUL4A)

cullin 4A , cullin-4A-like , CUL-4A , cullin-4A

GENE ID SPECIES
100033930 Equus caballus
394002 Danio rerio
452694 Pan troglodytes
548647 Xenopus (Silurana) tropicalis
607683 Canis lupus familiaris
100411111 Callithrix jacchus
100453992 Pongo abelii
100470988 Ailuropoda melanoleuca
100549149 Meleagris gallopavo
100579811 Nomascus leucogenys
8451 Homo sapiens
99375 Mus musculus
361181 Rattus norvegicus
418744 Gallus gallus
100517912 Sus scrofa
617935 Bos taurus
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