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CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Cullin 4A Proteins (5) and many more products for this protein.
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Human Polyclonal Cullin 4A Primary Antibody for IP, WB - ABIN233773
Leung-Pineda, Huh, Piwnica-Worms: DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. in Cancer research 2009
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Human Polyclonal Cullin 4A Primary Antibody for IP - ABIN250652
Vaites, Lee, Lian, Barbash, Roy, Wasik, Klein-Szanto, Rustgi, Diehl: The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. in Molecular and cellular biology 2011
Show all 3 Pubmed References
Human Polyclonal Cullin 4A Primary Antibody for ICC, IF - ABIN250653
Jiang, Rong, Sheikh, Huang: Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. in The Journal of biological chemistry 2011
Show all 2 Pubmed References
Human Polyclonal Cullin 4A Primary Antibody for ELISA, IHC - ABIN4300968
Higa, Mihaylov, Banks, Zheng, Zhang: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. in Nature cell biology 2003
Results show that cul4a but not cul4b (show CUL4B Antibodies) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
knockdown of cullin 4A via small interfering RNA inhibited the proliferation of the multiple myeloma cell lines by delaying cell-cycle progression and increasing apoptosis. cullin 4A downregulation inhibited multiple myeloma cell migration and invasion in vitro. Our results suggested that cullin 4A could be a promising therapy target in multiple myeloma patients
findings revealed that CUL4A and CUL4B (show CUL4B Antibodies) are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes
decreased tumour growth and increased chemosensitivity to gemcitabine were also noted after Cul4A knockdown.
CUL4A played an oncogene (show RAB1A Antibodies) role through ZEB1 (show ZEB1 Antibodies) in IL-6 (show IL6 Antibodies)-induced colorectal carcinoma progression.
Overexpression of miR (show MLXIP Antibodies)-494 inhibited proliferation, migration, invasion and EMT (show ITK Antibodies) of ovarian cancer cells by directly suppressing CUL4A expression. Therefore, our findings indicate that miR (show MLXIP Antibodies)-494/CUL4A axis is important in the control of ovarian cancer tumorigenesis.
CUL4A sensitizes colorectal cancer cells to cisplatin induced cell death.
Elevated expression of CUL4A is positively correlated with distant metastases.
Increased CUL4A expression is associated with osteosarcoma.
Findings indicate the importance of a microRNAs miR (show MLXIP Antibodies)-9/137-CUL4A-Hippo signaling axis in gastric cancer (GC), and suggest new therapeutic targets for future treatment of GC.
CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.
These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.
Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.
this study revealed an indispensable role for Cul4a during male germ cell meiosis.
The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (show CUL4B Antibodies) gene is silenced due to meiotic sex chromosome inactivation.
CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.
Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.
a Cul4A ubiquitin ligase (show RNF123 Antibodies) positively regulates proliferation by targeting p27 (show CDKN1B Antibodies) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (show CDKN1B Antibodies) to accumulate and signal cell cycle exit
Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity
Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009