anti-Cullin 4A (CUL4A) Antibodies

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Cullin 4A Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CUL4A 8451 Q13619
CUL4A 99375 Q3TCH7
CUL4A 361181  
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Top anti-Cullin 4A Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-CUL4A AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CUL4a (arrow) using rabbit polyclonal CUL4a Antibody (Human N-term) (ABIN391852).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CUL4a gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of CUL4A (arrow) using rabbit polyclonal CUL4A Antibody (N-term) (ABIN657794). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CUL4A gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, PLA, WB Immunohistochemistry-Paraffin: Cullin 4a Antibody [ABIN250653] - Human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody used at a dilution of 1:1000 (1ug/ml). 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$357.50
Details
Human Rabbit Un-conjugated IP, WB Immunohistochemistry. anti-CUL4 antibody was diluted 1:500 to detect CUL4 in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. 100 μL Log in to see 1 to 2 Days
$379.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Cullin 4a Antibody [NBP1-78040] - anti-CUL4 antibody was diluted 1:500 to detect CUL4 in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. 0.1 mL Log in to see 7 to 9 Days
$538.13
Details
Human Rabbit Un-conjugated EIA, IHC (p), IP, WB   0.1 mL Log in to see 12 to 15 Days
$411.18
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$323.13
Details

CUL4A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cullin 4A Antibodies

  1. Human Polyclonal Cullin 4A Primary Antibody for IP, WB - ABIN233773 : Leung-Pineda, Huh, Piwnica-Worms: DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. in Cancer research 2009 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal Cullin 4A Primary Antibody for IP - ABIN250652 : Vaites, Lee, Lian, Barbash, Roy, Wasik, Klein-Szanto, Rustgi, Diehl: The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. in Molecular and cellular biology 2011 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Cullin 4A Primary Antibody for ICC, IF - ABIN250653 : Jiang, Rong, Sheikh, Huang: Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. in The Journal of biological chemistry 2011 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Cullin 4A Primary Antibody for ELISA, IHC - ABIN4300968 : Higa, Mihaylov, Banks, Zheng, Zhang: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. in Nature cell biology 2003 (PubMed)

More Antibodies against Cullin 4A Interaction Partners

Zebrafish Cullin 4A (CUL4A) interaction partners

  1. Results show that cul4a but not cul4b (show CUL4B Antibodies) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Human Cullin 4A (CUL4A) interaction partners

  1. knockdown of cullin 4A via small interfering RNA inhibited the proliferation of the multiple myeloma cell lines by delaying cell-cycle progression and increasing apoptosis. cullin 4A downregulation inhibited multiple myeloma cell migration and invasion in vitro. Our results suggested that cullin 4A could be a promising therapy target in multiple myeloma patients

  2. findings revealed that CUL4A and CUL4B (show CUL4B Antibodies) are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes

  3. decreased tumour growth and increased chemosensitivity to gemcitabine were also noted after Cul4A knockdown.

  4. CUL4A played an oncogene (show RAB1A Antibodies) role through ZEB1 (show ZEB1 Antibodies) in IL-6 (show IL6 Antibodies)-induced colorectal carcinoma progression.

  5. Overexpression of miR (show MLXIP Antibodies)-494 inhibited proliferation, migration, invasion and EMT (show ITK Antibodies) of ovarian cancer cells by directly suppressing CUL4A expression. Therefore, our findings indicate that miR (show MLXIP Antibodies)-494/CUL4A axis is important in the control of ovarian cancer tumorigenesis.

  6. CUL4A sensitizes colorectal cancer cells to cisplatin induced cell death.

  7. Elevated expression of CUL4A is positively correlated with distant metastases.

  8. Increased CUL4A expression is associated with osteosarcoma.

  9. Findings indicate the importance of a microRNAs miR (show MLXIP Antibodies)-9/137-CUL4A-Hippo signaling axis in gastric cancer (GC), and suggest new therapeutic targets for future treatment of GC.

  10. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

Mouse (Murine) Cullin 4A (CUL4A) interaction partners

  1. These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  2. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  3. Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.

  4. this study revealed an indispensable role for Cul4a during male germ cell meiosis.

  5. The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (show CUL4B Antibodies) gene is silenced due to meiotic sex chromosome inactivation.

  6. CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.

  7. Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.

  8. a Cul4A ubiquitin ligase (show RNF123 Antibodies) positively regulates proliferation by targeting p27 (show CDKN1B Antibodies) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (show CDKN1B Antibodies) to accumulate and signal cell cycle exit

  9. Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity

  10. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure

Cullin 4A (CUL4A) Antigen Profile

Protein Summary

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009

Gene names and symbols associated with anti-Cullin 4A (CUL4A) Antibodies

  • cullin 4A (CUL4A) antibody
  • cullin 4A (cul4a) antibody
  • cullin 4A (Cul4a) antibody
  • 2810470J21Rik antibody
  • AW495282 antibody
  • CUL4A antibody
  • RGD1563853 antibody
  • zgc:64071 antibody

Protein level used designations for anti-Cullin 4A (CUL4A) Antibodies

cullin 4A , cullin-4A-like , CUL-4A , cullin-4A

GENE ID SPECIES
100033930 Equus caballus
394002 Danio rerio
452694 Pan troglodytes
548647 Xenopus (Silurana) tropicalis
607683 Canis lupus familiaris
100411111 Callithrix jacchus
100453992 Pongo abelii
100470988 Ailuropoda melanoleuca
100549149 Meleagris gallopavo
100579811 Nomascus leucogenys
8451 Homo sapiens
99375 Mus musculus
361181 Rattus norvegicus
418744 Gallus gallus
100517912 Sus scrofa
617935 Bos taurus
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