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CUL4B is a member of the cullin family. Additionally we are shipping Cullin 4B Antibodies (95) and Cullin 4B Proteins (4) and many more products for this protein.
Results show that cul4a (show CUL4A ELISA Kits) but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
The CUL4B interacts with WD-40 proteins through the adaptor protein DNA damage-binding protein 1 (DDB1) to target substrates for ubiquitylation.
This study found that microRNA-194 (miR (show MLXIP ELISA Kits)-194) and CUL4B protein were inversely correlated in cancer specimens and demonstrated that miR (show MLXIP ELISA Kits)-194 could downregulate CUL4B by directly targeting its 3'-UTR (show UTS2R ELISA Kits).
findings revealed that CUL4A (show CUL4A ELISA Kits) and CUL4B are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes
CUL4B regulates protein turnover and homeostasis in response to dopamine stimulation.
CUL4B protein levels in human subcutaneous adipose tissue is negatively correlated with body mass index.
these results suggest that knockdown of CUL4B inhibited the proliferation and invasion through suppressing the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway in NSCLC cells. Therefore, CUL4B may represent a novel therapeutic target for the treatment of NSCLC.
these results showed that knockdown of CUL4B inhibit proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway
Our data are consistent with the idea that the CUL4A (show CUL4A ELISA Kits)/B-DDB1-CRBN (show CRBN ELISA Kits) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 ELISA Kits) channels.
FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.
results established a critical role of CUL4B in negatively regulating the p53 (show TP53 ELISA Kits)-ROS (show ROS1 ELISA Kits) positive feedback loop that drives cellular senescence
A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions
Adipocyte-specific Cul4b knockout (AKO) mice being fed a high-fat diet exhibited increased body fat accumulation that was mediated by increased adipogenesis. However, AKO mice showed improved metabolic phenotypes, including increased insulin (show INS ELISA Kits) sensitivity and glucose tolerance. Correspondingly, there was a decreased inflammatory response in adipose tissues of AKO mice.
CUL4B as a key regulator of post-meiotic sperm morphogenesis
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice
Ptgds (show PTGDS ELISA Kits) is targeted and repressed by the CUL4B/PRC2 complex.
CUL4B knockdown alleviated in vivo tumorigenesis in glioma xenograft nude mice.
Data indicate a role of cullin family, CUL4B, in the immune system.
Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 (show COPS5 ELISA Kits) accumulation.
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.