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CUL4B is a member of the cullin family. Additionally we are shipping Cullin 4B Antibodies (94) and many more products for this protein.
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Results show that cul4a (show CUL4A Proteins) but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
This study found that microRNA-194 (miR-194) and CUL4B protein were inversely correlated in cancer specimens and demonstrated that miR-194 could downregulate CUL4B by directly targeting its 3'-UTR.
findings revealed that CUL4A (show CUL4A Proteins) and CUL4B are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes
CUL4B regulates protein turnover and homeostasis in response to dopamine stimulation.
CUL4B protein levels in human subcutaneous adipose tissue is negatively correlated with body mass index.
these results suggest that knockdown of CUL4B inhibited the proliferation and invasion through suppressing the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway in NSCLC cells. Therefore, CUL4B may represent a novel therapeutic target for the treatment of NSCLC.
these results showed that knockdown of CUL4B inhibit proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway
Our data are consistent with the idea that the CUL4A (show CUL4A Proteins)/B-DDB1-CRBN (show CRBN Proteins) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Proteins) channels.
FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.
results established a critical role of CUL4B in negatively regulating the p53 (show TP53 Proteins)-ROS (show ROS1 Proteins) positive feedback loop that drives cellular senescence
Results demonstrated that CUL4B promotes cell proliferation and inhibits the apoptosis of osteosarcoma cells.
A cullin 4B-RING E3 ligase complex fine-tunes pancreatic delta cell paracrine interactions
Adipocyte-specific Cul4b knockout (AKO) mice being fed a high-fat diet exhibited increased body fat accumulation that was mediated by increased adipogenesis. However, AKO mice showed improved metabolic phenotypes, including increased insulin (show INS Proteins) sensitivity and glucose tolerance. Correspondingly, there was a decreased inflammatory response in adipose tissues of AKO mice.
CUL4B as a key regulator of post-meiotic sperm morphogenesis
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice
Ptgds (show PTGDS Proteins) is targeted and repressed by the CUL4B/PRC2 complex.
CUL4B knockdown alleviated in vivo tumorigenesis in glioma xenograft nude mice.
Data indicate a role of cullin family, CUL4B, in the immune system.
Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 (show COPS5 Proteins) accumulation.
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.