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anti-Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) Antibodies

CNGA3 encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Additionally we are shipping Cyclic Nucleotide Gated Channel alpha 3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CNGA3 1261 Q16281
CNGA3 12790 Q9JJZ8
CNGA3 85257  
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Top anti-Cyclic Nucleotide Gated Channel alpha 3 Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 14 Days
$527.15
Details
Chicken Rabbit Un-conjugated IHC   0.1 mg Log in to see 5 to 7 Days
$330.00
Details
Rat Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$610.50
Details
Rat Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$610.50
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 9 Days
$487.50
Details
Rat Rabbit Un-conjugated IHC 50 μg Log in to see 5 to 6 Days
$398.48
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Mouse kidney and brain tissue, using CNGA3 Polyclonal Antibody at dilution of 1:500 200 μL Log in to see 8 to 9 Days
$588.50
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$369.79
Details

CNGA3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human


Mouse (Murine) ,


Rat (Rattus) ,


Top referenced anti-Cyclic Nucleotide Gated Channel alpha 3 Antibodies

  1. Chicken Polyclonal CNGA3 Primary Antibody for IHC - ABIN965909 : Giorgetti, Nair, Codega, Torre, Carloni: Structural basis of gating of CNG channels. in FEBS letters 2005 (PubMed)
    Show all 7 references for ABIN965909

More Antibodies against Cyclic Nucleotide Gated Channel alpha 3 Interaction Partners

Human Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. The c.955T>C change identified in large consanguineous Pakistani family represents the first variant of CNGA3 which was found to be responsible for the cone-rod dystrophy phenotype.

  2. Among Israeli and Palestinian patients, CNGA3 mutations are the leading cause of achromatopsia. Retinal structural results support the candidacy of CNGA3 ACHM for clinical trials for therapy of cone photoreceptors.

  3. CNGA3 mutation is the most frequent cause of achromatopsia in this cohort of patients. Ten novel mutations were identified in CNGA3.

  4. Our results suggest that CNGA3 mutations are a common cause of cone-rod dystrophies and achromatopsia in the Chinese population.

  5. Genetic testing revealed a common homozygous mutation in CNGB3 (show CNGB3 Antibodies) in 5 patients with complete achromatopsia and heterozygous mutations in CNGA3 in 2 patients with incomplete achromatopsia.

  6. CNGA3 alternative splicing may have evolved, in part, to tune the interactions between cone CNG (show CNGA1 Antibodies) channels and membrane-bound phosphoinositides.

  7. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (show CNGB3 Antibodies) (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).

  8. The biochemical feedback regulation of CNGA3 mutations in color blindness is reported.

  9. These studies support a model in which intersubunit interactions control the sensitivity of cone CNG (show CNGA1 Antibodies) channels to regulation by phosphoinositides.

  10. in a set of consanguineous patient families with Leber congenital amaurosis study identified five putative disease-causing mutations, including four novel alleles, in six families; These five mutations are located in four genes, ALMS1 (show ALMS1 Antibodies), IQCB1 (show IQCB1 Antibodies), CNGA3, and MYO7A (show MYO7A Antibodies)

Mouse (Murine) Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. CNGA3 expression restored cone function in in CNGA3-/-/Nrl (show NRL Antibodies)-/- mice, an all-cone model of CNGA3 achromatopsia.

  2. cGMP/protein kinase (show CDK7 Antibodies) G signaling suppresses Itpr1 (show ITPR1 Antibodies) phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice.

  3. Homologous to the human disease, CNGA3 deficient mice reveal a loss of cone specific functionality leading to degeneration of affected cone photoreceptors. (review)

  4. This work investigated the functional modulation of cone CNG (show CNGA1 Antibodies) channel by exploring the channel-interacting proteins.

  5. The results of this study indicated that cGMP accumulation in photoreceptors can itself exert cytotoxic effect in cones, independently of CNG (show CNGA1 Antibodies) channel activity and Ca(2 (show CA2 Antibodies)+) influx.

  6. observed a nuclear translocation of apoptosis-inducing factor (AIF (show AIFM1 Antibodies)) and endonuclease G (show ENDOG Antibodies) in CNGA3(-/-)/Nrl (show NRL Antibodies)(-/-) and CNGB3 (show CNGB3 Antibodies)(-/-)/Nrl (show NRL Antibodies)(-/-) retinas, implying a mitochondrial insult in the endoplasmic reticulum stress-activated cell death process

  7. Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 (show EMILIN1 Antibodies) intracellular sequence that follows a predicted transmembrane domain in the C-terminus

  8. Cone CNG (show CNGA1 Antibodies) channel is a heterotetrameric complex likely at a stoichiometry of three CNGA3 and one CNGB3 (show CNGB3 Antibodies).

  9. This study provided evidence that CNGA3 contributes in an inhibitory manner to the central sensitization of pain pathways during inflammatory pain as a target of NO/cGMP signaling.

  10. The wild type and mutant CNGA3 were expressed in HEK293 cells, the channel's expression and cellular localization were examined by immunoblotting and immunofluorecences labeling, and activity of the channel was evaluated.

Cow (Bovine) Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. the S4 structural motif of CNGA3 is important for cellular processing of cone photoreceptor cyclic GMP (show NT5C2 Antibodies)-gated ion channels

Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) Antigen Profile

Protein Summary

This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with CNGA3

  • cyclic nucleotide gated channel alpha 3 (CNGA3) antibody
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 3 (HCN3) antibody
  • cyclic nucleotide gated channel alpha 3 (LOC100222773) antibody
  • cyclic nucleotide gated channel alpha 1 (CNGA1) antibody
  • cyclic nucleotide gated channel alpha 3 (Cnga3) antibody
  • ACHM2 antibody
  • CCNC1 antibody
  • CCNCa antibody
  • CCNCalpha antibody
  • CNCG3 antibody
  • CNG3 antibody
  • CNGA3 antibody
  • HCN3 antibody

Protein level used designations for CNGA3

cyclic nucleotide-gated channel cone photoreceptor subunit alpha , CNG1 , CNG-1 , CNG channel 1 , alpha subunit of cone photoreceptor CNG-channel , cyclic nucleotide gated channel alpha 3 , hyperpolarization activated cyclic nucleotide-gated potassium channel 3 , hyperpolarization-activated cation channel 3 , cyclic nucleotide gated channel alpha 3 protein , cyclic nucleotide-gated cation channel alpha-3-like , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like , CNG channel 3 , CNG-3 , CNG3 , alpha subunit of rod photoreceptor CNG-channel , cyclic nucleotide-gated channel rod photoreceptor subunit alpha , CNG channel alpha-3 , cone photoreceptor cGMP-gated channel alpha subunit , cone photoreceptor cGMP-gated channel subunit alpha , cyclic nucleotide-gated cation channel alpha-3 , cyclic nucleotide-gated channel alpha-3

GENE ID SPECIES
396144 Gallus gallus
470517 Pan troglodytes
707872 Macaca mulatta
717719 Macaca mulatta
100008730 Oryctolagus cuniculus
100233164 Ovis aries
100394541 Callithrix jacchus
100401204 Callithrix jacchus
100434768 Pongo abelii
100222773 Taeniopygia guttata
396143 Gallus gallus
1261 Homo sapiens
12790 Mus musculus
85257 Rattus norvegicus
281701 Bos taurus
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