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Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) ELISA Kits

CNGA3 encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Additionally we are shipping Cyclic Nucleotide Gated Channel alpha 3 Antibodies (33) and Cyclic Nucleotide Gated Channel alpha 3 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human CNGA3 CNGA3 1261 Q16281
Anti-Mouse CNGA3 CNGA3 12790 Q9JJZ8
Anti-Rat CNGA3 CNGA3 85257  
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More ELISA Kits for Cyclic Nucleotide Gated Channel alpha 3 Interaction Partners

Human Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. The c.955T>C change identified in large consanguineous Pakistani family represents the first variant of CNGA3 which was found to be responsible for the cone-rod dystrophy phenotype.

  2. Among Israeli and Palestinian patients, CNGA3 mutations are the leading cause of achromatopsia. Retinal structural results support the candidacy of CNGA3 ACHM for clinical trials for therapy of cone photoreceptors.

  3. CNGA3 mutation is the most frequent cause of achromatopsia in this cohort of patients. Ten novel mutations were identified in CNGA3.

  4. Our results suggest that CNGA3 mutations are a common cause of cone-rod dystrophies and achromatopsia in the Chinese population.

  5. Genetic testing revealed a common homozygous mutation in CNGB3 (show CNGB3 ELISA Kits) in 5 patients with complete achromatopsia and heterozygous mutations in CNGA3 in 2 patients with incomplete achromatopsia.

  6. CNGA3 alternative splicing may have evolved, in part, to tune the interactions between cone CNG (show CNGA1 ELISA Kits) channels and membrane-bound phosphoinositides.

  7. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (show CNGB3 ELISA Kits) (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).

  8. The biochemical feedback regulation of CNGA3 mutations in color blindness is reported.

  9. These studies support a model in which intersubunit interactions control the sensitivity of cone CNG (show CNGA1 ELISA Kits) channels to regulation by phosphoinositides.

  10. in a set of consanguineous patient families with Leber congenital amaurosis study identified five putative disease-causing mutations, including four novel alleles, in six families; These five mutations are located in four genes, ALMS1 (show ALMS1 ELISA Kits), IQCB1 (show IQCB1 ELISA Kits), CNGA3, and MYO7A (show MYO7A ELISA Kits)

Mouse (Murine) Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. CNGA3 expression restored cone function in in CNGA3-/-/Nrl (show NRL ELISA Kits)-/- mice, an all-cone model of CNGA3 achromatopsia.

  2. cGMP/protein kinase (show CDK7 ELISA Kits) G signaling suppresses Itpr1 (show ITPR1 ELISA Kits) phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice.

  3. Homologous to the human disease, CNGA3 deficient mice reveal a loss of cone specific functionality leading to degeneration of affected cone photoreceptors. (review)

  4. This work investigated the functional modulation of cone CNG (show CNGA1 ELISA Kits) channel by exploring the channel-interacting proteins.

  5. The results of this study indicated that cGMP accumulation in photoreceptors can itself exert cytotoxic effect in cones, independently of CNG (show CNGA1 ELISA Kits) channel activity and Ca(2 (show CA2 ELISA Kits)+) influx.

  6. observed a nuclear translocation of apoptosis-inducing factor (AIF (show AIFM1 ELISA Kits)) and endonuclease G (show ENDOG ELISA Kits) in CNGA3(-/-)/Nrl (show NRL ELISA Kits)(-/-) and CNGB3 (show CNGB3 ELISA Kits)(-/-)/Nrl (show NRL ELISA Kits)(-/-) retinas, implying a mitochondrial insult in the endoplasmic reticulum stress-activated cell death process

  7. Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 (show EMILIN1 ELISA Kits) intracellular sequence that follows a predicted transmembrane domain in the C-terminus

  8. Cone CNG (show CNGA1 ELISA Kits) channel is a heterotetrameric complex likely at a stoichiometry of three CNGA3 and one CNGB3 (show CNGB3 ELISA Kits).

  9. This study provided evidence that CNGA3 contributes in an inhibitory manner to the central sensitization of pain pathways during inflammatory pain as a target of NO/cGMP signaling.

  10. The wild type and mutant CNGA3 were expressed in HEK293 cells, the channel's expression and cellular localization were examined by immunoblotting and immunofluorecences labeling, and activity of the channel was evaluated.

Cow (Bovine) Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. the S4 structural motif of CNGA3 is important for cellular processing of cone photoreceptor cyclic GMP (show NT5C2 ELISA Kits)-gated ion channels

Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) Antigen Profile

Antigen Summary

This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with CNGA3

  • cyclic nucleotide gated channel alpha 3 (CNGA3) antibody
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 3 (HCN3) antibody
  • cyclic nucleotide gated channel alpha 3 (LOC100222773) antibody
  • cyclic nucleotide gated channel alpha 1 (CNGA1) antibody
  • cyclic nucleotide gated channel alpha 3 (Cnga3) antibody
  • ACHM2 antibody
  • CCNC1 antibody
  • CCNCa antibody
  • CCNCalpha antibody
  • CNCG3 antibody
  • CNG3 antibody
  • CNGA3 antibody
  • HCN3 antibody

Protein level used designations for CNGA3

cyclic nucleotide-gated channel cone photoreceptor subunit alpha , CNG1 , CNG-1 , CNG channel 1 , alpha subunit of cone photoreceptor CNG-channel , cyclic nucleotide gated channel alpha 3 , hyperpolarization activated cyclic nucleotide-gated potassium channel 3 , hyperpolarization-activated cation channel 3 , cyclic nucleotide gated channel alpha 3 protein , cyclic nucleotide-gated cation channel alpha-3-like , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like , CNG channel 3 , CNG-3 , CNG3 , alpha subunit of rod photoreceptor CNG-channel , cyclic nucleotide-gated channel rod photoreceptor subunit alpha , CNG channel alpha-3 , cone photoreceptor cGMP-gated channel alpha subunit , cone photoreceptor cGMP-gated channel subunit alpha , cyclic nucleotide-gated cation channel alpha-3 , cyclic nucleotide-gated channel alpha-3

GENE ID SPECIES
396144 Gallus gallus
470517 Pan troglodytes
707872 Macaca mulatta
717719 Macaca mulatta
100008730 Oryctolagus cuniculus
100233164 Ovis aries
100394541 Callithrix jacchus
100401204 Callithrix jacchus
100434768 Pongo abelii
100222773 Taeniopygia guttata
396143 Gallus gallus
1261 Homo sapiens
12790 Mus musculus
85257 Rattus norvegicus
281701 Bos taurus
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