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Cyclic Nucleotide Gated Channel alpha 3 Proteins (CNGA3)

CNGA3 encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Additionally we are shipping Cyclic Nucleotide Gated Channel alpha 3 Antibodies (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNGA3 1261 Q16281
CNGA3 12790 Q9JJZ8
Rat CNGA3 CNGA3 85257  
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Top Cyclic Nucleotide Gated Channel alpha 3 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CNGA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) Interaction Partners

Human Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. The c.955T>C change identified in large consanguineous Pakistani family represents the first variant of CNGA3 which was found to be responsible for the cone-rod dystrophy phenotype.

  2. Among Israeli and Palestinian patients, CNGA3 mutations are the leading cause of achromatopsia. Retinal structural results support the candidacy of CNGA3 ACHM for clinical trials for therapy of cone photoreceptors.

  3. CNGA3 mutation is the most frequent cause of achromatopsia in this cohort of patients. Ten novel mutations were identified in CNGA3.

  4. Our results suggest that CNGA3 mutations are a common cause of cone-rod dystrophies and achromatopsia in the Chinese population.

  5. Genetic testing revealed a common homozygous mutation in CNGB3 (show CNGB3 Proteins) in 5 patients with complete achromatopsia and heterozygous mutations in CNGA3 in 2 patients with incomplete achromatopsia.

  6. CNGA3 alternative splicing may have evolved, in part, to tune the interactions between cone CNG (show CNGA1 Proteins) channels and membrane-bound phosphoinositides.

  7. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (show CNGB3 Proteins) (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).

  8. The biochemical feedback regulation of CNGA3 mutations in color blindness is reported.

  9. These studies support a model in which intersubunit interactions control the sensitivity of cone CNG (show CNGA1 Proteins) channels to regulation by phosphoinositides.

  10. in a set of consanguineous patient families with Leber congenital amaurosis study identified five putative disease-causing mutations, including four novel alleles, in six families; These five mutations are located in four genes, ALMS1, IQCB1, CNGA3, and MYO7A

Mouse (Murine) Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. CNGA3 expression restored cone function in in CNGA3-/-/Nrl (show NRL Proteins)-/- mice, an all-cone model of CNGA3 achromatopsia.

  2. cGMP/protein kinase (show CDK7 Proteins) G signaling suppresses Itpr1 (show ITPR1 Proteins) phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice.

  3. Homologous to the human disease, CNGA3 deficient mice reveal a loss of cone specific functionality leading to degeneration of affected cone photoreceptors. (review)

  4. This work investigated the functional modulation of cone CNG (show CNGA1 Proteins) channel by exploring the channel-interacting proteins.

  5. The results of this study indicated that cGMP accumulation in photoreceptors can itself exert cytotoxic effect in cones, independently of CNG (show CNGA1 Proteins) channel activity and Ca(2 (show CA2 Proteins)+) influx.

  6. observed a nuclear translocation of apoptosis-inducing factor (AIF (show AIFM1 Proteins)) and endonuclease G (show ENDOG Proteins) in CNGA3(-/-)/Nrl (show NRL Proteins)(-/-) and CNGB3 (show CNGB3 Proteins)(-/-)/Nrl (show NRL Proteins)(-/-) retinas, implying a mitochondrial insult in the endoplasmic reticulum stress-activated cell death process

  7. Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 (show EMILIN1 Proteins) intracellular sequence that follows a predicted transmembrane domain in the C-terminus

  8. Cone CNG (show CNGA1 Proteins) channel is a heterotetrameric complex likely at a stoichiometry of three CNGA3 and one CNGB3 (show CNGB3 Proteins).

  9. This study provided evidence that CNGA3 contributes in an inhibitory manner to the central sensitization of pain pathways during inflammatory pain as a target of NO/cGMP signaling.

  10. The wild type and mutant CNGA3 were expressed in HEK293 cells, the channel's expression and cellular localization were examined by immunoblotting and immunofluorecences labeling, and activity of the channel was evaluated.

Cow (Bovine) Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) interaction partners

  1. the S4 structural motif of CNGA3 is important for cellular processing of cone photoreceptor cyclic GMP (show NT5C2 Proteins)-gated ion channels

Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) Protein Profile

Protein Summary

This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with CNGA3

  • cyclic nucleotide gated channel alpha 3 (CNGA3)
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 3 (HCN3)
  • cyclic nucleotide gated channel alpha 3 (LOC100222773)
  • cyclic nucleotide gated channel alpha 1 (CNGA1)
  • cyclic nucleotide gated channel alpha 3 (Cnga3)
  • ACHM2 protein
  • CCNC1 protein
  • CCNCa protein
  • CCNCalpha protein
  • CNCG3 protein
  • CNG3 protein
  • CNGA3 protein
  • HCN3 protein

Protein level used designations for CNGA3

cyclic nucleotide-gated channel cone photoreceptor subunit alpha , CNG1 , CNG-1 , CNG channel 1 , alpha subunit of cone photoreceptor CNG-channel , cyclic nucleotide gated channel alpha 3 , hyperpolarization activated cyclic nucleotide-gated potassium channel 3 , hyperpolarization-activated cation channel 3 , cyclic nucleotide gated channel alpha 3 protein , cyclic nucleotide-gated cation channel alpha-3-like , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like , CNG channel 3 , CNG-3 , CNG3 , alpha subunit of rod photoreceptor CNG-channel , cyclic nucleotide-gated channel rod photoreceptor subunit alpha , CNG channel alpha-3 , cone photoreceptor cGMP-gated channel alpha subunit , cone photoreceptor cGMP-gated channel subunit alpha , cyclic nucleotide-gated cation channel alpha-3 , cyclic nucleotide-gated channel alpha-3

GENE ID SPECIES
396144 Gallus gallus
470517 Pan troglodytes
707872 Macaca mulatta
717719 Macaca mulatta
100008730 Oryctolagus cuniculus
100233164 Ovis aries
100394541 Callithrix jacchus
100401204 Callithrix jacchus
100434768 Pongo abelii
100222773 Taeniopygia guttata
396143 Gallus gallus
1261 Homo sapiens
12790 Mus musculus
85257 Rattus norvegicus
281701 Bos taurus
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