Cyclin F Proteins (CCNF)

CCNF encodes a member of the cyclin family. Additionally we are shipping Cyclin F Antibodies (61) and Cyclin F Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCNF 899 P41002
CCNF 12449 P51944
CCNF 117524 Q8K4F8
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Top Cyclin F Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

CCNF Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Cyclin F (CCNF) Interaction Partners

Human Cyclin F (CCNF) interaction partners

  1. cyclin F is a novel F-box protein that functions as an intrinsic cellular regulator of HIV-1 Vif (show BTG1 Proteins) and has a negative regulatory effect on the maintenance of viral infectivity by restoring APOBEC3G (show APOBEC3G Proteins) expression

  2. The SCYL1- BP1 (show GORAB Proteins) affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 (show RRM2 Proteins) proteins, thus constituting a dual regulatory circuit.

  3. Data indicate that a missense mutation in cyclin F (CCNF) in a large Amyotrophic lateral sclerosis (ALS (show IGFALS Proteins)) and frontotemporal dementia (FTD (show FTL Proteins)) family.

  4. CDC6 (show CDC6 Proteins) and Cyclin F interact through defined sequence motifs that promote CDC6 (show CDC6 Proteins) ubiquitylation and degradation.

  5. Cyclin F suppresses B-Myb (show MYBL2 Proteins) activity to promote cell cycle checkpoint control.

  6. Cyclin F controls genome stability through ubiquitin-mediated proteolysis. (Review)

  7. After DNA damage, cyclin F is downregulated in an ATR (show ANTXR1 Proteins)-dependent manner to allow accumulation of RRM2 (show RRM2 Proteins). Defective elimination of cyclin F delays DNA repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a nondegradable RRM2 (show RRM2 Proteins) mutant.

  8. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity

Mouse (Murine) Cyclin F (CCNF) interaction partners

  1. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity

  2. CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac (show ADCY10 Proteins) and chorioallantoic placentation, die around embryonic day 10.5.

Cyclin F (CCNF) Protein Profile

Protein Summary

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.

Gene names and symbols associated with Cyclin F Proteins (CCNF)

  • cyclin-F-like (LOC100068378)
  • cyclin F (ccnf)
  • cyclin F (CCNF)
  • cyclin F (LOC100230213)
  • cyclin F (Ccnf)
  • cyclin-F-like (LOC100518243)
  • cb443 protein
  • CycF protein
  • Cyclin-F protein
  • DKFZp459P0432 protein
  • FBX1 protein
  • Fbxo1 protein
  • zgc:77240 protein

Protein level used designations for Cyclin F Proteins (CCNF)

cyclin-F , cyclin F , G2/mitotic-specific cyclin-F , G2/mitotic-specific cyclin-F-like , g2/mitotic-specific cyclin-F-like , F-box only protein 1

100068378 Equus caballus
379591 Xenopus laevis
453835 Pan troglodytes
496496 Xenopus (Silurana) tropicalis
696745 Macaca mulatta
100013582 Monodelphis domestica
100172228 Pongo abelii
100230213 Taeniopygia guttata
100386337 Callithrix jacchus
100472291 Ailuropoda melanoleuca
100346680 Oryctolagus cuniculus
100580954 Nomascus leucogenys
899 Homo sapiens
416749 Gallus gallus
610890 Canis lupus familiaris
505200 Bos taurus
12449 Mus musculus
117524 Rattus norvegicus
266981 Danio rerio
100518243 Sus scrofa
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