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Cyclin K Proteins (CCNK)

The protein encoded by CCNK is a member of the transcription cyclin family. Additionally we are shipping Cyclin K Antibodies (40) and Cyclin K Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCNK 8812 O75909
CCNK 12454  
Rat CCNK CCNK 500715  
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Top Cyclin K Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CCNK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

More Proteins for Cyclin K (CCNK) Interaction Partners

Human Cyclin K (CCNK) interaction partners

  1. Structures of CDK12 (show CRKRS Proteins)/CycK complexes solved in the presence of AMP (show APRT Proteins)-PNP (show NP Proteins).

  2. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12 (show CRKRS Proteins))/cyclin K (CycK) complex, rendering the kinase inactive.

  3. Cyclin K is highly expressed in mammalian testes in a developmentally regulated manner.

  4. Cyclin K interacts with CDK12 and CDK13 but not CDK9 in cells, and is required to maintain self-renewal in ES cells.

  5. Cyclin (show PCNA Proteins) K1 is the primary cyclin (show PCNA Proteins) partner for CDK12/CrkRS (show CRKRS Proteins) and it is required for activation of CDK12/CrkRS (show CRKRS Proteins) to phosphorylate the C-terminal domain of RNA Pol II.

  6. Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9 (show CDK9 Proteins))-cyclin T1 (show CCNT1 Proteins) interaction in Nef-dependent manner.

  7. These results reveal an unexpectedly direct role for CDK9 (show CDK9 Proteins)-cyclin K in checkpoint pathways that maintain genome integrity in response to replication stress.

  8. Cyclin K-expressing multiple myeloma LP-1 (show RPLP1 Proteins) cells have lost their migration properties and display enhanced clonogenic capacities

  9. P-TEFb (show CCNT1 Proteins) containing cyclin K and Cdk9 (show CDK9 Proteins) can activate transcription via RNA.

  10. cyclin K may play a role in regulating the cell cycle or apoptosis

Mouse (Murine) Cyclin K (CCNK) interaction partners

  1. that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.

  2. Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

Cyclin K (CCNK) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.

Gene names and symbols associated with Cyclin K Proteins (CCNK)

  • Cyclin K (CycK)
  • cyclin K (ccnk)
  • cyclin k (AaeL_AAEL013531)
  • cyclin K (CCNK)
  • cyclin K (Ccnk)
  • cyclin K (LOC100345846)
  • AW123198 protein
  • AW413594 protein
  • CG15218 protein
  • CPR4 protein
  • CycK protein
  • cyclin-K protein
  • Dmel\\CG15218 protein
  • fe49g08 protein
  • MGC115029 protein
  • MGC145994 protein
  • si:dkey-60a16.2 protein
  • wu:fe49g08 protein
  • zgc:158372 protein

Protein level used designations for Cyclin K Proteins (CCNK)

CG15218-PA , CG15218-PB , CycK-PA , CycK-PB , CyclinK , cyclin K , cyclin k , cyclin-K

49816 Drosophila melanogaster
569432 Danio rerio
734423 Xenopus laevis
779776 Xenopus (Silurana) tropicalis
5578158 Aedes aegypti
100018485 Monodelphis domestica
8812 Homo sapiens
12454 Mus musculus
423446 Gallus gallus
612481 Canis lupus familiaris
100157799 Sus scrofa
530744 Bos taurus
500715 Rattus norvegicus
100345846 Oryctolagus cuniculus
101117113 Ovis aries
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