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CNNM2 encodes a member of the ancient conserved domain containing protein family. Additionally we are shipping Cyclin M2 Antibodies (45) and many more products for this protein.
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The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form.
Cells expressing mutated CNNM2 proteins did not show increased Mg(2 (show MUC7 Proteins)+) uptake.
This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition.
Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri.
crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation
analysis of structure of CNNM2 and its post-translational modifications
ACDP2 splice-variant 1 is a functional Mg2 (show MUC7 Proteins)+-transporting entity per se.
The CNNM2 locus is associated with serum Mg(2 (show MUC7 Proteins)+) concentrations.
ACDP2 may provide a regulated transporter for Mg2 (show MCOLN1 Proteins)+ and other divalent cations in epithelial ce
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, metal transporter CNNM4
, ancient conserved domain-containing protein 4
, ancient conserved domain-containing protein 2
, metal transporter CNNM2
, ancient conserved domain protein 2
, cyclin-like protein 2