Cyclin M2 Proteins (CNNM2)

CNNM2 encodes a member of the ancient conserved domain containing protein family. Additionally we are shipping Cyclin M2 Antibodies (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNNM2 54805 Q9H8M5
CNNM2 94219 Q3TWN3
Rat CNNM2 CNNM2 294014 Q5U2P1
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Top Cyclin M2 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days

CNNM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

More Proteins for Cyclin M2 (CNNM2) Interaction Partners

Human Cyclin M2 (CNNM2) interaction partners

  1. this study implicates altered neural expression of BORCS7, AS3MT (show AS3MT Proteins), and NT5C2 (show NT5C2 Proteins) in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  2. Sensitivity of CNNM2 expression to extracellular Mg(2 (show MUC7 Proteins)+) depletion depends on cell type.

  3. The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form.

  4. Cells expressing mutated CNNM2 proteins did not show increased Mg(2 (show MUC7 Proteins)+) uptake.

  5. This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition.

  6. Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri.

  7. crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation

  8. analysis of structure of CNNM2 and its post-translational modifications

  9. ACDP2 splice-variant 1 is a functional Mg2 (show MUC7 Proteins)+-transporting entity per se.

  10. The CNNM2 locus is associated with serum Mg(2 (show MUC7 Proteins)+) concentrations.

Mouse (Murine) Cyclin M2 (CNNM2) interaction partners

  1. we generated kidney-specific Cnnm2- deficient mice and clearly demonstrated that the CNNM2 function in the kidney is important in maintaining not only magnesium homeostasis but also blood pressure.

  2. data shed new light on the structural basis underlying the interaction between PRL (show PRL Proteins) phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1 (show PTP4A1 Proteins), upon binding to CNNM2, might increase the intracellular concentration of Mg(2 (show MCOLN1 Proteins)+) thereby contributing to tumor progression and metastasis.

  3. Thus, sperm motility and Ca(2 (show CA2 Proteins)+) response were more severely affected in sperm from Cnnm2(+/Delta); Cnnm4 (show CNNM4 Proteins)(Delta/Delta) mice than in those from Cnnm4 (show CNNM4 Proteins)(Delta/Delta) mice, implicating CNNM2 in regulating these processes.

  4. analysis of structure of CNNM2 and its post-translational modifications

  5. ACDP2 may provide a regulated transporter for Mg2 (show MCOLN1 Proteins)+ and other divalent cations in epithelial ce

Cyclin M2 (CNNM2) Protein Profile

Protein Summary

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Cyclin M2 Proteins (CNNM2)

  • cyclin M2 (CNNM2)
  • cyclin M2 (cnnm2)
  • cyclin M2 (Cnnm2)
  • Acdp2 protein
  • acdp4 protein
  • AU015877 protein
  • AW048635 protein
  • Clp2 protein
  • cnnm4 protein

Protein level used designations for Cyclin M2 Proteins (CNNM2)

cyclin M2 , metal transporter CNNM4 , cyclin-M4 , ancient conserved domain-containing protein 4 , ancient conserved domain-containing protein 2 , metal transporter CNNM2 , ancient conserved domain protein 2 , cyclin-M2 , cyclin-like protein 2 , mACDP2

428975 Gallus gallus
450705 Pan troglodytes
100022652 Monodelphis domestica
100036645 Xenopus (Silurana) tropicalis
100059801 Equus caballus
100081019 Ornithorhynchus anatinus
100347338 Oryctolagus cuniculus
100440124 Pongo abelii
100484329 Ailuropoda melanoleuca
100540642 Meleagris gallopavo
100554221 Anolis carolinensis
100598160 Nomascus leucogenys
54805 Homo sapiens
94219 Mus musculus
294014 Rattus norvegicus
486866 Canis lupus familiaris
100155831 Sus scrofa
504632 Bos taurus
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