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Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Additionally we are shipping CDK14 Proteins (12) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal CDK14 Primary Antibody for EIA, WB - ABIN954104
Shu, Lv, Qin, Ma, Wang, Peng, Luo, Xu, Sun, Wu: Functional characterization of human PFTK1 as a cyclin-dependent kinase. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 5 references for ABIN954104
Human Polyclonal CDK14 Primary Antibody for EIA, IHC (p) - ABIN359704
Yang, Chen: Identification and cellular localization of human PFTAIRE1. in Gene 2001
Show all 2 references for ABIN359704
Human Polyclonal CDK14 Primary Antibody for WB - ABIN1881191
Quina, Wang, Ng, Turner: Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 2 references for ABIN1881191
Human Polyclonal CDK14 Primary Antibody for ICC, IF - ABIN4345007
Miyagaki, Yamasaki, Miyata, Takahashi, Kurokawa, Nakajima, Takiguchi, Fujiwara, Ishii, Tanaka, Mori, Doki: Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma. in British journal of cancer 2012
Human Polyclonal CDK14 Primary Antibody for EIA, WB - ABIN453263
Denoeud, Kapranov, Ucla, Frankish, Castelo, Drenkow, Lagarde, Alioto, Manzano, Chrast, Dike, Wyss, Henrichsen, Holroyd, Dickson, Taylor, Hance, Foissac, Myers, Rogers, Hubbard, Harrow, Guigó et al.: Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. in Genome research 2007
The expression level of PFTK1 was correlated with tumor grade, FIGO stage, lymph node metastasis of EOC patients as well as poor prognosis.
Knockdown of PFTK1 inhibited the proliferation and invasion of pancreatic cancer cells as well as the EMT (show ITK Antibodies) progress by suppressing the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.
PFTK1 overexpression promoted proliferation, migration and invasion of gastric cancer cells, while PFTK1 knockdown led to the opposite results.
Knockdown of PFTK1 increases E-cadherin (show CDH1 Antibodies) expression, decreases vimentin (show VIM Antibodies) expression and inhibits migration of glioma cells.
Up-regulated PFTK1 might promote breast cancer progression.
Cigarette smoke down regulates CDK14 levels and impairs Wnt (show WNT2 Antibodies) signaling.
findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 (show MARK3 Antibodies) and PFTK1
binding of CCNY (show CCNY Antibodies) to 14-3-3 (show YWHAQ Antibodies) significantly enhanced the association between CCNY (show CCNY Antibodies) and CDK14
Human cyclin Y (CCNY (show CCNY Antibodies)) is a phosphoprotein in vivo and phosphorylation of CCNY (show CCNY Antibodies) by CDK14 triggers its ubiquitination and degradation.
in patients with oesophageal squamous cell carcinoma 5-year overall survival rate was poorer in patients positive for PFTK1 than those with negative expression; uni- and multivariate analyses identified PFTK1 as an independent marker of prognosis
may be a key regulator for thyrotropin-releasing hormone (TRH (show TRH Antibodies)) action in the cerebellum through the NO-cGMP pathway
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
PFTAIRE protein kinase 1
, cell division protein kinase 14
, serine/threonine-protein kinase PFTAIRE-1
, Cell division protein kinase 14