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Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Additionally we are shipping CDK14 Antibodies (77) and CDK14 Proteins (12) and many more products for this protein.
The expression level of PFTK1 was correlated with tumor grade, FIGO stage, lymph node metastasis of EOC patients as well as poor prognosis.
Knockdown of PFTK1 inhibited the proliferation and invasion of pancreatic cancer cells as well as the EMT (show ITK ELISA Kits) progress by suppressing the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway.
PFTK1 overexpression promoted proliferation, migration and invasion of gastric cancer cells, while PFTK1 knockdown led to the opposite results.
Knockdown of PFTK1 increases E-cadherin (show CDH1 ELISA Kits) expression, decreases vimentin (show VIM ELISA Kits) expression and inhibits migration of glioma cells.
Up-regulated PFTK1 might promote breast cancer progression.
Cigarette smoke down regulates CDK14 levels and impairs Wnt (show WNT2 ELISA Kits) signaling.
findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 (show MARK3 ELISA Kits) and PFTK1
binding of CCNY (show CCNY ELISA Kits) to 14-3-3 (show YWHAQ ELISA Kits) significantly enhanced the association between CCNY (show CCNY ELISA Kits) and CDK14
Human cyclin Y (CCNY (show CCNY ELISA Kits)) is a phosphoprotein in vivo and phosphorylation of CCNY (show CCNY ELISA Kits) by CDK14 triggers its ubiquitination and degradation.
in patients with oesophageal squamous cell carcinoma 5-year overall survival rate was poorer in patients positive for PFTK1 than those with negative expression; uni- and multivariate analyses identified PFTK1 as an independent marker of prognosis
may be a key regulator for thyrotropin-releasing hormone (TRH (show TRH ELISA Kits)) action in the cerebellum through the NO-cGMP pathway
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
PFTAIRE protein kinase 1
, cell division protein kinase 14
, serine/threonine-protein kinase PFTAIRE-1
, Cell division protein kinase 14