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The protein encoded by CDK2AP1 is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Additionally we are shipping Cyclin-Dependent Kinase 2 Associated Protein 1 Antibodies (45) and Cyclin-Dependent Kinase 2 Associated Protein 1 Kits (2) and many more products for this protein.
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Human CDK2AP1 Protein expressed in Escherichia coli (E. coli) - ABIN666944
Hu, Hu, Kim, Tsuji, McBride, Hinds, Wong: Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression. in Cancer research 2004
Show all 2 references for ABIN666944
Cdk2ap1 expression is primarily regulated by progesterone and the progesterone receptor (show PGR Proteins) in uterus and is mainly localized to proliferating tissues.
Results indicate that DOC-1 (show CA6 Proteins) is a bona fide subunit of the Mi-2 (show CHD4 Proteins)/NuRD chromatin remodeling complex.
(CDK2 (show CDK2 Proteins)-AP1 (show JUN Proteins)) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin.
p12CDK2-AP1 (show JUN Proteins) forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12
Results suggest that overexpression of CDK2 (show CDK2 Proteins)-associating protein 1 (p12CDK2AP1) leads to testicular and ovarian abnormalities, a phenotype closely related to that of cdk2 (show CDK2 Proteins)-/- mice.
Cdk2ap1, a negative regulator of Cdk2 (show CDK2 Proteins) function and cell cycle, promotes Oct4 (show POU5F1 Proteins) promoter methylation during murine embryonic stem cell differentiation to down-regulate Oct4 (show POU5F1 Proteins) expression.
Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis.
CDK2AP1-mediated differentiation of murine embryonic stem cell was elicited through the regulation of pRb (show PGR Proteins).
knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 (show TP53 Proteins) dependent
In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 (show CDK2 Proteins) transcript and protein.
Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis
CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells.
Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma.
Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region
In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 (show S100A7 Proteins) was upregulated in all oral lesions.
P12(CDK2AP1) is downregulated by miR (show MLXIP Proteins)-21
Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity.
Data support the role of cdk2ap1 as a tumor suppressor gene that can regulate squamous cell carcinoma growth in a cell autonomous manner through decreases in invasiveness and a non-cell autonomous manner through decreases in angiogenesis phenotypes.
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
cyclin-dependent kinase 2 associated protein 1
, CDK2-associated protein 1
, CDK2 (cyclin-dependent kinase 2)-associated protein 1
, cyclin-dependent kinase 2-associated protein 1
, CDK2-associated protein1
, deleted in oral cancer 1
, putative oral cancer suppressor
, Deleted in oral cancer-1