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The protein encoded by CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. Additionally we are shipping CDK5R1 Proteins (15) and CDK5R1 Kits (7) and many more products for this protein.
Showing 10 out of 98 products:
Chicken Monoclonal CDK5R1 Primary Antibody for ICC, IF - ABIN361805
Shimamura, Perera, Foley, Sang, Rodig, Inoue, Chen, Li, Carretero, Li, Sinha, Carey, Borgman, Jimenez, Meyerson, Ying, Barsoum, Wong, Shapiro: Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Show all 9 references for ABIN361805
Mouse (Murine) Monoclonal CDK5R1 Primary Antibody for IF, WB - ABIN968820
Forsythe, Jarvis, Turner, Elmore, Holt: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. in The Journal of biological chemistry 2001
Show all 4 references for ABIN968820
Chicken Monoclonal CDK5R1 Primary Antibody for ICC, IF - ABIN2486466
Nair, Toran, Rimerman, Hjermstad, Smithgall, Smith: A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. in Cell stress & chaperones 1997
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Chicken Monoclonal CDK5R1 Primary Antibody for ICC, IF - ABIN2486467
Hu, Toft, Anselmo, Wang: In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins. in Journal of virology 2001
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Human Polyclonal CDK5R1 Primary Antibody for IF, ELISA - ABIN1533901
Tsai, Delalle, Caviness, Chae, Harlow: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. in Nature 1994
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p35 likely acts downstream of egr1 (show EGR1 Antibodies) to control the differentiation of Parvalbumin (show PVALB Antibodies)+ amacrine cells.
CDK5 (show CDK5 Antibodies) mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 was observed in both cerebral cortex and cerebellum at two months of age
Under cell-free in vitro conditions, p35 (show ANXA1 Antibodies) is covalently modified by SUMO1 (show SUMO1 Antibodies). SUMO2 (show SUMO2 Antibodies) is conjugated to p35 (show ANXA1 Antibodies) in cells. The 2 major SUMO acceptor lysines in p35 (show ANXA1 Antibodies) are K246 and K290. Different degrees of oxidative stress resulted in differential p35 (show ANXA1 Antibodies) sumoylation.
Cdk5 (show CDK5 Antibodies)/p35 (show ANXA1 Antibodies) is required for motor learning and involved in long-term synaptic plasticity.
Expression of p35 (show ANXA1 Antibodies) is upregulated in human pituitary adenomas.
These results reveal a physiological role of p25 (show LCN2 Antibodies) production in synaptic plasticity and memory and provide new insights into the function of p25 (show LCN2 Antibodies) in Abeta (show APP Antibodies)-associated neurotoxicity and Alzheimer's disease-like pathology.
Structural basis for the different stability and activity between the Cdk5 (show CDK5 Antibodies) complexes with p35 (show ANXA1 Antibodies) and p39 (show JUN Antibodies) activators.
Reduced p35 (show ANXA1 Antibodies) basal content and down--regulation of CDK5 (show CDK5 Antibodies)/p35/p25 by antipsychotics are demonstrated in postmortem prefrontal cortex of schizophrenic subjects.
The present study dissects the role of 3 single nucleotide polymorphisms (rs334558 and rs6438552 of GSK3B (show GSK3b Antibodies), and rs735555 of CDK5R1) in Parkinson's disease pathogenesis among eastern Indians.
p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity.
The decrease in membrane-associated p35 (show ANXA1 Antibodies) in socially isolated transgenic mice reduces associated levels of p35 (show ANXA1 Antibodies), alpha-CaMKII, and GluR1 (show GRIA1 Antibodies) and leads to endocytosis of AMPA (show GRIA3 Antibodies) receptors.
CDK5 (show CDK5 Antibodies)/p35 (show ANXA1 Antibodies) may represent a biomarker for prognosis in patients with non-small cell lung cancer
The transiently active CDK5 (show CDK5 Antibodies)-p35 complexes limited the LPS (show TLR4 Antibodies)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (show SOCS3 Antibodies))
Cdk5 (cyclin-dependent kinase 5 (show CDK5 Antibodies)) requires p35 regulatory subunit (Cdk5r1) for activation; data suggest Cdk5r1 stability regulates Cdk5 (show CDK5 Antibodies) activity in neurons; Cdk5r1 is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.
These data suggest p35 and p39 (show ATP6V0D1 Antibodies) have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 (show CDK5 Antibodies) activation.
Studied the effect of reduced levels of p25 and p35, two proteins required for cdk5 (show CDK5 Antibodies) activation, on striatal neurodegeneration using mice with targeted deletion of p35.
p35 interacts with NIF-1 (show ZNF335 Antibodies) and regulates the subcellular localization of the protein independent of Cdk5 (show CDK5 Antibodies)-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5 (show CDK5 Antibodies)
Cdk5 (show CDK5 Antibodies)/p35 regulates spatial learning and memory.
Our findings suggest that p35/Rac1 signaling is critical in the CDK5 (show CDK5 Antibodies) silencing-induced neuroprotection against glutamate (show GRIN1 Antibodies) neurotoxicity
provide a mechanistic explanation that Sig-1Rs help maintain proper tau phosphorylation by potentially carrying and providing myristic acid to p35 for enhanced p35 degradation to circumvent the formation of overreactive cdk5/p25
This report shows that herpes simplex virus 1 increases p35 levels, changes the primary localization of CDK-5 (show CDK5 Antibodies) from the nucleus to the cytoplasm, and enhances CDK-5 (show CDK5 Antibodies) activity during lytic or acute infection.
the effects of p25, although normally attributed to activate CDK5 (show CDK5 Antibodies), may be mediated in part by elevated GSK3beta (show GSK3b Antibodies) activity.
Data suggest that up-regulation of S100A8 (show S100A8 Antibodies) and S100A9 (show S100A9 Antibodies) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
, cyclin-dependent kinase 5 regulatory subunit
, cyclin-dependent kinase 5 activator 1
, cyclin-dependent kinase 5 regulatory subunit 1
, CDK5 activator 1
, TPKII regulatory subunit
, neuronal CDK5 activator
, regulatory partner for CDK5 kinase
, tau protein kinase II 23kDa subunit
, cyclin-dependent kinase 5, regulatory subunit (p35) 1
, tau protein kinase II 23 kDa subunit
, Harvey rat sarcoma oncogene, subgroup R
, Harvey rat sarcoma virus oncogene, subgroup R
, Ras-related protein R-RAS (P23)
, ras-related protein R-Ras
, S100 calcium-binding protein A9
, neutrophil cytosolic 23 kDa protein
, protein S100-A9
, 21 kDa transmembrane-trafficking protein
, p24 family protein delta-1
, transmembrane emp24 domain-containing protein 10
, transmembrane protein Tmp21
, transmembrane trafficking protein
, growth-related translationally controlled tumor protein
, growth-related translationally-controlled tumor protein
, translationally-controlled tumor protein homolog