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The protein encoded by CDKN3 belongs to the dual specificity protein phosphatase family. Additionally we are shipping CDKN3 Antibodies (111) and CDKN3 Kits (16) and many more products for this protein.
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the mechanism of CDKN3 overexpression in human cancer
CDKN3 is frequently upregulated in gastric cancer tissues and cell lines and is related to advanced clinical stage, recurrence, and poor clinical outcome in gastric cancer. The functional data strongly suggest that CDKN3 behaves as an oncogene (show RAB1A Proteins) in gastric cancer, and downregulation of CDKN3 could inhibit gastric cancer cell proliferation, migration, and invasion, and induce cell cycle arrest and apoptosis.
CDKN3 may act as a tumor suppressor in liver tissues by modulation of the cell survival signal transduction, monitoring carcinogenesis and elimination of abnormal cells.
These results suggest that CDKN3 acts as an oncogene (show RAB1A Proteins) during breast cancer progression. The in vitro silencing of CDKN3 promoted apoptosis, induced G1 phase cell cycle arrest and inhibited cell migration.
Knockdown of Cdkn3 stabilizes Mps1 (show IDUA Proteins) at centrosomes.
CDKN3 mRNA may be a good survival biomarker and potential therapeutic target in cervical cancer
CDKN3 overexpression in lung adenocarcinoma is not attributed to alternative splicing or mutation but is likely due to increased mitotic activity, arguing against CDKN3 as a tumour suppressor
CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer cells.
These results highlight the importance of CDKN3 in Bcr-Abl (show ABL1 Proteins)-mediated leukemogenesis.
High CDKN3 expression is associated with colorectal cancer.
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cyclin-dependent kinase inhibitor 3
, cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
, CDK2-associated dual specificity phosphatase
, CDK2-associated dual-specificity phosphatase
, Cdk-associated protein phosphatase
, cyclin-dependent kinase interacting protein 2
, cyclin-dependent kinase interactor 1
, cyclin-dependent kinase-interacting protein 2
, kinase associated phosphatase
, kinase-associated phosphatase
, Kinase-associated phosphatase