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anti-Cyclin-Dependent Kinase-Like 5 (CDKL5) Antibodies

CDKL5 is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Additionally we are shipping CDKL5 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CDKL5 6792 O76039
CDKL5 382253 Q3UTQ8
CDKL5 100362725  
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Top anti-CDKL5 Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with STK9 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The anti-STK9 Pab is used in Western blot to detect STK9 in mouse lung tissue lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-STK9 Pab (ABIN391362) is used in Western blot to detect STK9 in mouse lung tissue lysate. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with STK9 Antibody (C-term) (ABIN391362), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CDKL5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate WB Suggested Anti-CDKL5  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control:.21_B cell lysate  CDKL5 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB Western blot analysis of CDKL5 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Mouse Rabbit Un-conjugated WB Mouse Cdkl5 Antibody (C-term)  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Cdkl5 antibody detected the Cdkl5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Mouse Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$383.17
Details

CDKL5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CDKL5 Antibodies

  1. Human Polyclonal CDKL5 Primary Antibody for WB - ABIN611314 : Barbara, Wrana, Letarte: Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. in The Journal of biological chemistry 1999 (PubMed)
    Show all 4 references for ABIN611314

  2. Human Polyclonal CDKL5 Primary Antibody for EIA, IHC (p) - ABIN359452 : Kalscheuer, Tao, Donnelly, Hollway, Schwinger, Kübart, Menzel, Hoeltzenbein, Tommerup, Eyre, Harbord, Haan, Sutherland, Ropers, Gécz: Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation. in American journal of human genetics 2003 (PubMed)
    Show all 2 references for ABIN359452

  3. Human Polyclonal CDKL5 Primary Antibody for IHC (p), WB - ABIN391362 : Montini, Andolfi, Caruso, Buchner, Walpole, Mariani, Consalez, Trump, Ballabio, Franco: Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region. in Genomics 1998 (PubMed)

More Antibodies against CDKL5 Interaction Partners

Human Cyclin-Dependent Kinase-Like 5 (CDKL5) interaction partners

  1. Mutations in exon 8 of cyclin-dependent kinase-like 5 gene (show GPD1 Antibodies) were determined to be disease-causing in epileptic encephalopathy.

  2. study presents the genotype of 2 sisters, a CDKL5 mutation c. 283-3_290del, but different phenotype

  3. Data suggest that the increased dosage of cyclin dependent kinase like 5 protein(CDKL5) might have affected interactions of this kinase with its substrates, leading to perturbation of neurodevelopmental and neurobehavioral abnormalities.

  4. It was indicated that CDKL5 controls excitatory synaptic transmission and the conditions associated with CDKL5 deviation in man indicates synaptic abnormalities.

  5. CDKL5 gene mutations accounted for 5.4% of boys with early onset epileptic encephalopathy

  6. CDKL5 gene is not useful in practical molecular diagnosis of atypical Rett syndrome.

  7. Mutations in the CDKL5 gene associtaed with Hanefield variants of Rett syndrome and early-onset epileptic encephalopathies.

  8. study described the clinical condition and characterization of two first Brazilian patients with CDKL5 mutations, including the first Brazilian case of atypical Rett related to abnormalities in this gene

  9. CDKL5 mutations cause severe epilepsy in infancy with subsequent epileptic encephalopathy.

  10. aberrations of CDKL5 and ARX combined are an important consideration in the genetic forms of early-onset epilepsy in boys

Mouse (Murine) Cyclin-Dependent Kinase-Like 5 (CDKL5) interaction partners

  1. these results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1.

  2. Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation

  3. Amph1 (show AMPH Antibodies) is the cytoplasmic substrate for CDKL5.

  4. CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes.

  5. a functional axis between MYCN (show MYCN Antibodies) and CDKL5 governing both neuron proliferation rate and differentiation.

  6. CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity.

  7. both subcellular localization and expression of CDKL5 are modulated by the activation of extrasynaptic N-methyl-D-aspartate receptors and suggest regulation of CDKL5 by cell death pathways.

  8. CDKL5 is involved in pre-mRNA processing (show PRPF39 Antibodies), by controlling splicing factor (show SLU7 Antibodies) dynamics.

  9. CDKL5 phosphorylation is required for its entrance into the nucleus whereas a portion of the COOH-terminal domain is responsible for a stable residency in this cellular compartment probably through protein-protein interactions

  10. CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail

CDKL5 Antigen Profile

Protein Summary

This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.

Gene names and symbols associated with CDKL5

  • cyclin-dependent kinase-like 5 (CDKL5) antibody
  • cyclin-dependent kinase-like 5 (cdkl5) antibody
  • cyclin-dependent kinase-like 5 (LOC100355402) antibody
  • cyclin-dependent kinase-like 5 (Cdkl5) antibody
  • BC038161 antibody
  • EIEE2 antibody
  • ISSX antibody
  • Stk9 antibody

Protein level used designations for CDKL5

cyclin-dependent kinase-like 5 , cyclin-dependent kinase-like 5-like , cyclin dependent kinase 5 transcript , serine/threonine kinase 9 , serine/threonine-protein kinase 9

GENE ID SPECIES
100057902 Equus caballus
428001 Gallus gallus
100145195 Xenopus (Silurana) tropicalis
100355402 Oryctolagus cuniculus
100407783 Callithrix jacchus
100472831 Ailuropoda melanoleuca
100583908 Nomascus leucogenys
6792 Homo sapiens
382253 Mus musculus
491761 Canis lupus familiaris
100623797 Sus scrofa
538337 Bos taurus
100362725 Rattus norvegicus
Selected quality suppliers for anti-CDKL5 (CDKL5) Antibodies
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