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Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Additionally we are shipping CDK14 Antibodies (78) and CDK14 Proteins (12) and many more products for this protein.
findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 ELISA Kits) in facilitating LRP5 (show LRP5 ELISA Kits)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y (show CCNY ELISA Kits), and LRP5 (show LRP5 ELISA Kits)/6.
these results suggest that knockdown of PFTK1 inhibited the proliferation and invasion of colon cancer cells as well as the EMT (show ITK ELISA Kits) progress by suppressing the Sonic hedgehog (show SHH ELISA Kits) signaling pathway.
we report that PFTK1 downregulation might inhibit the proliferation and invasion of NSCLC cells by suppressing the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway.
The expression level of PFTK1 was correlated with tumor grade, FIGO stage, lymph node metastasis of EOC patients as well as poor prognosis.
Knockdown of PFTK1 inhibited the proliferation and invasion of pancreatic cancer cells as well as the EMT (show ITK ELISA Kits) progress by suppressing the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway.
PFTK1 overexpression promoted proliferation, migration and invasion of gastric cancer cells, while PFTK1 knockdown led to the opposite results.
Knockdown of PFTK1 increases E-cadherin (show CDH1 ELISA Kits) expression, decreases vimentin (show VIM ELISA Kits) expression and inhibits migration of glioma cells.
Up-regulated PFTK1 might promote breast cancer progression.
Cigarette smoke down regulates CDK14 levels and impairs Wnt (show WNT2 ELISA Kits) signaling.
findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 (show MARK3 ELISA Kits) and PFTK1
may be a key regulator for thyrotropin-releasing hormone (TRH (show TRH ELISA Kits)) action in the cerebellum through the NO-cGMP pathway
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
PFTAIRE protein kinase 1
, cell division protein kinase 14
, serine/threonine-protein kinase PFTAIRE-1
, Cell division protein kinase 14