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Cyclophilin D Proteins (CYPD)

The protein encoded by CYPD is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family.

list all proteins Gene Name GeneID UniProt
Rat CYPD CYPD 361967 Q6DGG0
Human CYPD CYPD 5481 Q08752
Mouse CYPD CYPD 105675 Q99KR7
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More Proteins for Cyclophilin D (CYPD) Interaction Partners

Human Cyclophilin D (CYPD) interaction partners

  1. The thermodynamics of binding of Cyp-40 (show PPID Proteins) to Hsp90 (show HSP90 Proteins) shows remarkable temperature sensitivity in the physiological temperature range.

  2. cyclophilin-D (show PPIF Proteins) protein could increase oxidative stress and cause endothelial cell injury and apoptosis. cyclophilin-D (show PPIF Proteins) protein is the key factor in reactive oxygen species-induced mitochondrial damage, leading to apoptosis of endothelial cells.

  3. Results show that CypD interacts with SPG7 and VDAC to form the mitochondrial permeability transition pore complex (PTP)and its CsA-binding region is necessary for PTP formation.

  4. molecular determinants necessary for Cyclophilin D (show PPIF Proteins) activity regulation and binding to proposed pore constituents thereby regulating the mitochondrial permeability transition pore.

  5. Cyp-D silencing down-regulated mitochondrial transcripts initiated from the heavy strand promoter 2 [i.e., NADH dehydrogenase 1 (ND1) by 11-fold; cytochrome oxidase 1 (COX1) by 4-fold; and ATP synthase subunit 6 (ATP6) by 6.5-fold.

  6. Cyp40 binds to C2I in vitro and in intact cells, it also interacts with the enzyme components of iota toxin and CDT, suggesting a common principle for this toxin family.

  7. The Photorhabdus toxins TccC3 and TccC5 interacted with Hsp90, FKBP51, Cyp40 and CypA, suggesting a role of these host cell factors in translocation and/or refolding of the ADP-ribosyltransferases.

  8. The p53 (show TP53 Proteins)/Cyp-D (show PPIF Proteins) mitochondrial complexation was prevented by CsA (show ERCC8 Proteins) or Cyp-D (show PPIF Proteins) silencing.

  9. cisplatin-induced non-apoptotic death requires mitochondria Cyp-D (show PPIF Proteins)-p53 (show TP53 Proteins) signaling in pancreatic cancer cells

  10. CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells

Cow (Bovine) Cyclophilin D (CYPD) interaction partners

  1. Mannheimia haemolytica leukotoxin binds cyclophilin D (show PPIF Proteins) on bovine neutrophil mitochondria.

Mouse (Murine) Cyclophilin D (CYPD) interaction partners

  1. Ischemic postconditioning might prevent lethal reperfusion injury through an increased SIRT3 (show SIRT3 Proteins) activity and subsequent attenuation of CyPD acetylation at reperfusion.

  2. These findings reveal the role of HAX-1 (show HAX1 Proteins) in regulating cyclophilin-D (show PPIF Proteins) levels via an Hsp90 (show HSP90 Proteins)-dependent mechanism, resulting in protection against activation of mPTP (show PTPN2 Proteins) and subsequent cell death responses

  3. study identifies a novel signaling pathway composed of E2F1 (show E2F1 Proteins), miR (show MLXIP Proteins)-30b and CypD that regulates myocardial necrosis.

  4. It is concluded that CypD sensitizes the brain mitochondria to PT, and its inhibition by CsA (show HSPA9 Proteins) or CypD absence improves the complex I-related mitochondrial function and increases mitochondria stability against Ca(2 (show CA2 Proteins)+) stress.

  5. Data indicate that Ppif (show PPID Proteins) protein cyclophilin D (CypD)-dependent protein kinase A (PKA)/cAMP regulatory-element-binding (CREB (show CREB1 Proteins)) signaling is responsible for amyloid beta (Abeta (show APP Proteins))-induced synaptic injury.

  6. Ablation of CypD leads to changes in the mitochondrial acetylome which may contribute to altered mitochondrial metabolism in CypD-deficient mice.

  7. These results suggest a physiologic function for CypD and the mitochondrial permeability transition in the regulation of starvation-induced autophagy.

  8. new insights into CypD-dependent mitochondrial mPTP (show PTPN2 Proteins) and signaling on mitochondrial trafficking in axons and synaptic degeneration in an environment enriched for Abeta (show APP Proteins)

  9. Cys (show DNAJC5 Proteins)-203 residue of CypD is necessary for redox stress-induced activation of mPTP (show PTPN2 Proteins).

  10. Data suggest that, in mitochondria exhibiting intact inner membranes, the absence of cyclophilin D (show PPIF Proteins) or the inhibition of its binding to F(0)F(1)-ATP synthase by cyclosporin A will affect only matrix adenine nucleotides levels.

Cyclophilin D (CYPD) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A.

Gene names and symbols associated with Cyclophilin D Proteins (CYPD)

  • cyclophilin D (cypD)
  • cyclophilin D (LOC100152612)
  • peptidylprolyl isomerase D (Ppid)
  • peptidylprolyl isomerase D (PPID)
  • peptidylprolyl isomerase F (PPIF)
  • peptidylprolyl isomerase F (cyclophilin F) (Ppif)
  • AW457192 protein
  • CYP-40 protein
  • CyP-D protein
  • CyP-F protein
  • CYPD protein
  • DDBDRAFT_0205184 protein
  • DDBDRAFT_0215377 protein
  • DDB_0205184 protein
  • DDB_0215377 protein
  • PPIase protein

Protein level used designations for Cyclophilin D Proteins (CYPD)

40 kDa peptidyl-prolyl cis-trans isomerase , Cyclophilin D , PPIase D , cyclophilin-40 , peptidyl-prolyl cis-trans isomerase D , rotamase D , 40 kDa peptidyl-prolyl cis-trans isomerase D , cyclophilin 40 , cyclophilin D , cyclophilin-related protein , PPIase F , cyclophilin F , peptidyl-prolyl cis-trans isomerase F, mitochondrial , peptidyl-prolyl cis-trans isomerase, mitochondrial , peptidylprolyl isomerase F (cyclophilin F) , rotamase F , mitochondrial Cyclophilin D

GENE ID SPECIES
8622540 Dictyostelium discoideum AX4
100152612 Sus scrofa
361967 Rattus norvegicus
5481 Homo sapiens
414346 Bos taurus
423723 Gallus gallus
105675 Mus musculus
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