Cyclophilin D Proteins (CYPD)

The protein encoded by CYPD is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family.

list all proteins Gene Name GeneID UniProt
Rat CYPD CYPD 361967 Q6DGG0
Human CYPD CYPD 5481 Q08752
Mouse CYPD CYPD 105675 Q99KR7
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More Proteins for Cyclophilin D (CYPD) Interaction Partners

Human Cyclophilin D (CYPD) interaction partners

  1. Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates.

  2. This review discusses previous studies to provide comprehensive information on the physiological role of cyclophilin D as well as PTP opening in the cell that can be taken into consideration for the development of new PTP inhibitors. [review]

  3. The influx of unfolded p53 (show TP53 Proteins) into the mitochondrial matrix in response to oxidative stress indirectly activates the normally inhibited CypD by displacing it from Trap1 (show TRAP1 Proteins) complexes. This activates CypD's isomerase activity. Liberated CypD then isomerizes multiple proteins including p53 (show TP53 Proteins) (causing p53 (show TP53 Proteins) aggregation) and the structural components of the mPTP (show PTPN2 Proteins) pore, inducing pore opening.

  4. The present study is to investigate the role of CypD in regulating the mitochondrial dynamics relevant to oxidative stress induced (show SQSTM1 Proteins) neuron dysfunctions.

  5. CyPD regulates mitochondrial metabolism, and likely cell survival, by promoting more efficient electrons flow through the respiratory chain via increased supercomplex formation

  6. cyclophilin D (show PPIF Proteins) may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism

  7. The thermodynamics of binding of Cyp-40 (show PPID Proteins) to Hsp90 (show HSP90 Proteins) shows remarkable temperature sensitivity in the physiological temperature range.

  8. cyclophilin-D (show PPIF Proteins) protein could increase oxidative stress and cause endothelial cell injury and apoptosis. cyclophilin-D (show PPIF Proteins) protein is the key factor in reactive oxygen species-induced mitochondrial damage, leading to apoptosis of endothelial cells.

  9. Results show that CypD interacts with SPG7 and VDAC to form the mitochondrial permeability transition pore complex (PTP)and its CsA-binding region is necessary for PTP formation.

  10. molecular determinants necessary for Cyclophilin D (show PPIF Proteins) activity regulation and binding to proposed pore constituents thereby regulating the mitochondrial permeability transition pore.

Cow (Bovine) Cyclophilin D (CYPD) interaction partners

  1. Mannheimia haemolytica leukotoxin binds cyclophilin D (show PPIF Proteins) on bovine neutrophil mitochondria.

Mouse (Murine) Cyclophilin D (CYPD) interaction partners

  1. these data demonstrate that mitochondria are impaired in aging bone and that CypD deletion protects against this impairment to prevent bone loss. This implicates CypD-regulated MPTP (show PTPN2 Proteins) and mitochondrial dysfunction in the impairment of bone cells and in aging-related bone loss.

  2. Ppif (show PPID Proteins)+/+ and Ppif (show PPID Proteins)-/- eosinophils exhibited no significant difference in apoptosis or secondary necrosis.

  3. Ischemic postconditioning might prevent lethal reperfusion injury through an increased SIRT3 (show SIRT3 Proteins) activity and subsequent attenuation of CyPD acetylation at reperfusion.

  4. These findings reveal the role of HAX-1 (show HAX1 Proteins) in regulating cyclophilin-D (show PPIF Proteins) levels via an Hsp90 (show HSP90 Proteins)-dependent mechanism, resulting in protection against activation of mPTP (show PTPN2 Proteins) and subsequent cell death responses

  5. study identifies a novel signaling pathway composed of E2F1 (show E2F1 Proteins), miR (show MLXIP Proteins)-30b and CypD that regulates myocardial necrosis.

  6. It is concluded that CypD sensitizes the brain mitochondria to PT, and its inhibition by CsA (show HSPA9 Proteins) or CypD absence improves the complex I-related mitochondrial function and increases mitochondria stability against Ca(2 (show CA2 Proteins)+) stress.

  7. Data indicate that Ppif (show PPID Proteins) protein cyclophilin D (CypD)-dependent protein kinase A (PKA)/cAMP regulatory-element-binding (CREB (show CREB1 Proteins)) signaling is responsible for amyloid beta (Abeta (show APP Proteins))-induced synaptic injury.

  8. Ablation of CypD leads to changes in the mitochondrial acetylome which may contribute to altered mitochondrial metabolism in CypD-deficient mice.

  9. These results suggest a physiologic function for CypD and the mitochondrial permeability transition in the regulation of starvation-induced autophagy.

  10. new insights into CypD-dependent mitochondrial mPTP (show PTPN2 Proteins) and signaling on mitochondrial trafficking in axons and synaptic degeneration in an environment enriched for Abeta (show APP Proteins)

Cyclophilin D (CYPD) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A.

Gene names and symbols associated with Cyclophilin D Proteins (CYPD)

  • cyclophilin D (cypD)
  • cyclophilin D (LOC100152612)
  • peptidylprolyl isomerase D (Ppid)
  • peptidylprolyl isomerase D (PPID)
  • peptidylprolyl isomerase F (PPIF)
  • peptidylprolyl isomerase F (cyclophilin F) (Ppif)
  • AW457192 protein
  • CYP-40 protein
  • CyP-D protein
  • CyP-F protein
  • CYPD protein
  • DDBDRAFT_0205184 protein
  • DDBDRAFT_0215377 protein
  • DDB_0205184 protein
  • DDB_0215377 protein
  • PPIase protein

Protein level used designations for Cyclophilin D Proteins (CYPD)

40 kDa peptidyl-prolyl cis-trans isomerase , Cyclophilin D , PPIase D , cyclophilin-40 , peptidyl-prolyl cis-trans isomerase D , rotamase D , 40 kDa peptidyl-prolyl cis-trans isomerase D , cyclophilin 40 , cyclophilin D , cyclophilin-related protein , PPIase F , cyclophilin F , peptidyl-prolyl cis-trans isomerase F, mitochondrial , peptidyl-prolyl cis-trans isomerase, mitochondrial , peptidylprolyl isomerase F (cyclophilin F) , rotamase F , mitochondrial Cyclophilin D

GENE ID SPECIES
8622540 Dictyostelium discoideum AX4
100152612 Sus scrofa
361967 Rattus norvegicus
5481 Homo sapiens
414346 Bos taurus
423723 Gallus gallus
105675 Mus musculus
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