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Cystathionase (Cystathionine gamma-Lyase) Proteins (CTH)

CTH encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Additionally we are shipping CTH Antibodies (78) and CTH Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTH 1491 P32929
CTH 107869 Q8VCN5
CTH 24962 P18757
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Top CTH Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Yeast His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$841.50
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,102.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details

CTH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus)

Top referenced CTH Proteins

  1. Human CTH Protein expressed in Wheat germ - ABIN1350649 : Baskar, Li, Moore: Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 (PubMed)
    Show all 3 references for ABIN1350649

  2. Human CTH Protein expressed in Escherichia coli (E. coli) - ABIN667632 : Chiku, Padovani, Zhu, Singh, Vitvitsky, Banerjee: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN667632

More Proteins for Cystathionase (Cystathionine gamma-Lyase) (CTH) Interaction Partners

Human Cystathionase (Cystathionine gamma-Lyase) (CTH) interaction partners

  1. Nox4 (show NOX4 Proteins) is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.

  2. The expression of CSE was positively correlated with the severity of gastric ulcer

  3. Our study demonstrates that CSE/H2S system is regulated by miR (show MLXIP Proteins)-216a, and regulates ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux and cholesterol levels through the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.

  4. Collectively, our findings indicate that radiation could promote HCC (show FAM126A Proteins) cell invasion through EMT (show ITK Proteins) mediated by endogenous H2S/CSE signaling via the p38MAPK (show MAPK14 Proteins) pathway.

  5. 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide (show SQRDL Proteins) production and function.

  6. An increase of placental mRNA levels in the pre-eclampsia group was observed for methionine synthase (show MTR Proteins) and cystathionine gamma-lyase.

  7. GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.

  8. The miR (show MLXIP Proteins)-30 family are potentially important regulators of cystathionine gamma-lyase gene expression.

  9. The l-cysteine/cystathionine gamma lyase/hydrogen sulfide (show SQRDL Proteins) pathway is involved in melanoma progression.

  10. Substantial portion of Huntington's disease neurotoxicity appears to be attributable to cystathionine gamma-lyase deficiency.

Pig (Porcine) Cystathionase (Cystathionine gamma-Lyase) (CTH) interaction partners

  1. Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.

Mouse (Murine) Cystathionase (Cystathionine gamma-Lyase) (CTH) interaction partners

  1. H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase KO hepatocytes

  2. Endogenous cystathionine gamma-lyase/Hydrogen sulfide (show SQRDL Proteins) regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment

  3. The results of this study suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S.

  4. CSE-H2S increased PPARgamma (show PPARG Proteins) activity by direct sulfhydration at the C139 site, thereby changing glucose into triglyceride storage in adipocytes.

  5. Therefore, our data suggest that DNA hypermethylation of CpG rich region in cse promoter might contribute to the decrease of cse transcription and H2S production in macrophages, and thus contribute to atherosclerosis development.

  6. 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide (show SQRDL Proteins) production and function.

  7. These data confirm a key role for the H2S-generating enzymes Cbs (show CBS Proteins) and Cth in pulmonary vascular development and homeostasis and in lung alveolarization.

  8. GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.

  9. CTH inhibition did not affect the oviductal embryo transport, although delay of early embryo development was observed.

  10. CSE is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CSE is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.

CTH Protein Profile

Protein Summary

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.

Gene names and symbols associated with CTH

  • cystathionase (cystathionine gamma-lyase) (CTH)
  • cystathionine gamma-lyase (SCO3920)
  • cystathionine gamma-lyase (mlr1566)
  • cystathionine gamma-lyase (Ta0080)
  • cystathionine gamma-lyase (MAP3053c)
  • cystathionine gamma-lyase (SPO3344)
  • cystathionine gamma-lyase (CNN01730)
  • cystathionine gamma-lyase (Mmcs_1928)
  • cystathionine gamma-lyase (RHA1_ro06506)
  • cystathionine gamma-lyase (HNE_1212)
  • cystathionine gamma-lyase (MAV_3867)
  • cystathionine gamma-lyase (MSMEG_2394)
  • cystathionine gamma-lyase (Mvan_2142)
  • cystathionine gamma-lyase (SACE_6136)
  • cystathionine gamma-lyase (Mflv_4220)
  • cystathionine gamma-lyase (cysA)
  • cystathionase (cystathionine gamma-lyase) (cth)
  • cystathionase (cystathionine gamma-lyase) (Cth)
  • 0610010I13Rik protein
  • AI314617 protein
  • BC019483 protein
  • CSE protein
  • CTH protein
  • Cys3 protein
  • cysA protein
  • DDBDRAFT_0190313 protein
  • DDBDRAFT_0191318 protein
  • DDB_0190313 protein
  • DDB_0191318 protein
  • H protein
  • MGC75946 protein
  • SCQ11.03c protein
  • wu:fb48e03 protein
  • wu:fb58d08 protein
  • zgc:66001 protein
  • zgc:85785 protein

Protein level used designations for CTH

cystathionine gamma-lyase , cystathionase (cystathionine gamma-lyase) , fb58d08 , cysteine desulfhydrase , cysteine-protein sulfhydrase , gamma-cystathionase , homoserine deaminase , homoserine dehydratase , CTL target antigen , PRB-RA , probasin-related antigen

GENE ID SPECIES
100171474 Pongo abelii
456939 Pan troglodytes
1099356 Streptomyces coelicolor A3(2)
1225787 Mesorhizobium loti MAFF303099
1455740 Thermoplasma acidophilum DSM 1728
2721428 Mycobacterium avium subsp. paratuberculosis K-10
3195049 Ruegeria pomeroyi DSS-3
3255532 Cryptococcus neoformans var. neoformans JEC21
4110762 Mycobacterium sp. MCS
4224057 Rhodococcus jostii RHA1
4287543 Hyphomonas neptunium ATCC 15444
4525880 Mycobacterium avium 104
4534485 Mycobacterium smegmatis str. MC2 155
4648813 Mycobacterium vanbaalenii PYR-1
4945865 Saccharopolyspora erythraea NRRL 2338
4975533 Mycobacterium gilvum PYR-GCK
8616970 Dictyostelium discoideum AX4
394634 Xenopus (Silurana) tropicalis
494673 Xenopus laevis
100348407 Oryctolagus cuniculus
322055 Danio rerio
1491 Homo sapiens
479991 Canis lupus familiaris
733654 Sus scrofa
107869 Mus musculus
24962 Rattus norvegicus
100720299 Cavia porcellus
539159 Bos taurus
424716 Gallus gallus
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