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CTH encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Additionally we are shipping CTH Antibodies (78) and CTH Kits (28) and many more products for this protein.
Showing 10 out of 17 products:
Human CTH Protein expressed in Wheat germ - ABIN1350649
Baskar, Li, Moore: Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
Show all 3 references for ABIN1350649
Human CTH Protein expressed in Escherichia coli (E. coli) - ABIN667632
Chiku, Padovani, Zhu, Singh, Vitvitsky, Banerjee: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. in The Journal of biological chemistry 2009
Show all 2 references for ABIN667632
Nox4 (show NOX4 Proteins) is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.
The expression of CSE was positively correlated with the severity of gastric ulcer
Our study demonstrates that CSE/H2S system is regulated by miR (show MLXIP Proteins)-216a, and regulates ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux and cholesterol levels through the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.
Collectively, our findings indicate that radiation could promote HCC (show FAM126A Proteins) cell invasion through EMT (show ITK Proteins) mediated by endogenous H2S/CSE signaling via the p38MAPK (show MAPK14 Proteins) pathway.
3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide (show SQRDL Proteins) production and function.
An increase of placental mRNA levels in the pre-eclampsia group was observed for methionine synthase (show MTR Proteins) and cystathionine gamma-lyase.
GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.
The miR (show MLXIP Proteins)-30 family are potentially important regulators of cystathionine gamma-lyase gene expression.
The l-cysteine/cystathionine gamma lyase/hydrogen sulfide (show SQRDL Proteins) pathway is involved in melanoma progression.
Substantial portion of Huntington's disease neurotoxicity appears to be attributable to cystathionine gamma-lyase deficiency.
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase KO hepatocytes
Endogenous cystathionine gamma-lyase/Hydrogen sulfide (show SQRDL Proteins) regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment
The results of this study suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S.
CSE-H2S increased PPARgamma (show PPARG Proteins) activity by direct sulfhydration at the C139 site, thereby changing glucose into triglyceride storage in adipocytes.
Therefore, our data suggest that DNA hypermethylation of CpG rich region in cse promoter might contribute to the decrease of cse transcription and H2S production in macrophages, and thus contribute to atherosclerosis development.
These data confirm a key role for the H2S-generating enzymes Cbs (show CBS Proteins) and Cth in pulmonary vascular development and homeostasis and in lung alveolarization.
CTH inhibition did not affect the oviductal embryo transport, although delay of early embryo development was observed.
CSE is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CSE is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
, cystathionase (cystathionine gamma-lyase)
, cysteine desulfhydrase
, cysteine-protein sulfhydrase
, homoserine deaminase
, homoserine dehydratase
, CTL target antigen
, probasin-related antigen