You are viewing an incomplete version of our website. Please click to reload the website as full version.

Cystathionine-beta-Synthase Proteins (CBS)

The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Antibodies (104) and Cystathionine-beta-Synthase Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBS 24250 P32232
CBS 12411 Q91WT9
CBS 875 P35520
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Cystathionine-beta-Synthase Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Yeast His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Yeast His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,604.33
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

CBS Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , , ,
, ,

Top referenced Cystathionine-beta-Synthase Proteins

  1. Human CBS Protein expressed in Wheat germ - ABIN1348191 : Austgen, Hermann, Dantzler, Rogers, Kline: Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract. in Journal of neurophysiology 2011 (PubMed)
    Show all 4 references for ABIN1348191

More Proteins for Cystathionine-beta-Synthase (CBS) Interaction Partners

Chimpanzee Cystathionine-beta-Synthase (CBS) interaction partners

Mouse (Murine) Cystathionine-beta-Synthase (CBS) interaction partners

  1. These data confirm a key role for the H2S-generating enzymes Cbs and Cth (show CTH Proteins) in pulmonary vascular development and homeostasis and in lung alveolarization.

  2. genetic deficiency results in reduced Tet1 (show TET1 Proteins) and Tet2 expression, which leads to hypermethylation of Foxp3 (show FOXP3 Proteins), and impairment of Treg cell differentiation and immune homeostasis.

  3. Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.

  4. CBS disruption causes embryo retention and developmental delay in the mouse oviduct.

  5. CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.

  6. Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (show IL10 Proteins) production.

  7. Cbs protein expression is upregulated in brain cortex following traumatic brain injury.

  8. Brain of mice heterozygous for Cbs displays overexpression of DYR (show DHFR Proteins) kinase and SAH (show ACSM3 Proteins) hydrolase.

  9. These findings set the stage to investigate the role of CBS and the transsulfuration pathway in the generation of GSH in mouse retina.

  10. Hydrogen sulfide (show SQRDL Proteins) in the cortex and hippocampus exhibited dynamic changes after brain injury, in parallel with CBS mRNA and protein expression

Human Cystathionine-beta-Synthase (CBS) interaction partners

  1. In Asian populations, the investigated polymorphisms mapping at TCN2 (show TCN2 Proteins) and CBS genes did not provide any evidence of association with cleft lip/cleftpalate.

  2. Study found a novel association of CD2AP (show Cd2ap Proteins) with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS associated with homocysteine

  3. Cystathionine-beta-synthase carriers tend to have a higher serum total homocysteine level in the presence of folate deficiency than non-carriers

  4. CBS is involved in regulating lipid metabolism in ovarian cancer cells.

  5. In addition to being a potential source of superoxide radical, CBS constitutes a previously unrecognized source of NO(*)and peroxynitrite.

  6. The H2S-producing enzyme cystathionine beta-synthase (CBS), sustaining cellular bioenergetics in colorectal cancer cells, plays a role in the interplay between gasotransmitters. (Review)

  7. CBS expression is elevated in breast cancer.

  8. AdoMet (show MAT1A Proteins) binding significantly enhances CBS inhibition by carbon monoxide.

  9. Cystathionine beta-synthase-derived hydrogen sulfide (show SQRDL Proteins) is involved in human malignant hyperthermia.

  10. Propose that a distinct group of heme-responsive CBS mutations may exist in homocystinuria, which can be rescued using heme arginate.

Cystathionine-beta-Synthase (CBS) Protein Profile

Protein Summary

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with CBS

  • cystathionine-beta-synthase (cbs-a)
  • cystathionine-beta-synthase (cbs)
  • cystathionine beta-synthase (Cbs)
  • cystathionine-beta-synthase (CBS)
  • cystathionine beta-synthase (CNA06170)
  • cystathionine beta-synthase (Tb11.02.5400)
  • cystathionine beta-synthase CBS (cbs)
  • cystathionine beta-synthase (cbs)
  • cystathionine beta-synthase (cysB)
  • cystathionine beta synthase (Cbs)
  • cystathionine-beta-synthase (cbs-b)
  • cystathionine-beta-synthase b (cbsb)
  • AI047524 protein
  • AI303044 protein
  • cb442 protein
  • cbs protein
  • DDBDRAFT_0189727 protein
  • DDBDRAFT_0191292 protein
  • DDB_0189727 protein
  • DDB_0191292 protein
  • GB12529 protein
  • HIP4 protein
  • wu:fb37g05 protein
  • wu:fm61c07 protein
  • wu:fq06c06 protein
  • zgc:113704 protein

Protein level used designations for CBS

cystathionine-beta-synthase , cystathionine beta-synthase , cystathionine beta-synthase CBS , beta-thionase , hemoprotein H-450 , serine sulfhydrase , methylcysteine synthase

GENE ID SPECIES
380308 Xenopus laevis
493533 Xenopus (Silurana) tropicalis
551341 Apis mellifera
736626 Pan troglodytes
3253577 Cryptococcus neoformans var. neoformans JEC21
3665875 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4551426 Mycobacterium ulcerans Agy99
6228672 Mycobacterium marinum M
7006755 Rhodospirillum centenum SW
7705918 Gemmatimonas aurantiaca T-27
7712188 Rhodococcus erythropolis PR4
7746532 Rhodococcus opacus B4
8616308 Dictyostelium discoideum AX4
100136726 Oncorhynchus mykiss
100635325 Amphimedon queenslandica
24250 Rattus norvegicus
12411 Mus musculus
446655 Xenopus laevis
418545 Gallus gallus
875 Homo sapiens
611071 Canis lupus familiaris
514525 Bos taurus
100008766 Oryctolagus cuniculus
266987 Danio rerio
Selected quality suppliers for Cystathionine-beta-Synthase Proteins (CBS)
Did you look for something else?