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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Antibodies (100) and Cystathionine-beta-Synthase Kits (11) and many more products for this protein.
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Human CBS Protein expressed in Wheat germ - ABIN1348191
Austgen, Hermann, Dantzler, Rogers, Kline: Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract. in Journal of neurophysiology 2011
Show all 4 references for ABIN1348191
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (show CTH Proteins) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 (show TET1 Proteins) and Tet2 expression, which leads to hypermethylation of Foxp3 (show FOXP3 Proteins), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (show IL10 Proteins) production.
Cbs protein expression is upregulated in brain cortex following traumatic brain injury.
Brain of mice heterozygous for Cbs displays overexpression of DYR (show DHFR Proteins) kinase and SAH (show ACSM3 Proteins) hydrolase.
These findings set the stage to investigate the role of CBS and the transsulfuration pathway in the generation of GSH in mouse retina.
Hydrogen sulfide (show SQRDL Proteins) in the cortex and hippocampus exhibited dynamic changes after brain injury, in parallel with CBS mRNA and protein expression
Cystathionine-beta-synthase carriers tend to have a higher serum total homocysteine level in the presence of folate deficiency than non-carriers
CBS is involved in regulating lipid metabolism in ovarian cancer cells.
In addition to being a potential source of superoxide radical, CBS constitutes a previously unrecognized source of NO(*)and peroxynitrite.
The H2S-producing enzyme cystathionine beta-synthase (CBS), sustaining cellular bioenergetics in colorectal cancer cells, plays a role in the interplay between gasotransmitters. (Review)
CBS expression is elevated in breast cancer.
AdoMet (show MAT1A Proteins) binding significantly enhances CBS inhibition by carbon monoxide.
Cystathionine beta-synthase-derived hydrogen sulfide (show SQRDL Proteins) is involved in human malignant hyperthermia.
Propose that a distinct group of heme-responsive CBS mutations may exist in homocystinuria, which can be rescued using heme arginate.
Results imply that in acute ischemic conditions, CBS is upregulated and activated by truncation causing an increased production of hydrogen sulfide (show SQRDL Proteins), which exacerbate the ischemic injuries
The study elucidates a molecular mechanism for increased cysteine and therefore glutathione, synthesis via glutathionylation of CBS.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase