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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Proteins (30) and Cystathionine-beta-Synthase Kits (17) and many more products for this protein.
Showing 10 out of 123 products:
Human Monoclonal CBS Primary Antibody for IHC (p), IP - ABIN560206
Schicho, Krueger, Zeller, Von Weyhern, Frieling, Kimura, Ishii, De Giorgio, Campi, Schemann: Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. in Gastroenterology 2006
Show all 38 Pubmed References
Human Polyclonal CBS Primary Antibody for ELISA, WB - ABIN560204
Ali, Whiteman, Low, Moore: Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway. in The Journal of endocrinology 2007
Show all 11 Pubmed References
Cow (Bovine) Polyclonal CBS Primary Antibody for IHC, WB - ABIN2782348
Urreizti, Asteggiano, Bermudez, Córdoba, Szlago, Szlago, Grosso, de Kremer, Vilarinho, DAlmeida, Martínez-Pardo, Peña-Quintana, Dalmau, Bernal, Briceño, Couce, Rodés, Vilaseca, Balcells, Grinberg: The p.T191M mutation of the CBS gene is highly prevalent among homocystinuric patients from Spain, Portugal and South America. in Journal of human genetics 2006
Show all 9 Pubmed References
Human Polyclonal CBS Primary Antibody for WB - ABIN514085
Qi, Zhou, Xiao, Tao, Gu, Jiang, Xu: Promoter demethylation of cystathionine-?-synthetase gene contributes to inflammatory pain in rats. in Pain 2012
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Human Polyclonal CBS Primary Antibody for ELISA, WB - ABIN560205
Li, Chen, Muh, Li: Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats. in Hypertension 2006
Show all 2 Pubmed References
Human Polyclonal CBS Primary Antibody for FACS, IF - ABIN1881141
Lee, Mariappan, Feliers, Cavaglieri, Sataranatarajan, Abboud, Choudhury, Kasinath: Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. in The Journal of biological chemistry 2012
Show all 2 Pubmed References
Human Monoclonal CBS Primary Antibody for IF, IHC (p) - ABIN514088
Majtan, Freeman, Smith, Burstyn, Kraus: Purification and characterization of cystathionine ?-synthase bearing a cobalt protoporphyrin. in Archives of biochemistry and biophysics 2011
showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (show CTH Antibodies) slightly ameliorates the outcome of LPS (show TLR4 Antibodies)-induced endotoxemia in vivo.
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (show CTH Antibodies) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 (show TET1 Antibodies) and Tet2 (show TET2 Antibodies) expression, which leads to hypermethylation of Foxp3 (show FOXP3 Antibodies), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha (show PPARGC1A Antibodies) specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (show IL10 Antibodies) production.
Cbs protein expression is upregulated in brain cortex following traumatic brain injury.
Brain of mice heterozygous for Cbs displays overexpression of DYR (show DHFR Antibodies) kinase and SAH (show ACSM3 Antibodies) hydrolase.
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
SNPs in CBS were not related to relevant changes in homocysteine levels in coronary artery disease patients or controls.
The CBS rs2124459 was associated with a reduced risk of cleft palate in both French and Belgian populations. These results highlight the prominent involvement of the vitamin B6-dependent transsulfuration pathway of homocysteine in orofacial cleft risk and the interest for evaluating vitamin B6 status in further population studies.
There is no ordinary conjunction between human CBS and severe sepsis/septic shock, but CBS genotypes are involved in disease susceptibility.
Oligomeric status of human cystathionine beta-synthase modulates AdoMet (show MAT1A Antibodies) binding.
Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR (show MTHFR Antibodies); C677T; A1298C) and cystathionine-beta-synthase (CBS; T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.
results indicate that binding of SAM (show TTN Antibodies) to regulatory and stabilizing sites in CBS may have evolved to display an exquisite thermodynamic and structural specificity towards SAM (show TTN Antibodies) as well as the ability to transduce the allosteric signal responsible for CBS activation.
CBS 844ins68 polymorphisms were not associated with Oral squamous cell carcinoma risk in southeastern Brazilians.
This is the first mutational analysis of CBS done in a Filipino patient with classic homocystinuria who presented with a novel duplication mutation and a novel missense mutation.
Two novel compound heterozygous mutations in the CBS gene, c.407T > C (p. L136P) and c.473C > T (p.A158V), were identified in the three patients of a Han Chinese family with homocystinuria
These findings indicate that greater synthesis of phosphatidylcholine (show SGMS1 Antibodies) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase