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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Additionally we are shipping CST8 Antibodies (63) and CST8 Kits (3) and many more products for this protein.
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We show with phylogenetic relations that the CTES genes are clustered into three original groups, a testatin, a Cres, and a CstL1 group
studies show that cystatin-related epididymal spermatogenic protein is present in the sperm equatorial segment and becomes accessible to the extracellular environment during fertilization
A 14-kDa CRES isoform resides in the outer dense fibers (show ODF1 Proteins) of the sperm tail.
data on the antimicrobial activities of CRES protein suggest that it is a novel and innate antimicrobial protein which protecting the male reproductive tract against invading pathogens
CRES may be a regulator of PC4 (show IFRD1 Proteins) in sperm-egg interaction and fertilization.
loss of CRES has a significant impact on the structure and functions of the testis and epididymis. However, the observed pathologies were prevalent in aged but not in younger adult mice, suggesting that the effects of the loss of CRES are cumulative
These results suggest that mice lacking CRES may have altered local levels of cAMP/PKA activity, or that the CRES defect does not directly involve cAMP/PKA but other signaling pathways that regulate protein tyrosine phosphorylation and capacitation.
CRES is a new cross-class inhibitor that may regulate PC2 (show CBX4 Proteins) of PC2 (show CBX4 Proteins)-like proteases and suggests a role for CRES in the regulation of prohormone and proprotein processing.
cystatin-related epididymal spermatogenic protein (CRES) is a competitive inhibitor of prohormone convertase 2 (show PCSK2 Proteins) and may regulate proprotein processing within the reproductive and neuroendocrine systems
Cres promoter contains the DNA elements necessary for germ cell and pituitary gland-specific expression but lacks critical sequences necessary for expression in the epididymis and ovary.
studies suggest that Cres mRNA and protein are low at peak gonadotrope secretory activity, possibly as a means to allow proprotein processing events to occur that are integral to gonadotrope function
The Cres gene displays a specific age-dependent expression pattern in mouse testis and epididymis on both the mRNA and protein level.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined.
, cystatin-related epididymal spermatogenic protein
, cystatin 8 (cystatin-related epididymal spermatogenic)
, cystatin-related epididymal-specific protein