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CRIM1 encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. Additionally we are shipping CRIM1 Antibodies (34) and CRIM1 Kits (6) and many more products for this protein.
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Crim1 regulates integrin signaling in murine lens development
CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development.
Vascular endothelial cell-specific conditional compound heterozygotes for Crim1 and Vegfa (show VEGFA Proteins) exhibit a phenotype that is more severe than each single heterozygote and indistinguishable from that of the conditional homozygotes.
Report the involvement of both endothelial cells and monocytes in the development of progressive renal fibrosis in Crim1 mutant mice.
Crim1 mutations are associated with defects in papillary development and progression to chronic kidney disease later in life.
Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen (show GYS1 Proteins) trophoblast cells.
CRIM1 has a role in capillary formation and maintainance during angiogenesis
CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.
Crim1 regulates the delivery of VEGF-A (show VEGFA Proteins) by the podocytes to the endothelial cells
primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development
These observations provide evidence for the first time that CRIM1 plays a role in cancer cells by enhancing the migration and adhesion and increasing the expression of N-CAD and E-CAD.
Knock down of CRIM1 had no effect on VEGF (show VEGFA Proteins)-induced proliferation or migration of umbilical vein endothelial cells (HUVECs), indicating that basal CRIM1 is not involved in the proliferation or migration of endothelial cells.
Data suggest that CRIM1 plays role in cancer progression/metastasis, epithelial-mesenchymal transition, and neoplastic angiogenesis. [REVIEW]
BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.
CRIM1 is an early response gene in the presence of both angiogenic stimulation (VEGF (show VEGFA Proteins)) and environmental (extracellular matrix) factors, and Erk (show EPHB2 Proteins) and FAK (show PTK2 Proteins) might be involved in the upregulation of CRIM1 mRNA expression in vascular endothelial cells.
Study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance.
CRIM1 has a role in capillary formation and maintenance during angiogenesis
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins.
cysteine rich transmembrane BMP regulator 1 (chordin-like)
, cysteine-rich motor neuron 1 protein
, cysteine-rich motor neuron 1
, cysteine-rich motor neuron 1 protein-like
, cysteine rich transmembrane BMP regulator 1
, cysteine-rich repeat-containing protein S52
, cysteine-rich motorneuron 1