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Cysteine-Rich, Angiogenic Inducer, 61 Proteins (CYR61)

The secreted protein encoded by CYR61 is growth factor-inducible and promotes the adhesion of endothelial cells. Additionally we are shipping CYR61 Antibodies (182) and CYR61 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYR61 16007 P18406
CYR61 3491 O00622
CYR61 83476 Q9ES72
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Top CYR61 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$808.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_HEK-293 Cells Human Fc Tag   50 μg Log in to see 5 Days
$313.50
Details
Yeast Mouse His tag   500 μg Log in to see 56 to 66 Days
$962.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,960.83
Details

CYR61 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, , ,
Rat (Rattus)

Top referenced CYR61 Proteins

  1. Human CYR61 Protein expressed in Wheat germ - ABIN1351026 : Jeansonne, Pacifici, Lassak, Reiss, Russo, Zabaleta, Peruzzi: Differential Effects of MicroRNAs on Glioblastoma Growth and Migration. in Genes 2014 (PubMed)
    Show all 16 references for ABIN1351026

More Proteins for Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) Interaction Partners

Mouse (Murine) Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) interaction partners

  1. CCN1 (show CCNA2 Proteins) exacerbates tracheal obliterative bronchiolitis by enhancing fibroproliferation via an alphavbeta3-integrin-independent pathway.

  2. Data show that RNA silencing of CCN family member 1 protein (CCN1 (show CCNA2 Proteins)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling in mouse pup model of oxyge (show AKT1 Proteins)n-induced retinopathy (OIR).

  3. These findings reveal a critical role for CCN1 (show CCNA2 Proteins) in restoring mucosal homeostasis after intestinal injury

  4. CCN1 (show CCNA2 Proteins) is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR (show EGFR Proteins)-dependent hepatocyte compensatory proliferation

  5. Both knockin mice expressing a mutant CCN1 (show CCNA2 Proteins) that is unable to bind alphavbeta3/alphavbeta5 and mice with Ccn1 (show CCNA2 Proteins) knockdown are defective in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing.

  6. CYR61 is upregulated in acute lung injury (ALI) and CYR61 overexpression exacerbates ALI in mice.

  7. miR (show MLXIP Proteins)-155 functions in tandem with CCN1 (show CCNA2 Proteins) to modulate inflammation-induced vascular homeostasis and repair.

  8. MRTF-A promotes microvessel growth (via CCN1 (show CCNA2 Proteins)) and maturation (via CCN2 (show CTGF Proteins)), thereby enabling functional improvement of ischaemic muscle tissue

  9. CCN1-integrin binding increased the expression of and association between SHP-1 and VEGF-R2, which leads to rapid dephosphorylation of VEGF-R2 tyrosine, thus preventing endothelial cell hyperproliferation.

  10. CYR61 silencing can blunt the malignant behavior of osteosarcoma tumor cells by limiting primary tumor growth and dissemination process.

Human Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) interaction partners

  1. Data show that RNA silencing of CCN family member 1 protein (CCN1 (show CCNA2 Proteins)) inhibits umbilical vein endothelial cell (HUVEC) proliferation under hypoxic conditions by inhibiting phosphoinositide 3-kinase (PI3K (show PIK3CA Proteins))/AKT (show AKT1 Proteins) protein signaling.

  2. Studies indicate that the CYR61 CTGF (show CTGF Proteins) NOV (show NOV Proteins) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Proteins), CCN2 (show CTGF Proteins), CCN3 (show NOV Proteins), CCN4 (show WISP1 Proteins), CCN5 (show WISP2 Proteins) and CCN6 (show WISP3 Proteins) and have been identified in various types of cancer.

  3. Results suggest that Cyr61 is induced by EGF (show EGF Proteins) through the ERK (show EPHB2 Proteins)/CREB (show CREB1 Proteins) signal pathway and that it plays a crucial role in the migration and invasion of anaplastic thyroid cancer cells.

  4. CCN1 (show CCNA2 Proteins) is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR (show EGFR Proteins)-dependent hepatocyte compensatory proliferation

  5. we demonstrate that NF2 (show NF2 Proteins) negatively controls the invasiveness of Glioblastoma multiforme through YAP (show YAP1 Proteins)-dependent induction of CYR61/CCN1 and miR (show MLXIP Proteins)-296-3p.

  6. c-Src (show SRC Proteins) regulates secreted proteins, including the exosomal Cyr61, which are involved in modulating the metastatic potential of triple negative breast cancer cells.

  7. Report shows evidence that CCN1 (show CCNA2 Proteins) is O-fucosylated at Threonine 242 and that O-fucosylation of CCN1 (show CCNA2 Proteins) regulates its secretion.

  8. Reactive oxygen species increased c-Jun (show JUN Proteins), a critical member of transcription factor AP-1 (show JUN Proteins) complex, and increased c-Jun (show JUN Proteins) binding to the AP-1 (show FOSB Proteins) site of the CCN1 (show CCNA2 Proteins) promoter.

  9. Overexpression of Cyr61 may induce epithelial-mesenchymal transition and therefore leads to laryngeal squamous- cell carcinoma invasion and metastasis and poor prognosis.

  10. Cyr61 promotes CD204 expression and the migration of macrophages via MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway in esophageal squamous cell carcinoma

Cow (Bovine) Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) interaction partners

  1. The increased expression of CYR61 in the Day 4 corpus lutum (CL) and its transient increase by prostaglandin F2alpha in Day 6, Day 10, and Day 16 CL indicate that CYR61 may play a role in regulating angiogenesis over the life span of the CL.

  2. Together, these results indicate that Cyr61 is an important determinant of the genetic reprogramming that occurs in mechanically challenged cells.

  3. Mechanical regulation of the Cyr61 gene in smooth muscle cells

CYR61 Protein Profile

Protein Summary

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.

Gene names and symbols associated with CYR61

  • cysteine-rich, angiogenic inducer, 61 (cyr61)
  • cysteine-rich, angiogenic inducer, 61 (CYR61)
  • small ubiquitin-like modifier 3 (sumo3)
  • cysteine-rich, angiogenic inducer, 61 (LOC100230216)
  • cysteine rich protein 61 (Cyr61)
  • cysteine-rich, angiogenic inducer, 61 (Cyr61)
  • AI325051 protein
  • CCN1 protein
  • CYR61 protein
  • cyr61-l2 protein
  • GIG1 protein
  • IGFBP10 protein
  • MGC69281 protein
  • MGC69539 protein
  • smt3a protein
  • smt3h1 protein
  • sumo-3 protein
  • Xcyr61 protein
  • zgc:158158 protein

Protein level used designations for CYR61

cysteine-rich, angiogenic inducer, 61 , SMT3 suppressor of mif two 3 homolog 3 , small ubiquitin-related modifier 3 , protein CYR61-like , 3CH61 , CCN family member 1 , IBP-10 , IGF-binding protein 10 , IGFBP-10 , cysteine-rich angiogenic inducer 61 , insulin-like growth factor binding protein 10 , insulin-like growth factor-binding protein 10 , intermediate early , protein CYR61 , cysteine-rich heparin-binding protein 61 , cysteine-rich, anigogenic inducer, 61 , cysteine rich protein 61 , secreted cysteine-rich protein cyr61

GENE ID SPECIES
448140 Xenopus (Silurana) tropicalis
553273 Danio rerio
714970 Macaca mulatta
100125978 Xenopus (Silurana) tropicalis
100230216 Taeniopygia guttata
100413443 Callithrix jacchus
100445022 Pongo abelii
100471762 Ailuropoda melanoleuca
16007 Mus musculus
3491 Homo sapiens
83476 Rattus norvegicus
429089 Gallus gallus
379598 Xenopus laevis
479967 Canis lupus familiaris
508941 Bos taurus
456988 Pan troglodytes
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