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CRIP2 encodes a putative transcription factor with two LIM zinc-binding domains. Additionally we are shipping CRIP2 Antibodies (50) and many more products for this protein.
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The persistence of Crip2 expression in cardiovascular tissues implies that Crip2 might exert an important impact on the cardiovascular development, maintenance and homeostasis.
role for the two LIM (show PDLIM5 Proteins)-domain gene Hlp (show HAP1 Proteins) in the very earliest stages of heart differentiation and development
observed characteristics of the LIM domain-containing adaptor protein CRIP2 are consistent with a potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton
Function of avian CRIP2 in smooth muscle differentiation
CRIP2 expression is down-regulated in ESCC tissues and cell lines.
CRIP2 acts as a transcription repressor of the NF-kappaB (show NFKB1 Proteins)-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis
These findings suggest that ADAM19 (show Adam19 Proteins) autolysis is activated by lipopolysaccharide and that ADAM19 (show Adam19 Proteins) promotes the secretion of CRIP2.
Crip2 plays an important role in atrioventricular valve development by downregulating the expression of extracellular matrix components in the endocardial cushion.
data suggest a specific role for Wnt3a (show WNT3A Proteins) in the development of cardiac NCCs; propose that this function of wnt3a (show WNT3A Proteins) in r6 is partially mediated by crip2 expression in the premigratory cardiac NCCs, which subsequently affects cardiac function and PA patterning
This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants.
, LIM only protein HLP
, cysteine-rich protein 2
, heart LIM protein
, Cysteine-rich intestinal protein
, LIM domain protein ESP1/CRP2
, LIM/double zinc-finger protein