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Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) Proteins (CFTR)

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Additionally we are shipping CFTR Antibodies (87) and CFTR Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CFTR 12638 P26361
Rat CFTR CFTR 24255 P34158
CFTR 1080 P13569
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Top CFTR Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CFTR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaction Partners

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR

  2. Study conclude that when both CFTR and NPT2a (show SLC34A1 Proteins) are expressed in X. laevis oocytes, CFTR confers to NPT2a (show SLC34A1 Proteins) a cAMPi-dependent trafficking to the membrane.

  3. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  4. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (show ABCB6 Proteins)) transporters.

  5. These data suggest that the Xenopus P2Y1 receptor (show P2RY1 Proteins) can increase both cyclic AMP (show TMPRSS5 Proteins)/protein kinase A and calcium/protein kinase C levels and that the PKC pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. CFTR expressed by alveolar or peritoneal macrophages regulates acute proinflammatory responses.

  2. CFTR silencing in pancreatic beta-cells significantly reduced insulin (show INS Proteins) output in response to glucose, and made the cells more sensitive to oxidative stress.

  3. Cftr KO crypt epithelium maintains an alkaline pHi as a consequence of losing both Cl(-) and HCO3 (-) efflux, which impairs pHi regulation by Ae2 (show SLC4A2 Proteins).

  4. Data suggest that the deltaF508 Cftr mutation (the most frequent CFTR mutation in cystic fibrosis (show S100A8 Proteins) in humans) is associated with worsening insulin (show INS Proteins) resistance and down-regulation of insulin (show INS Proteins) secretion from pancreatic beta cells as mutant mice age.

  5. Second-hand cigarette impairs bacterial phagocytosis by modulating CFTR dependent lipid-rafts.

  6. CFTR Cl- channel is a molecular target of natural compounds EGCG and ECG.

  7. lipoxin A4 and PAF (show KIAA0101 Proteins) are involved in E. coli or LPS (show TLR4 Proteins)-induced lung inflammation in CFTR-deficient mice.

  8. Osteoblast dysfunctions in DeltaF508-CFTR mice result from altered NF-kappaB (show NFKB1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  9. CFTR and BECN1 (show BECN1 Proteins) function can be restored with cysteamine and EGCG in a model of the F508del-CFTR mutation

  10. The data of this study strengthen the notion that microvillar cells in the OE play a key role in maintaining tissue homeostasis and identify several mechanisms underlying this regulation through the multiple functions of CFTR.

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. G551D-bearing Cystic fibrosis (show S100A8 Proteins) patients had significantly higher expression of active CD11b (show ITGAM Proteins) on polymorphonuclear neutrophils and of CD63 (show CD63 Proteins) on monocytes.

  2. We found that cyclophosphamide significantly enhanced long-term expression of the transgenic human CFTR and the reporter gene LacZ (show GLB1 Proteins) by reducing host immune responses.

  3. The study helps expand our knowledge of rare CFTR mutations in a minority population and may have important clinical implications for personalized therapeutic intervention.

  4. Studies indicate that the main strategies used in the molecular diagnosis of cystic fibrosis (show S100A8 Proteins) are detecting and sequencing of the entire coding region of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

  5. adenovirusmediated CFTR overexpression enhanced cell invasion and motility of serous ovarian cancer cells in vitro.

  6. Letter/Case Report: high penetrance of the PRSS1 (show PRSS1 Proteins) A16V mutation caused by SPINK1 (show SPINK1 Proteins) N34S and CFTR TG11-5T co-mutations associated with pancreatitis.

  7. The most common cystic fibrosis (show S100A8 Proteins) causing mutation is the deletion of F508 from the first Nucleotide Binding Domain (F508del-NBD1). The study releals the mechanism of action of deleterious, rescuing, and stabilizing perturbations to NBD1 from CFTR.

  8. KCa3.1 (show KCNN4 Proteins) and CFTR colocalize at the plasma membrane.

  9. Studies suggest that subtle changes in cystic fibrosis transmembrane conductance regulator (CFTR) structure can affect strongly channel function and the action of cystic fibrosis (show S100A8 Proteins) (CF) mutations.

  10. Analysis of long-range interactions in primary human cells identifies novel cooperative CFTR regulatory elements.

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1 (show TGFB1 Proteins), via TGF-beta1 (show TGFB1 Proteins) receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG (show SNRPG Proteins)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (show S100A8 Proteins) are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (show S100A8 Proteins) pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas (show AVP Proteins) deferens and/or epididymis atresia at birth

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (show DNASE1 Proteins) hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results demonstrate functional coupling between Cftr and Slc26a6 (show SLC26A6 Proteins)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

CFTR Protein Profile

Protein Summary

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Gene names and symbols associated with CFTR

  • cystic fibrosis transmembrane conductance regulator (cftr-A)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR)
  • cystic fibrosis transmembrane conductance regulator (Cftr)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (Cftr)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr)
  • cystic fibrosis transmembrane conductance regulator homolog (Cftr)
  • abc35 protein
  • abcc7 protein
  • AW495489 protein
  • CF protein
  • CFTR protein
  • cftr/mrp protein
  • dJ760C5.1 protein
  • mrp7 protein
  • RGD1561193 protein
  • tnr-cftr protein
  • xcftr protein

Protein level used designations for CFTR

cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase

GENE ID SPECIES
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
1080 Homo sapiens
100049619 Gallus gallus
492302 Canis lupus familiaris
403154 Sus scrofa
281067 Bos taurus
100009471 Oryctolagus cuniculus
100719898 Cavia porcellus
100071259 Equus caballus
443347 Ovis aries
100381094 Xenopus laevis
100137035 Pongo abelii
463674 Pan troglodytes
100126675 Papio anubis
100135647 Cavia porcellus
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