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anti-Cystinosis, Nephropathic (CTNS) Antibodies

CTNS encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Additionally we are shipping CTNS Proteins (8) and CTNS Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CTNS 365969 Q9WTR6
CTNS 1497 O60931
CTNS 287478  
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Top anti-CTNS Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB CTNS Antibody (C-term) (ABIN1881240) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the CTNS antibody detected the CTNS protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Ctns  Sample Tissue: Mouse Lung lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB CTNS monoclonal antibody (M09), clone 5G6. Western Blot analysis of CTNS expression in HepG2. Detection limit for recombinant GST tagged CTNS is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB Western Blot analysis of CTNS expression in transfected 293T cell line by CTNS MaxPab polyclonal antibody.Lane 1: CTNS transfected lysate(45.10 KDa).Lane 2: Non-transfected lysate. CTNS MaxPab rabbit polyclonal antibody. Western Blot analysis of CTNS expression in human stomach. 100 μg Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated WB CTNS monoclonal antibody (M09), clone 5G6 Western Blot analysis of CTNS expression in HepG2. Detection limit for recombinant GST tagged CTNS is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated IHC (p), ELISA Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with CTNS antibody ABIN305720 at 1.25 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

CTNS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Human , , ,
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Rat (Rattus) ,
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Top referenced anti-CTNS Antibodies

  1. Human Polyclonal CTNS Primary Antibody for WB - ABIN1881240 : Taranta, Wilmer, van den Heuvel, Bencivenga, Bellomo, Levtchenko, Emma: Analysis of CTNS gene transcripts in nephropathic cystinosis. in Pediatric nephrology (Berlin, Germany) 2010 (PubMed)
    Show all 5 references for ABIN1881240

  2. Human Monoclonal CTNS Primary Antibody for ELISA, WB - ABIN560527 : Bellomo, Corallini, Pastore, Palma, Laurenzi, Emma, Taranta: Modulation of CTNS gene expression by intracellular thiols. in Free radical biology & medicine 2010 (PubMed)
    Show all 2 references for ABIN560527

  3. Human Polyclonal CTNS Primary Antibody for WB - ABIN514757 : Sumayao, McEvoy, Martin-Martin, McMorrow, Newsholme: Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line. in Experimental physiology 2013 (PubMed)

More Antibodies against CTNS Interaction Partners

Mouse (Murine) Cystinosis, Nephropathic (CTNS) interaction partners

  1. Data indicate that hematopoietic stem cell (HSC (show FUT1 Antibodies)) transplantation in cystinosin knockout (Ctns-/-) thyroid drastically decreased cystine accumulation and normalized the thyroid-stimulating hormone level.

  2. Cells and tissues lacking CTNS expression are characterized by increased autophagosome numbers, but functional macroautophagic flux.

  3. The Ctns(-/-) mouse model generated on C57BL/6 background is not suitable for clarifying the pathogenesis of male infertility in cystinosis.

  4. Deletion of cystinosis gene (Ctns) causes corneal cystine crystals formation, neovascularization and scarring in the cornea of ctns transgenic mice mimicking cystinosis in humans.

  5. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle (show LRMP Antibodies), formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase (show OPLAH Antibodies)

  6. CTNS has a role in proper functioning of the retina and bones, and in mouse behavior

  7. Temporospatial pattern of cystine accumulation in Ctns-/- mice parallels that of patients and validates the mice as a model for the ocular anomalies of cystinosis.

Human Cystinosis, Nephropathic (CTNS) interaction partners

  1. cystinosin-deficient cells had abnormal shape and distribution of the endo-lysosomal compartments and impaired endocytosis, with decreased surface expression of multiligand receptors and delayed lysosomal cargo processing.

  2. CTNS-LKG represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions.

  3. identified two novel CTNS splicing deletions in a Chinese IC family, one at the donor site of exon 6 of CTNS and the other at the acceptor site of exon 8

  4. We recommend that black South African and Cape Coloured patients presenting with cystinosis be tested for CTNS-c.971-12G > A in the first instance, with the possibility of prenatal testing being offered to at-risk families.

  5. Cystinosin, MPDU1 (show MPDU1 Antibodies), SWEETs and KDELR (show KDELR Antibodies) belong to a well-defined protein family with putative function of cargo receptors.[cytonosin]

  6. results objectify the pigmentation defect in patients with cystinosis. We also identify the role of CTNS in melanogenesis and add a new gene to the list of the genes involved in the control of skin and hair pigmentation

  7. Mutation analysis of CTNS in six cystinosis patients from four families in Thailand. Using PCR sequencing of the entire coding regions, study identified all eight mutant alleles, including two mutations, p.G309D and p.Q284X, that have not been previously reported.

  8. Report CTNS mutations in Turkish cystinosis patients.

  9. cystinosin exports the proteolysis-derived dimeric amino acid cystine from lysosomes and is impaired in cystinosis.

  10. CTNS plays a pivotal role in regulating cell thiol concentrations.

CTNS Antigen Profile

Protein Summary

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CTNS

  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11) antibody
  • cystinosin, lysosomal cystine transporter (CTNS) antibody
  • cystinosin, lysosomal cystine transporter (ctns) antibody
  • cystinosis, nephropathic (CTNS) antibody
  • cystinosis, nephropathic (ctns) antibody
  • cystinosin, lysosomal cystine transporter (Ctns) antibody
  • cystinosis, nephropathic (Ctns) antibody
  • 9930009M05Rik antibody
  • AI195360 antibody
  • AI451155 antibody
  • AW049661 antibody
  • CTNS antibody
  • CTNS-LSB antibody
  • PQLC4 antibody
  • sut antibody
  • xCT antibody
  • zgc:110194 antibody

Protein level used designations for CTNS

amino acid transport system xc- , cysteine/glutamate transporter , cystine/glutamate transporter , sodium independent anionic amino acid transport system , solute carrier family 7 member 11 , cystinosis, nephropathic , cystinosin , cystinosin-like , cystinosin, lysosomal cystine transporter

GENE ID SPECIES
365969 Mus musculus
417606 Gallus gallus
431937 Xenopus laevis
491220 Canis lupus familiaris
553594 Danio rerio
706721 Macaca mulatta
748043 Pan troglodytes
780074 Xenopus (Silurana) tropicalis
100060554 Equus caballus
100223329 Taeniopygia guttata
100409361 Callithrix jacchus
100443212 Pongo abelii
100592953 Nomascus leucogenys
1497 Homo sapiens
613527 Bos taurus
287478 Rattus norvegicus
83429 Mus musculus
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