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The protein encoded by CYCSP51 belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily.
PDE7A (show PDE7A Antibodies) is a high-speed and low-affinity phosphodiesterase for cCMP.
Ubiquitous expression of phosphodiesterase 7A (show PDE7A Antibodies) in human proinflammatory and immune cells; PDE7A (show PDE7A Antibodies) was expressed in neutrophils and alveolar macrophages
crystal structure of PDE7A1 catalytic domain complexed with the inhibitor 3 (show PPP1R11 Antibodies)-isobutyl-1-methylxanthine & kinetic analysis on mutant PDE7A1 and PDE4D2; results show several residues must work together to switch inhibitor selectivity between PDE4 (show PDE4A Antibodies) & PDE7
Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT (show SLC46A1 Antibodies)) mutant mice.
Hemochromatosis (show HFE Antibodies) is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.
In vivo folate uptake experiments demonstrated a systemic folate deficiency caused by disruption of PCFT (show SLC46A1 Antibodies)-mediated intestinal folate uptake, thus confirming in vivo a critical role of the PCFT (show SLC46A1 Antibodies) protein in intestinal folate transport and erythropoiesis.
heme carrier protein 1(HCP 1 (show SLC46A1 Antibodies))is the long-sought intestinal heme transporter and was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Its mRNA was expressed in duodenum and regulated by hypoxia
Slc46a1/PCFT (show SLC46A1 Antibodies) plays critical role in intestinal folate absorption.
Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC (show SLC19A1 Antibodies) and PCFT (show SLC46A1 Antibodies).
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
, phosphodiesterase isozyme 7
, heme carrier protein 1
, proton-coupled folate transporter