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COA3 encodes a member of the cytochrome c oxidase assembly factor family. Additionally we are shipping Cytochrome C Oxidase Assembly Factor 3 Kits (12) and Cytochrome C Oxidase Assembly Factor 3 Proteins (3) and many more products for this protein.
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Data suggest that COX (show COX8A Antibodies) assembly factor 3 (hCOA3) is a disordered protein and that the flexibility of hCOA3 is crucial for its interaction with other proteins to favor mitochondrial protein (show COX6B2 Antibodies) translocation and assembly of proteins involved in the respiratory chain.
COX14 (show COX14 Antibodies) was undetectable in COA3 subject fibroblasts, and that COA3 was undetectable in fibroblasts from a COX14 (show COX14 Antibodies) subject, demonstrating the interdependence of these two COX (show COX8A Antibodies) assembly factors
Data show that mitochondrial protein (show COX6B2 Antibodies) ccdc56/MITRAC12/COA3 positively regulates mitochondrial fission by recruiting the fission factor Drp1 (show CRMP1 Antibodies).
hCOA3 stabilizes COX1 (show COX1 Antibodies) co-translationally and promotes its assembly with COX (show COX8A Antibodies) partner subunits.
Study comprehensively identified mammalian cytochrome c (show CYCS Antibodies) oxidase assembly factors. These analyses led to the discoveryof MITRAC12, which defines the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c (show CYCS Antibodies) oxidase)complexes.
Human ortholog of fungal COA3 (Cytochrome oxidase assembly)
This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function.
coiled-coil domain-containing protein 56
, cytochrome C oxidase assembly factor 3 homolog, mitochondrial
, cytochrome c oxidase assembly protein 3 homolog, mitochondrial
, coiled-coil domain containing 56
, mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa