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COX18 encodes a cytochrome c oxidase (COX)-assembly protein. Additionally we are shipping and many more products for this protein.
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COX20 stabilizes COX2 (show COX2 Antibodies) during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts with COX2 (show COX2 Antibodies) to promote translocation across the inner membrane of the COX2 (show COX2 Antibodies) C-tail that contains the apo (show C9orf3 Antibodies)-CuA site. The release of COX18 from this complex coincides with the binding of the SCO1 (show SCO1 Antibodies)-SCO2 (show SCO2 Antibodies)-COA6 copper metallation module to COX2 (show COX2 Antibodies)-COX20 to finalize COX2 (show COX2 Antibodies) biogenesis.
COX18 mutations may be very rare or associated with other phenotypes than isolated COX (show COX8A Antibodies) deficiency in infancy.
COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2\; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005
COX18 cytochrome c oxidase assembly homolog
, cytochrome c oxidase assembly homolog 18
, Cox18Hs1 protein
, Cox18Hs2 protein
, Cox18Hs3 protein
, cytochrome c oxidase assembly protein 18
, mitochondrial COX18
, mitochondrial inner membrane protein COX18