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anti-Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) (COX4I2) Antibodies

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. Additionally we are shipping Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COX4I2 84682 Q91W29
COX4I2 84701 Q96KJ9
COX4I2 84683 Q91Y94
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Top anti-Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from K562 cells, treated with insulin 0.01U/ml 15', using COX42 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of COS7 cells, using COX42 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to COX4I2 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml] Western Blot analysis of COX4I2 expression in transfected 293T cell line by COX4I2 monoclonal antibody (M01), clone 1F2.Lane 1: COX4I2 transfected lysate(20 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of COX4I2 expression in transfected 293T cell line by COX4I2 monoclonal antibody (M01), clone 1F2. Lane 1: COX4I2 transfected lysate(20 KDa). Lane 2: Non-transfected lysate. Immunoperoxidase of monoclonal antibody to COX4I2 on formalin-fixed paraffin-embedded human salivary gland (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$793.83
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Goat APC ELISA, WB   100 μL Log in to see 16 Days
$713.43
Details
Human Goat Alkaline Phosphatase (AP) ELISA, WB   100 μL Log in to see 16 Days
$713.43
Details

COX4I2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Human ,
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Rat (Rattus)


Top referenced anti-Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) Antibodies

  1. Human Monoclonal COX4I2 Primary Antibody for IHC (p), IP - ABIN566588 : Singh, Misiak, Beyer, Arnold: Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase. in Neurochemistry international 2010 (PubMed)
    Show all 5 references for ABIN566588

  2. Human Polyclonal COX4I2 Primary Antibody for IF, ELISA - ABIN1534368 : Hüttemann, Kadenbach, Grossman: Mammalian subunit IV isoforms of cytochrome c oxidase. in Gene 2001 (PubMed)
    Show all 2 references for ABIN1534368

More Antibodies against Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) Interaction Partners

Mouse (Murine) Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) (COX4I2) interaction partners

  1. Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 (show COX7A1 Antibodies) under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a (show HIF1A Antibodies)-independent.

  2. propose a model in which reduced tissue ATP levels explain protection from airway hyperresponsiveness, i.e., absence of COX4i2 leads to reduced lung COX (show CPOX Antibodies) activity and ATP levels, which results in impaired airway constriction

  3. the presence of the COX (show CPOX Antibodies) isoform IV-2 suppresses the sensitivity of COX (show CPOX Antibodies) to its allosteric regulator ATP and overrules the regulation of COX (show CPOX Antibodies) by the cellular energy level

  4. Cytochrome c oxidase subunit IV (show COX4I1 Antibodies) is essential for assembly and respiratory function of the enzyme complex.

  5. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 (show HIF1A Antibodies) reciprocally regulates COX4 (show COX4I1 Antibodies) subunit expression by activating transcription of the genes encoding COX4-2 and LON (show LONP1 Antibodies), a mitochondrial protease that is required for COX4-1 (show COX4I1 Antibodies) degradation.

Human Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) (COX4I2) interaction partners

  1. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ (show RBPJ Antibodies)), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5 (show CXXC5 Antibodies)).

  2. Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia.

  3. COX4I2 is regulated by a novel oxygen sensitive promoter element (5'-GGACGTTCCCACG-3') conserved in mammals. Gene activity is maximal at 4% oxygen. Lung cytochrome c oxidase (COX) is 2.5 fold more active compared to liver COX, which lacks COX4I2.

  4. COX4I2 is expressed in the highly oxygenated lung tissue. It is found in all cell types of the lung.

Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) (COX4I2) Antigen Profile

Protein Summary

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.

Gene names and symbols associated with COX4I2

  • cytochrome c oxidase subunit IV isoform 2 (Cox4i2) antibody
  • cytochrome c oxidase subunit IV isoform 2 (lung) (COX4I2) antibody
  • cytochrome c oxidase subunit IV isoform 2 (lung) (Cox4i2) antibody
  • COX4 antibody
  • COX4-2 antibody
  • COX4B antibody
  • COX4L2 antibody
  • COXIV-2 antibody
  • dJ857M17.2 antibody

Protein level used designations for COX4I2

Cox IV-2 , cytochrome c oxidase subunit 4 isoform 2, mitochondrial , cytochrome c oxidase, subunit IVb , COX IV-2 , cytochrome c oxidase subunit IV-like 2 , cytochrome c oxidase, subunit 4b

GENE ID SPECIES
84682 Mus musculus
84701 Homo sapiens
84683 Rattus norvegicus
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