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CYP2A6, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2A6 Kits (4) and CYP2A6 Proteins (3) and many more products for this protein.
Showing 10 out of 108 products:
Human Polyclonal CYP2A6 Primary Antibody for WB - ABIN2801900
Miles, Bickmore, Brook, McLaren, Meehan, Wolf: Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity. in Nucleic acids research 1989
Show all 4 Pubmed References
Human Polyclonal CYP2A6 Primary Antibody for WB - ABIN514822
Wang, Bian, Liu, Jin, Chen, Lin, Chen: Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes. in Pharmacogenomics 2011
Polymorphisms within the CYP2A6 gene are not a significant cause of high skatole levels.
findings suggest that CYP1A2 (show CYP1A2 Antibodies) alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6
Genetic polymorphisms in CYP2B6 (show CYP2B6 Antibodies) and CYP2A6 explained a significant proportion of variability in EFV plasma concentration in HIV-infected children in a multi-ethnic outpatient clinic.
In a Mexican Mestizo population, rs1137115(A) and rs4105144(T) in CYP2A6 are associated with cigarette consumption
CYP2B6 (show CYP2B6 Antibodies)/CYP2A6 genotypes were associated with increased reported suicidality among AIDS patients who had been randomly assigned to receive efavirenz-containing regimens in clinical trials. Strength of association varied by race/ethnicity.
The CYP2A6 gene product plays a major role in the nicotine metabolism pathway, which influences nicotine intake.
CYP2A6 activity provides information on lung cancer risk that is not captured by smoking history.
CYP2A6*4 genetic polymorphisms may not strongly affect smoking behavior but may possibly have an effect on nicotine dependence
CYP2A6 genetic variation alters striatal-cingulate circuits, network hubs, and executive processing in smokers. Because the CYP2A6 effect was seen only in smokers, these data suggest that the rate of nicotine metabolism-and thus the concentration of nicotine presented to the brain over the course of nicotine addiction-shapes brain circuits that, among other functions, compute reward and impulsivity processes.
a greater CYP2A6 activity causes smokers to smoke more extensively and be exposed to higher levels of carcinogens, resulting in an increased risk for lung cancer.
Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3\; however, it has been renamed CYP2A6.
, cytochrome p450 2A6
, 1,4-cineole 2-exo-monooxygenase
, cytochrome P450 2A6
, cytochrome P450 IIA3
, cytochrome P450(I)
, cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6
, flavoprotein-linked monooxygenase
, xenobiotic monooxygenase